Alopecia areata: Pathogenesis and potential for therapy

Expert Reviews in Molecular Medicine

Volumn 8, Issue 14, 2006, Pages 1-19

  Lu, Wei ^a   Shapiro, Jerry ^a   Yu, Mei ^a   Barekatain, Armin ^a   Lo, Blanche ^a   Finner, Andreas ^a   McElwee, Kevin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ALEFACEPT; AMMONIUM TRICHLORO(DIOXYETHYLENE O,O')TELLURATE; B7 ANTIGEN; CORTICOSTEROID; CYCLOSPORIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EFALIZUMAB; ETANERCEPT; FONTOLIZUMAB; GLATIRAMER; INFLIXIMAB; LIPOSOME; MONOCLONAL ANTIBODY; TACROLIMUS; THALIDOMIDE; UNCLASSIFIED DRUG;

ALOPECIA AREATA; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG PENETRATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HAIR LOSS; HUMAN; INFLAMMATORY CELL; MEDICAL RESEARCH; MUTAGENICITY; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; STEM CELL TRANSPLANTATION; UNSPECIFIED SIDE EFFECT;

ALOPECIA AREATA; ANIMALS; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; LYMPHOCYTE ACTIVATION; MALE; MICE; PHENOTYPE;

EID: 33745286249     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S146239940601101X     Document Type: Review

References (165)

1. Chase, H.B. (1954) Growth of the hair. Physiol Rev 34, 113-126, PubMed: 13120379
2. Oliver, R.F. (1967) The experimental induction of whisker growth in the hooded rat by implantation of dermal papillae. J Embryol Exp Morphol 18, 43-51, PubMed: 6048979
3. McElwee, K.J. et al. (2003) Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol 121, 1267-1275, PubMed: 14675169
4. Stenn, K.S. and Paus, R. (2001) Controls of hair follicle cycling. Physiol Rev 81, 449-494
5. Hamilton, J.B. (1951) Patterned loss of hair in man; types and incidence. Ann N Y Acad Sci 53, 708-728, PubMed: 14819896
6. Birch, M.P., Lalla, S.C. and Messenger, A.G. (2002) Female pattern hair loss. Clin Exp Dermatol 27, 383-388, PubMed: 12190638
7. Gan, D.C. and Sinclair, R.D. (2005) Prevalence of male and female pattern hair loss in Maryborough. J Investig Dermatol Symp Proc 10, 184-189, PubMed: 16382660
8. de Boer-Dennert, M. et al. (1997) Patient perceptions of the side-effects of chemotherapy: The influence of 5HT3 antagonists. Br J Cancer 76, 1055-1061, PubMed: 9376266
9. Carelle, N. et al. (2002) Changing patient perceptions of the side effects of cancer chemotherapy. Cancer 95, 155-163, PubMed: 12115329
10. Batchelor, D. (2001) Hair and cancer chemotherapy: Consequences and nursing care - a literature study. Eur J Cancer Care (Engl) 10, 147-163, PubMed: 11829374
11. Hesketh, P.J. et al. (2004) Chemotherapy-induced alopecia: Psychosocial impact and therapeutic approaches. Support Care Cancer 12, 543-549, PubMed: 15221580
12. Tierney, A.J. (1987) Preventing chemotherapy-induced alopecia in cancer patients: Is scalp cooling worthwhile? J Adv Nurs 12, 303-310, PubMed: 3648073
13. Williamson, D., Gonzalez, M. and Finlay, A.Y. (2001) The effect of hair loss on quality of life. J Eur Acad Dermatol Venereol 15, 137-139, PubMed: 11495520
14. Cash, T.F. (1999) The psychosocial consequences of androgenetic alopecia: A review of the research literature. Br J Dermatol 141, 398-405, PubMed: 10583042
15. Schmidt, S. et al. (2001) Strategies of coping and quality of life in women with alopecia. Br J Dermatol 144, 1038-1043, PubMed: 11359394
16. Shapiro, J. et al. (1997) Systemic cyclosporine and low-dose prednisone in the treatment of chronic severe alopecia areata: A clinical and immunopathologic evaluation. J Am Acad Dermatol 36, 114-117, PubMed: 8996277
17. Dawber, D. et al. (1998) Disorders of hair: Alopecia areata. In Rook/ Wilkinson/Ebling Textbook of Dermatology (Champion, R.H. et al., eds), pp. 2919-2927, Blackwell Science
