Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity

Molecular Pharmacology

Volumn 54, Issue 3, 1998, Pages 459-462

  Shen, Maoxlng ^a   Thayer, Stanley A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 PHOSPHONOMETHYLPIPECOLIC ACID; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; GLUTAMIC ACID; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY; SYNAPTIC TRANSMISSION;

EID: 0031706164     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.459     Document Type: Article

References (30)

1. Abele A and Miller R (1990) Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons. Neurosci Lett 115:195-200.
2. Abele AE, Scholz KP, Scholz WK, and Miller RJ (1990) Excitotoxicity induced by enhanced excitatory neurotransmission in cultured hippocampal pyramidal neurons. Neuron 4:413-419.
3. Abood ME and Martin BR (1996) Molecular neurobiology of the cannabinoid receptor. Int Rev Neurobiol 39:197-221.
4. Adams IB and Martin BR (1996) Cannabis: pharmacology and toxicology in animals and humans. Addiction 91:1585-1614.
5. Annas GJ (1997) Reefer madness: the federal response to California's medical-marijuana law. N Engl J Med 337:435-439.
6. Beal MF, Hyman BT, and Koroshetz W (1993) Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 16:125-131.
7. Childers SR, Pacheco MA, Bennett BA, Edwards TA, Hampson RE, Mu J, and Deadwyler SA (1993) Cannabinoid receptors: G-protein-mediated signal transduction mechanisms. Biochem Soc Symp 59:27-50.
8. Choi DW (1994) Glutamate receptors and the induction of excitotoxic neuronal death. Prog Brain Res 100:47-51.
9. Deadwyler SA, Hampson RE, Bennett BA, Edwards TA, Mu J, Pacheco MA, Ward SJ, and Childers SR (1993) Cannabinoids modulate potassium current in cultured hippocampal neurons. Recept Channels 1:121-134.
10. Henry DJ and Chavkin C (1995) Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes. Neurosci Lett 186:91-94.
11. Herkenham M, Lynn AB, Little MD, Johnson MR, Melvin LS, de Costa BR, and Rice KC (1990) Cannabinoid receptor localization in brain. Proc Natl Acad Sci USA 87:1932-1936.
12. Howlett A (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634.
13. 2+ concentrations in rat hippocampal slices. Epilepsy Res 4:187-200.
14. Mackie K and Hille B (1992) Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci USA 89:3825-3829.
15. Mackie K, Lai Y, Westenbroek R, and Mitchell R (1995) Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J Neurosci 15:6552-6561.
16. Meldrum BS (1993) Excitotoxicity and selective neuronal loss in epilepsy. Brain Pathol 3:405-412.
17. Nadler V, Mechoulam R, and Sokolovsky M (1993) The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates N-methyl-D-aspartate receptor-mediated neurotoxicity in primary cultures of rat forebrain. Neurosci Lett 162:43-45.
18. Olney JW (1989) Excitatory amino acids and neuropsychiatric disorders. Biol Psychiatry 26:505-525.
19. Peterson C, Neal JH, and Cotman CW (1989) Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons. Dev Brain Res 48:187-195.
20. Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, and Wadleigh RG (1991) Recent clinical experience with dronabinol. Pharmacol Biochem Behav 40:695-700.
21. Rose K, Christine C, and Choi D (1990) Magnesium removal induces paroxysmal neuronal firing and NMDA receptor-mediated neuronal degeneration in cortical cultures. Neurosci Lett 115:313-317.
22. Rothman S and Olney J (1995) Excitotoxicity and the NMDA receptor: still lethal after eight years. Trends Neurosci 18:57-58.
23. Shen M, Piser TM, Seybold VS, and Thayer SA (1996) Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission in rat hippocampal cultures. J Neurosci 16:4322-4334.
24. 9-Tetrahydrocannabinol acts as a partial agonist to inhibit glutamatergic synaptic transmission between cultured rat hippocampal neurons. Soc Neurosci Abstr 23:2312.
25. Shen M and Thayer SA (1998) The cannabinoid agonist Win55212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neurons. Brain Res 783:77-84.
26. Skaper SD, Buriani A, Dal Toso R, Petrelli L, Romanello S, Facci L, and Leon A (1996) The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci USA 93:3984-3989.
27. Thompson SM, Haas HL, and Gahwiler BH (1992) Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro. J Physiol (Lond) 451:347-363.
28. Twitchell W, Brown S, and Mackie K (1997) Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 78:43-50.
29. Yamada K, Teraoka T, Morita S, Hasegawa T, and Nabeshima T (1994) ω-Conotoxin GVIA protects against ischemia-induced neuronal death in the mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat. Neuropharmacology 33:251-254.
30. Yoshida H, Usami N, Ohishi Y, Watanabe K, Yamamoto I, and Yoshimura H (1995) Synthesis and pharmacological effects in mice of halogenated cannabinol derivatives. Chem Pharm Bull (Tokyo) 43:335-337.