Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 16, 2006, Pages 4178-4183

  Lin, Hsiang Ru ^a   Abraham, Donald J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Androgen receptor (AR); Farnesoid x receptor (FXR); Nuclear receptors

Indexed keywords

ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; RAT; SYNDROME X;

ANTINEOPLASTIC AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHENODEOXYCHOLIC ACID; DNA-BINDING PROTEINS; DRUG DESIGN; GENES, REPORTER; HUMANS; METABOLIC SYNDROME X; MODELS, CHEMICAL; MODELS, MOLECULAR; NEOPLASMS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33745699183     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.084     Document Type: Article

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