Applicability of microdialysis as a technique for pharmacokinetic- pharmacodynamic (PK-PD) modeling of antihypertensive beta-blockers

Journal of Pharmacological and Toxicological Methods

Volumn 52, Issue 2, 2005, Pages 244-250

  Höcht, Christian ^a   DiVerniero, Carla ^a   Opezzo, Javier A W ^a   Taira, Carlos A ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

"Shunt" vascular probe; Aortic coarctation; Cardiovascular effects; Metoprolol; Microdialysis; Pharmacokinetic pharmacodynamic models

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; METOPROLOL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; AORTA COARCTATION; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR EFFECT; CHRONOTROPISM; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; FEMALE; HEART RATE; HYPERTENSION; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; NONHUMAN; RAT; SENSITIVITY ANALYSIS;

ADRENERGIC BETA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTIC COARCTATION; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; HEART RATE; HYPERTENSION; INJECTIONS, INTRAVENOUS; METOPROLOL; MICRODIALYSIS; RATS; RATS, WISTAR;

ANIMALIA;

EID: 23944482906     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.01.002     Document Type: Article

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