18. Ellis, J.A., Sinclair, R. and Harrap, S.B. (2002) Androgenetic alopecia: pathogenesis and potential for therapy. Expert Rev. Mol. Med 19 November, http://www.expertreviews.org/02005112h.htm
19. Safavi, K.H. et al. (1995) Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc 70, 628-633, PubMed: 7791384
20. Muller, S.A. and Winkelmann, R.K. (1963) Alopecia Areata. An Evaluation of 736 Patients. Arch Dermatol 88, 290-297, PubMed: 14043621
21. Paus, R., Slominski, A. and Czarnetzki, B.M. (1993) Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J Biol Med 66, 541-554, PubMed: 7716973
22. McDonagh, A.J. and Messenger, A.G. (1996) The pathogenesis of alopecia areata. Dermatol Clin 14, 661-670, PubMed: 9238324
23. McElwee, K. et al. (2001) Genetic susceptibility and severity of alopecia areata in human and animal models. Eur J Dermatol 11, 11-16, PubMed: 11174130
24. Wang, S.J. et al. (1994) Increased risk for type I (insulin-dependent) diabetes in relatives of patients with alopecia areata (AA). Am J Med Genet 51, 234-239, PubMed: 8074151
25. Kurtev, A. and Iliev, E. (2005) Thyroid autoimmunity in children and adolescents with alopecia areata. Int J Dermatol 44, 457-461, PubMed: 15941431
26. Cunliffe, W.J. et al. (1969) Alopecia areata, thyroid disease and autoimmunity. Br J Dermatol 81, 877-881, PubMed: 5359449
27. Milgraum, S.S. et al. (1987) Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger. J Am Acad Dermatol 17, 57-61, PubMed: 3301924
28. Shellow, W.V., Edwards, J.E. and Koo, J.Y. (1992) Profile of alopecia areata: A questionnaire analysis of patient and family. Int J Dermatol 31, 186-189, PubMed: 1568816
29. Puavilai, S. et al. (1994) Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol 33, 632-633, PubMed: 8002158
30. Main, R.A. et al. (1975) Smooth muscle antibodies and alopecia areata. Br J Dermatol 92, 389-393, PubMed: 1156552
31. McElwee, K.J. et al. (1998) Comparison of alopecia areata in human and nonhuman mammalian species. Pathobiology 66, 90-107, PubMed: 9645633
32. Perret, C., Wiesner-Menzel, L. and Happle, R. (1984) Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata. Acta Derm Venereol 64, 26-30, PubMed: 6203277
33. Ranki, A. et al. (1984) Immunohistochemical and electron microscopic characterization of the cellular infiltrate in alopecia (areata, totalis, and universalis). J Invest Dermatol 83, 7-11, PubMed: 6376642
34. Zhang, J.G. and Oliver, R.F. (1994) Immunohistological study of the development of the cellular infiltrate in the pelage follicles of the DEBR model for alopecia areata. Br J Dermatol 130, 405-414, PubMed: 7910477
35. Sundberg, J.P., Cordy, W.R. and King, L.E., Jr. (1994) Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102, 847-856, PubMed: 8006447
36. Wiesner-Menzel, L. and Happle, R. (1984) Intrabulbar and peribulbar accumulation of dendritic OKT 6-positive cells in alopecia areata. Arch Dermatol Res 276, 333-334, PubMed: 6548356
37. McDonagh, A.J. et al. (1993) HLA and ICAM-1 expression in alopecia areata in vivo and in vitro: The role of cytokines. Br J Dermatol 129, 250-256, PubMed: 7506926
38. Nickoloff, B.J. and Griffiths, C.E. (1991) Aberrant intercellular adhesion molecule-1 (ICAM-1) expression by hair-follicle epithelial cells and endothelial leukocyte adhesion molecule-1 (ELAM-1) by vascular cells are important adhesion-molecule alterations in alopecia areata. J Invest Dermatol 96, 91S-92S, PubMed: 1708803
39. Brocker, E.B. et al. (1987) Abnormal expression of class I and class II major histocompatibility antigens in alopecia areata: Modulation by topical immunotherapy. J Invest Dermatol 88, 564-568, PubMed: 3471816
40. Hoffmann, R. et al. (1994) Cytokine mRNA levels in Alopecia areata before and after treatment with the contact allergen diphenylcyclopropenone. J Invest Dermatol 103, 530-533, PubMed: 7930677
