Kennedy's disease: Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its clevage by caspase-3 and enhances cell death

Journal of Biological Chemistry

Volumn 278, Issue 37, 2003, Pages 34918-34924

  LaFevre Bernt, Michelle A ^b   Ellerby, Lisa M ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; NEUROLOGY; PROTEINS;

PHOSPHORYLATION;

BIOCHEMISTRY;

ANDROGEN RECEPTOR; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; POLYGLUTAMINE; PROTEIN P42; PROTEIN P44; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; EMBRYO; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; KENNEDY DISEASE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; X CHROMOSOME LINKAGE;

ALANINE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CASPASE 3; CASPASES; CELL DEATH; CELL LINE; DNA PRIMERS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCULAR ATROPHY, SPINAL; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECEPTORS, ANDROGEN; RECOMBINANT PROTEINS; SERINE; TRANSFECTION; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 0041816369     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302841200     Document Type: Article

References (44)

1. Fischbeck, K. H. (1997) J. Inherit. Metab. Dis. 20, 152-158
2. La Spada, A. R., Wilson, E. M., Lubahn, D. B., Harding, A. E., and Fischbeck, K. H. (1991) Nature 352, 77-79
3. Brown, T. R., Lubahn, D. B., Wilson, E. M., Joseph, D. R., French, F. S., and Migeon, C. J. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 8151-8155
4. Yong, E. L., Ng, S. C., Roy, A. C., Yun, G., and Ratnam, S. S. (1994) Lancet 344, 826-827
5. Pinsky, L., Trifiro, M., Kaufman, M., Beitel, L. K., Mhatre, A., Kazemi-Esfarjani, P., Sabbaghian, N., Lumbroso, R., Alvarado, C., Vasiliou, M., and Gottlieb, B. (1992) Clin. Invest. Med. 15, 456-472
6. Ross, C. A. (1995) Neuron 15, 493-496
7. Beato, M., Herrlich, P., and Schutz, G. (1995) Cell 83, 851-857
8. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
9. Ellerby, L. M., Hackam, A. S., Propp, S. S., Ellerby, H. M., Rabizadeh, S., Cashman, N. R., Trifiro, M. A., Pinsky, L., Wellington, C. L., Salvesen, G. S., Hayden, M. R., and Bredesen, D. E. (1999) J. Neurochem. 72, 185-195
10. Wellington, C. L., Ellerby, L. M., Hackam, A. S., Margolis, R. L., Trifiro, M. A., Singaraja, R., McCutcheon, K., Salvesen, G. S., Propp, S. S., Bromm, M., Rowland, K. J., Zhang, T., Rasper, D., Roy, S., Thornberry, N., Pinsky, L., Kakizuka, A., Ross, C. A., Nicholsen, D. W., Bredesen, D. E., and Hayden, M. R. (1998) J. Biol. Chem. 273, 9158-9167
11. Goldberg, Y. P., Nicholson, D. W., Rasper, D. M., Kalchman, M. A., Koide, H. B., Graham, R. K., Bromm, M., Kazemi-Esfarjani, P., Thornberry, N. A., Vaillancourt, J. P., and Hayden, M. R. (1996) Nat. Genet. 13, 442-449
12. Miyashita, T., Okamura-Oho, Y., Mito, Y., Nagafuchi, S., and Yamada, M. (1997) J. Biol. Chem. 272, 29238-29242
13. Ellerby, L. M., Andrusiak, R. L., Wellington, C. L., Hackam, A. S., Propp, S. S., Wood, J. D., Sharp, A. H., Margolis, R. L., Ross, C. A., Salvesen, G. S., Hayden, M. R., and Bredesen, D. E., (1999) J. Biol. Chem. 274, 8730-8736
14. Abel, A., Walcott, J., Woods, J., Duda, J., and Merry, D. E. (2001) Hum. Mol. Genet. 10, 107-116
15. Katsuno, M., Adachi, H., Kume, A., Li, M., Nakagomi, Y., Niwa, H., Sang, C., Kobayashi, Y., Doyu, M., and Sobue, G. (2002) Neuron 35, 843-854
16. Takeyama, K., Ito, S., Yamamoto, A., Tanimoto, H., Furutani, T., Kanuka, H., Miura, M., Tabata, T., and Kato, S. (2002) Neuron 35, 855-864
17. DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., and Aronin, N. (1997) Science 277, 1990-1993
18. Wellington, C. L., Ellerby, L. M., Gutekunst, C. A., Rogers, D., Warby, S., Graham, R. K., Loubser, O., van Raamsdonk, J., Singaraja, R., Yang, Y. Z., Gafni, J., Bredesen, D., Hersch, S. M., Leavitt, B. R., Roy, S., Nicholson, D. W., and Hayden, M. R. (2002) J. Neurosci. 22, 7862-7872
19. Brinkmann, A. O., and Trapman, J. (2000) Adv. Pharmacol. 47, 317-341
20. Lin, H. K., Yeh, S., Kang, H. Y., and Chang, C. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 7200-7205
21. Yeh, S., Lin, H. K., Kang, H. Y., Thin, T. H., Lin, M. F., and Chang, C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 5458-5463
22. Kyriakis, J. M. (2000) Science's STKE http://STKE. sciencemag.org/cgi/content/full/sigtrans;2000/48/pe1
23. Migliaccio, A., Castoria, G., Di Domenico, M., de Falco, A., Bilancio, A., Lombardi, M., Barone, M. V., Ametrano, D., Zannini, M. S., Abbondanza, C., and Auricchio, F. (2000) EMBO J. 19, 5406-5417
24. Ueda, T., Bruchovsky, N., and Sadar, M. D. (2002) J. Biol. Chem. 277, 7076-7085
25. Koh, J. Y., and Choi, D. W. (1987) J. Neurosci. Methods 20, 83-90
26. Lewis, J. M., Baskaran, R., Taagepera, S., Schwartz, M. A., and Wang, J. Y. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 15174-15179
27. Gioeli, D., Ficarro, S. B., Kwiek, J. J., Aaronson, D., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., Hunt, D. F., and Weber, M. J. (2002) J. Biol. Chem. 277, 29304-29314
28. Sampt, E. R., Fernandez, G. A., Lehman, J. A., Corey, S. J., Huang, C. K., and Gomez-Cambronero, J. (2001) J. Biochem. Biophys. Methods 48, 219-237
29. Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., and Orr, H. T. (1998) Cell 95, 41-53
30. Peters, M. F., Nucifora, F. C., Jr., Kushi, J., Seaman, H. C., Cooper, J. K., Herring, W. J., Dawson, V. L., Dawson, T. M., and Ross, C. A. (1999) Mol. Cell Neurosci. 14, 121-128
31. Nucifora, F. C., Jr., Ellerby, L. M., Wellington, C. L., Wood, J. D., Herring, W. J., Sawa, A., Hayden, M. R., Dawson, V. L., Dawson, T. M., and Ross, C. A. (2002) J. Biol. Chem. 2, 2
32. Welch, W. J., and Diamond, M. I. (2001) Hum. Mol. Genet. 10, 3063-3074
33. Ross, C. A. (2002) Neuron 35, 819
34. Cooper, J. A., and King, C. S. (1986) Mol. Cell Biol. 6, 4467-4477
35. Martindale, J. L., and Holbrook, N. J. (2002) J. Cell Physiol. 192, 1-15
36. Suh, Y. (2002) Mech. Ageing Dev. 123, 881-890
37. Vaudry, D., Stork, P. J., Lazarovici, P., and Eiden, L. E. (2002) Science 296, 1648-1649
38. Murray, B., Alessandrini, A., Cole, A. J., Yee, A. G., and Furshpan, E. J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11975-11980
39. Chen, H. K., Fernandez-Funez, P., Acevedo, S. F., Lam, Y. C., Kaytor, M. D., Fernandez, M. H., Aitken, A., Skoulakis, E. M., Orr, H. T., Botas, J., and Zoghbi, H. Y. (2003) Cell 113, 457-468
40. Emamian, E. S., Kaytor, M. D., Duvick, L. A., Zu, T., Tousey, S. K., Zoghbi, H. Y., Clark, H. B., and Orr, H. T. (2003) Neuron 38, 375-387
41. Humbert, S., Bryson, E. A., Cordelieres, F. P., Connors, N. C., Datta, S. R., Finkbeiner, S., Greenberg, M. E., and Saudou, F. (2002) Dev. Cell 2, 831-837
42. Kim, T. W., Pettingell, W. H., Jung, Y. K., Kovacs, D. M., and Tanzi, R. E. (1997) Science 277, 373-376
43. Lu, P. J., Wulf, G., Zhou, X. Z., Davies, P., and Lu, K. P. (1999) Nature 399, 784-788
44. Wittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., and Feany, M. B. (2001) Science 293, 711-714