41. Tobin, D.J. et al. (1994) Antibodies to hair follicles in alopecia areata. J Invest Dermatol 102, 721-724, PubMed: 8176253
42. Tobin, D.J., Orentreich, N. and Bystryn, J.C. (1994) Autoantibodies to hair follicles in normal individuals. Arch Dermatol 130, 395-396, PubMed: 8129427
43. Tobin, D.J. (2003) Characterization of hair follicle antigens targeted by the anti-hair follicle immune response. J Investig Dermatol Symp Proc 8, 176-181, PubMed: 14582669
44. Bystryn, J.C., Orentreich, N. and Stengel, F. (1979) Direct immunofluorescence studies in alopecia areata and male pattern alopecia. J Invest Dermatol 73, 317-320, PubMed: 387883
45. Hoffmann, R. and Happle, R. (1999) [Alopecia areata. Part 2: Therapy]. Hautarzt 50, W310-315, PubMed: 10354929
46. Madani, S. and Shapiro, J. (2000) Alopecia areata update. J Am Acad Dermatol 42, 549-566; quiz 567-570, PubMed: 10727299
47. Freyschmidt-Paul, P. et al. (2001) Current and potential agents for the treatment of alopecia areata. Curr Pharm Des 7, 213-230, PubMed: 11311114
48. McElwee, K.J. et al. (1999) Alopecia areata: An autoimmune disease? Exp Dermatol 8, 371-379, PubMed: 10536963
49. McElwee, K.J. and Hoffmann, R. (2002) Alopecia areata - animal models. Clin Exp Dermatol 27, 410-417, PubMed: 12190642
50. Colombe, B.W. et al. (1995) HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol 33, 757-764, PubMed: 7593774
51. van der Steen, P. et al. (1992) The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol 72, 373-375, PubMed: 1361288
52. Alsaleh, Q.A. et al. (1995) Concurrent appearance of alopecia areata in siblings. Pediatr Dermatol 12, 285-286, PubMed: 7501568
53. Scerri, L. and Pace, J.L. (1992) Identical twins with identical alopecia areata. J Am Acad Dermatol 27, 766-767, PubMed: 1430401
54. Cole, G.W. and Herzlinger, D. (1984) Alopecia universalis in identical twins. Int J Dermatol 23, 283, PubMed: 6539757
55. Jackow, C. et al. (1998) Alopecia areata and cytomegalovirus infection in twins: Genes versus environment? J Am Acad Dermatol 38, 418-425, PubMed: 9520023
56. Sharma, V.K., Dawn, G. and Kumar, B. (1996) Profile of alopecia areata in Northern India. Int J Dermatol 35, 22-27, PubMed: 8838924
57. Gol'dshtein, L.M. and Chipizhenko, V.A. (1978) [Familial alopecia areata]. Vestn Dermatol Venerol 36-38, PubMed: 706730
58. Hordinsky, M.K. et al. (1984) Familial alopecia areata. HLA antigens and autoantibody formation in an American family. Arch Dermatol 120, 464-468, PubMed: 6231002
59. Valsecchi, R. et al. (1985) Familial alopecia areata - genetic susceptibility or coincidence? Acta Derm Venereol 65, 175-177, PubMed: 2408426
60. Du Vivier, A. and Munro, D.D. (1975) Alopecia areata, autoimmunity, and Down's syndrome. Br Med J 1, 191-192, PubMed: 122906
61. Carter, D.M. and Jegasothy, B.V. (1976) Alopecia areata and Down syndrome. Arch Dermatol 112, 1397-1399, PubMed: 134671
62. Betterle, C., Greggio, N.A. and Volpato, M. (1998) Clinical review 93: Autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab 83, 1049-1055, PubMed: 9543115
63. Kianto, U. et al. (1977) HLA-B12 in alopecia areata. Arch Dermatol 113, 1716, PubMed: 596904
64. Hacham-Zadeh, S. et al. (1981) HLA and alopecia areata in Jerusalem. Tissue Antigens 18, 71-74, PubMed: 7330849
65. Averbakh, E.V. and Pospelov, L.E. (1986) [HLA antigens of patients with alopecia areata]. Vestn Dermatol Venerol 24-26, PubMed: 3457498
66. Xiao, F.L. et al. (2005) Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans. Arch Dermatol Res 297, 201-209, PubMed: 16231148
67. Barahmani, N. et al. (2006) Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata. J Invest Dermatol 126, 74-78, PubMed: 16417220
68. Duvic, M. et al. (1991) HLA-D locus associations in alopecia areata. DRw52a may confer disease resistance. Arch Dermatol 127, 64-68, PubMed: 1670917
69. Friedman, P.S. (1985) Clinical and immunologic association of alopecia areata. Semin Dermatol 4, 9-15
70. Orecchia, G. et al. (1987) Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata. Dermatologica 175, 10-14, PubMed: 3497062
71. de Andrade, M. et al. (1999) Alopecia areata in families: Association with the HLA locus. J Investig Dermatol Symp Proc 4, 220-223, PubMed: 10674370
72. Welsh, E.A. et al. (1994) Human leukocyte antigen-DQB1*03 alleles are associated with alopecia areata. J Invest Dermatol 103, 758-763, PubMed: 7798612
73. Colombe, B.W., Lou, C.D. and Price, V.H. (1999) The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Investig Dermatol Symp Proc 4, 216-219, PubMed: 10674369
74. Duvic, M. et al. (1995) Analysis of HLA-D locus alleles in alopecia areata patients and families. J Invest Dermatol 104, 5S-6S, PubMed: 7738397
75. Morling, N. et al. (1991) DNA polymorphism of HLA class II genes in alopecia areata. Dis Markers 9, 35-42, PubMed: 1683825
76. Akar, A. et al. (2002) HLA class II alleles in patients with alopecia areata. Eur J Dermatol 12, 236-239, PubMed: 11978563
77. Broniarczyk-Dyla, G. et al. (2002) The protective role of the HLA-DR locus in patients with various clinical types of alopecia areata. Arch Immunol Ther Exp (Warsz) 50, 333-336, PubMed: 12455867
78. Wucherpfennig, K.W. (2001) Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Curr Opin Immunol 13, 650-656, PubMed: 11677085
79. Messenger, A.G. and Bleehen, S.S. (1985) Expression of HLA-DR by anagen hair follicles in alopecia areata. J Invest Dermatol 85, 569-572, PubMed: 2415641
80. Tarlow, J.K. et al. (1994) Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J Invest Dermatol 103, 387-390, PubMed: 8077705
81. Tazi-Ahnini, R. et al. (2002) Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: Strong severity association and possible gene interaction. Eur J Immunogenet 29, 25-30, PubMed: 11841485
82. Galbraith, G.M. et al. (1999) Contribution of interleukin 1beta and KM loci to alopecia areata. Hum Hered 49, 85-89, PubMed: 10077728
83. Barahmani, N. et al. (2002) Interleukin-1 receptor antagonist allele 2 and familial alopecia areata. J Invest Dermatol 118, 335-337, PubMed: 11841553
84. Galbraith, G.M., Thiers, B.H. and Pandey, J.P. (1984) Gm allotype associated resistance and susceptibility to alopecia areata. Clin Exp Immunol 56, 149-152, PubMed: 6424985
85. Galbraith, G.M. and Pandey, J.P. (1989) Km1 allotype association with one subgroup of alopecia areata. Am J Hum Genet 44, 426-428, PubMed: 2916584
86. Galbraith, G.M. and Pandey, J.P. (1995) Tumor necrosis factor alpha (TNF-alpha) gene polymorphism in alopecia areata. Hum Genet 96, 433-436, PubMed: 7557966
87. Cork, M.J., Crane, A.M. and Duff, G.W. (1996) Genetic control of cytokines. Cytokine gene polymorphisms in alopecia areata. Dermatol Clin 14, 671-678, PubMed: 9238325
88. Tazi-Ahnini, R. et al. (2002) Role of the autoimmune regulator (AIRE) gene in alopecia areata: Strong association of a potentially functional AIRE polymorphism with alopecia universalis. Tissue Antigens 60, 489-495, PubMed: 12542742
89. Tazi-Ahnini, R. et al. (2003) Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. Hum Genet 112, 400-403, PubMed: 12589427
90. Tazi-Ahnini, R. et al. (2000) Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): Evidence of association with alopecia areata in the Down syndrome region. Hum Genet 106, 639-645, PubMed: 10942113
91. Martinez-Mir, A. et al. (2003) Genetic linkage studies in alopecia areata. J Investig Dermatol Symp Proc 8, 199-203, PubMed: 14582673
92. Duvic, M. et al. (2003) Alopecia areata registry: An overview. J Investig Dermatol Symp Proc 8, 219-221, PubMed: 14582678
93. Elenkov, I.J. and Chrousos, G.P. (2002) Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci 966, 290-303, PubMed: 12114286
94. Mehlman, R.D. and Griesemer, R.D. (1968) Alopecia areata in the very young. Am J Psychiatry 125, 605-614, PubMed: 5683446
95. Colon, E.A. et al. (1991) Lifetime prevalence of psychiatric disorders in patients with alopecia areata. Compr Psychiatry 32, 245-251, PubMed: 1884604
96. Liakopoulou, M. et al. (1997) Children with alopecia areata: Psychiatric symptomatology and life events. J Am Acad Child Adolesc Psychiatry 36, 678-684, PubMed: 9136503
97. Kavak, A., Yesildal, N. and Parlak, A.H. (2002) Effect of two consecutive earthquakes on outbreaks of alopecia areata. J Dermatol 29, 414-418, PubMed: 12184638
98. Ikeda, T. (1965) A new classification of alopecia areata. Dermatologica 131, 421-445, PubMed: 5864736
99. Penders, A.J. (1968) Alopecia areata and atopy. Dermatologica 136, 395-399, PubMed: 5662284
100. De Waard-van der Spek, F.B. et al. (1989) Juvenile versus maturity-onset alopecia areata - a comparative retrospective clinical study. Clin Exp Dermatol 14, 429-433, PubMed: 2605805
101. Weise, K. et al. (1996) Topical immunotherapy in alopecia areata: anamnestic and clinical criteria of prognostic significance. Dermatology 192, 129-133, PubMed: 8829494
102. Bigazzi, P.E. (1994) Autoimmunity and heavy metals. Lupus 3, 449-453, PubMed: 7704000
103. Elkayam, O., Yaron, M. and Caspi, D. (1999) Minocycline-induced autoimmune syndromes: An overview. Semin Arthritis Rheum 28, 392-397, PubMed: 10406406
104. Kissler, S., Anderton, S.M. and Wraith, D.C. (2001) Antigen-presenting cell activation: A link between infection and autoimmunity? J Autoimmun 16, 303-308, PubMed: 11334496
105. Holsapple, M.P. (2002) Autoimmunity by pesticides: A critical review of the state of the science. Toxicol Lett 127, 101-109, PubMed: 12052647
106. McElwee, K.J. et al. (2003) Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice. Exp Dermatol 12, 30-36, PubMed: 12631244
107. McElwee, K.J. et al. (1999) Spontaneous alopecia areata-like hair loss in one congenic and seven inbred laboratory mouse strains. J Investig Dermatol Symp Proc 4, 202-206, PubMed: 10674366
108. Smyth, J.R., Jr. and McNeil, M. (1999) Alopecia areata and universalis in the Smyth chicken model for spontaneous autoimmune vitiligo. J Investig Dermatol Symp Proc 4, 211-215, PubMed: 10674368
109. McElwee, K.J. (2003) Spontaneous rat model of alopecia areata in the Dundee Experimental Bald Rat (DEBR). In Animal Models of Human Inflammatory Skin Diseases (Chan, L.S., eds), pp. 451-468, CRC Press
110. Michie, H.J. et al. (1990) Immunobiological studies on the alopecic (DEBR) rat. Br J Dermatol 123, 557-567, PubMed: 2147388
111. Michie, H.J. et al. (1991) The DEBR rat: An animal model of human alopecia areata. Br J Dermatol 125, 94-100, PubMed: 1911310
112. McElwee, K.J., Spiers, E.M. and Oliver, R.F. (1996) In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata. Br J Dermatol 135, 211-217, PubMed: 8881662
113. McElwee, K.J. et al. (2005) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 124, 947-957, PubMed: 15854035
114. Tobin, D.J. et al. (1997) Autoantibodies to hair follicles in C3H/HeJ mice with alopecia areata-like hair loss. J Invest Dermatol 109, 329-333, PubMed: 9284100
115. McElwee, K.J., Pickett, P. and Oliver, R.F. (1996) The DEBR rat, alopecia areata and autoantibodies to the hair follicle. Br J Dermatol 134, 55-63, PubMed: 8745887
116. McElwee, K.J. et al. (1998) Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111, 797-803, PubMed: 9804341
117. Carroll, J.M. et al. (2002) Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 119, 392-402, PubMed: 12190862
118. McElwee, K.J., Spiers, E.M. and Oliver, R.F. (1999) Partial restoration of hair growth in the DEBR model for Alopecia areata after in vivo depletion of CD4+ T cells. Br J Dermatol 140, 432-437, PubMed: 10233262
119. Gilhar, A. et al. (1998) Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101, 62-67, PubMed: 9421466
120. Gilhar, A. et al. (2002) Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: Transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 138, 916-922, PubMed: 12071819
121. Westgate, G.E., Craggs, R.I. and Gibson, W.T. (1991) Immune privilege in hair growth. J Invest Dermatol 97, 417-420, PubMed: 1714928
122. Paus, R., Christoph, T. and Muller-Rover, S. (1999) Immunology of the hair follicle: A short journey into terra incognita. J Investig Dermatol Symp Proc 4, 226-234, PubMed: 10674372
123. Paus, R. (1996) Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 3, 248-258
124. Parakkal, P.F. (1969) Role of macrophages in collagen resorption during hair growth cycle. J Ultrastruct Res 29, 210-217, PubMed: 5362393
125. Eichmuller, S. et al. (1998) Clusters of perifollicular macrophages in normal murine skin: Physiological degeneration of selected hair follicles by programmed organ deletion. J Histochem Cytochem 46, 361-370, PubMed: 9487118
126. Weedon, D. and Strutton, G. (1981) Apoptosis as the mechanism of the involution of hair follicles in catagen transformation. Acta Derm Venereol 61, 335-339, PubMed: 6173989
127. Lindner, G. et al. (1997) Analysis of apoptosis during hair follicle regression (catagen). Am J Pathol 151, 1601-1617, PubMed: 9403711
128. McElwee, K.J. et al. (2003) Alopecia areata susceptibility in rodent models. J Investig Dermatol Symp Proc 8, 182-187, PubMed: 14582670
129. McElwee, K.J. et al. (1997) Topical FK506: A potent immunotherapy for alopecia areata? Studies using the Dundee experimental bald rat model. Br J Dermatol 137, 491-497, PubMed: 9390322
130. Freyschmidt-Paul, P. et al. (2001) Treatment of alopecia areata in C3H/ HeJ mice with the topical immunosuppressant FK506 (Tacrolimus). Eur J Dermatol 11, 405-409, PubMed: 11525945
131. Price, V.H., Willey, A. and Chen, B.K. (2005) Topical tacrolimus in alopecia areata. J Am Acad Dermatol 52, 138-139, PubMed: 15627095
132. Oliver, R.F. and Lowe, J.G. (1995) Oral cyclosporin A restores hair growth in the DEBR rat model for alopecia areata. Clin Exp Dermatol 20, 127-131, PubMed: 8565246
133. Verma, D.D. et al. (2004) Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles. Eur J Dermatol 14, 332-338, PubMed: 15358573
134. Ferrando, J. and Grimalt, R. (1999) Partial response of severe alopecia areata to cyclosporine A. Dermatology 199, 67-69, PubMed: 10449964
135. Phillips, M.A., Graves, J.E. and Nunley, J.R. (2005) Alopecia areata presenting in 2 kidney-pancreas transplant recipients taking cyclosporine. J Am Acad Dermatol 53, S252-255, PubMed: 16227102
136. Oliveira, V.D., Zankl, H. and Rath, T. (2004) Mutagenic and cytotoxic effects of immunosuppressive drugs on human lymphocyte cultures. Exp Clin Transplant 2, 273-279, PubMed: 15859941
137. Namazi, M.R. (2003) The potential efficacy of thalidomide in the treatment of recalcitrant alopecia areata. Med Hypotheses 60, 513-514, PubMed: 12615511
138. Baranda, L. et al. (2005) Severe and unresponsive HIV-associated alopecia areata successfully treated with thalidomide. Acta Derm Venereol 85, 277-278, PubMed: 16040426
139. Shohat, M. et al. (2005) In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101. Clin Exp Dermatol 30, 432-434, PubMed: 15953089
140. Farina, C. et al. (2005) Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet Neurol 4, 567-575, PubMed: 16109363
141. McElwee, K.J. et al. (2003) The pathogenesis of alopecia areata in rodent models. J Investig Dermatol Symp Proc 8, 6-11, PubMed: 12894987
142. Ito, T. et al. (2004) Collapse and restoration of MHC class-I-dependent immune privilege: Exploiting the human hair follicle as a model. Am J Pathol 164, 623-634, PubMed: 14742267
143. Paus, R., Nickoloff, B.J. and Ito, T. (2005) A 'hairy' privilege. Trends Immunol 26, 32-40, PubMed: 15629407
144. McElwee, K.J. et al. (2002) Resistance to alopecia areata in C3H/HeJ mice is associated with increased expression of regulatory cytokines and a failure to recruit CD4+ and CD8+ cells. J Invest Dermatol 119, 1426-1433, PubMed: 12485450
145. Zoller, M. et al. (2004) Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients. J Autoimmun 23, 241-256, PubMed: 15501395
146. Mayer, L. and Shao, L. (2004) Therapeutic potential of oral tolerance. Nat Rev Immunol 4, 407-419, PubMed: 15173830
147. Zoller, M. et al. (2002) Transient CD44 variant isoform expression and reduction in CD4(+)/CD25(+) regulatory T cells in C3H/HeJ mice with alopecia areata. J Invest Dermatol 118, 983-992, PubMed: 12060392
148. Huber, S. et al. (2004) Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. J Immunol 173, 6526-6531, PubMed: 15557141
149. Tang, Q. et al. (2004) In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199, 1455-1465, PubMed: 15184499
150. McElwee, K.J. et al. (2005) What can we learn from animal models of Alopecia areata? Dermatology 211, 47-53, PubMed: 15983437
151. Price, V.H. (2003) Therapy of alopecia areata: On the cusp and in the future. J Investig Dermatol Symp Proc 8, 207-211, PubMed: 14582675
152. Ormerod, A.D. (2003) Alefacept. Biogen. Curr Opin Investig Drugs 4, 608-613, PubMed: 12833658
153. Leonardi, C.L. (2003) Efalizumab: An overview. J Am Acad Dermatol 49, S98-104, PubMed: 12894132
154. Klinkhoff, A. (2004) Biological agents for rheumatoid arthritis: targeting both physical function and structural damage. Drugs 64, 1267-1283, PubMed: 15200343
155. Sauder, D.N. and Mamelak, A.J. (2004) Understanding the new clinical landscape for psoriasis: A comparative review of biologics. J Cutan Med Surg 8, 205-212, PubMed: 16091996
156. Freyschmidt-Paul, P. et al. (2006) Interferon-gamma deficient mice are resistant to the development of alopecia areata. Br J Dermatol (in press)
157. Skurkovich, B. and Skurkovich, S. (2006) Inhibition of IFN-gamma as a method of treatment of various autoimmune diseases, including skin diseases. Ernst Schering Res Found Workshop 1-27, PubMed: 16329644
158. Freyschmidt-Paul, P. et al. (2000) Treatment with an anti-CD44v10-specific antibody inhibits the onset of alopecia areata in C3H/HeJ mice. J Invest Dermatol 115, 653-657, PubMed: 10998138
159. Yano, S. et al. (2002) Analysis of the expression of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous lymphocytes of alopecia areata patients. Acta Derm Venereol 82, 82-85, PubMed: 12125957
160. Freyschmidt-Paul, P. et al. (2003) Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice. J Investig Dermatol Symp Proc 8, 104-108, PubMed: 12895005
161. Jantunen, E. and Luosujarvi, R. (2005) Stem cell transplantation in autoimmune diseases: An update. Ann Med 37, 533-541, PubMed: 16278166
162. Weissman, I. (2005) Stem cell research: Paths to cancer therapies and regenerative medicine. Jama 294, 1359-1366, PubMed: 16174694
163. Freyschmidt-Paul, P. et al. (2003) Alopecia areata: Treatment of today and tomorrow. J Investig Dermatol Symp Proc 8, 12-17, PubMed: 12894988
164. Walker, M.R. et al. (2005) De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci U S A 102, 4103-4108, PubMed: 15753318
165. Cotsarelis, G. and Millar, S.E. (2001) Towards a molecular understanding of hair loss and its treatment. Trends Mol Med 7, 293-301, PubMed: 11425637