Alopecia areata susceptibility in rodent models

Journal of Investigative Dermatology Symposium Proceedings

Volumn 8, Issue 2, 2003, Pages 182-187

  McElwee, Kevin J ^a   Freyschmidt Paul, Pia ^a   Zöller, Margot ^b,c   Hoffmann, Rolf ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Autoimmune disease; Inflammation; Mouse model

Indexed keywords

CD4 ANTIGEN; CYTOKINE; FAS ANTIGEN; FAS LIGAND;

ALOPECIA AREATA; ANTIGEN PRESENTATION; CONFERENCE PAPER; DISEASE COURSE; DISEASE PREDISPOSITION; FLOW CYTOMETRY; HAIR GROWTH; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPH NODE; LYMPHOCYTE ACTIVATION; NONHUMAN; REGULATORY MECHANISM; RODENT; SKIN;

EID: 0141707019     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1087-0024.2003.00806.x     Document Type: Conference Paper

References (89)

1. Albert ML, Sauter B, Bhardwaj N: Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392:86-89, 1998
2. de Andrade M, Jackow CM, Dahm N, Hordinsky M, Reveille JD, Duvic M: Alopecia areata in families: Association with the HLA locus. J Invest Dermatol Symp Proc 4:220-223, 1999
3. + T cells rcgulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol 166:3008-3018, 2001
4. Balasa B, Van Gunst K, Jung N, et al: Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules. J Immunol 165:2841-2849, 2000
5. Bigazzi PE: Autoimmunity and heavy metals. Lupus 3:449-453, 1994
6. Bröcker EB, Echternacht-Happle K, Hamm H, Happle R: Abnormal expression of class I and class II major histocompatibility antigens in alopecia arcata: Modulation by topical immunotherapy. J Invest Dermatol 88:564-568, 1987
7. Bystryn J-C, Tamesis J: Immunological aspects of hair loss. J Invest Dermatol 96:88s-89s, 1991
8. Carroll JM, McElwee KJ, King LE, Byrne MC, Sundberg JP: Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol 119:392-402, 2002
9. Colombe BW, Lou CD, Price VH: The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Invest Dermatol Symp Proc 4:216-219, 1999
10. Colon EA, Popkin MK, Callies AL, Dessert NJ, Hordinsky MK: Lifetime prevalence of psychiatric disorders in patients with alopecia areata. Compr Psychiatry 32:245-251, 1991
11. De Waard-van der Spek FB, Oranje AP, De Raeymaecker DM, Peereboom-Wynia JD: Juvenile versus maturity-onset alopecia areata - A comparative retrospective clinical study. Clin Exp Dermatol 14:429-433, 1989
12. Eichmüller S, van der Veen C, Moll I, Hermes B, Hofmann U, Muller-Rover S, Paus R: Clusters of perifollicular macrophages in normal murine skin: physiological degeneration of selected hair follicles by programmed organ deletion. J Histochem Cytochem 46:361-370, 1998
13. Elenkov IJ, Chrousos GP: Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci 966:290-303, 2002
14. Elkayam O, Yaron M, Caspi D: Minocycline-induced antoimmune syndromes: An overview. Semin Arthritis Rheum 28:392-397, 1999
15. Fonteneau JF, Larsson M, Bhardwaj N: Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses. Curr Opin Immnol 14: 471-477, 2002
16. lpr mice are not susceptible to alopecia areata after grafting of alopecia areata-affected skin from C3H/HeJ Mice. J Invest Dermatol Symp Proc 8: 104-108, 2003
17. Freyschmidt-Paul P, McElwee KJ, Kissling S, Wenzel E, Sundberg JP, Happle R, Hoffmann R: Interleukin-10 deficient mice are less susceptible to the induction of alopecia areata. J Invest Dermatol 119:980-982, 2002
18. +CD25 cells regulate CD8 cell anergy in neonatal tolerant mice. Transplant 68:1891-1897, 1999
19. Gilhar A, Landau M, Assy B, Shalaginov R, Serafimovich S, Kalish RS: Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdc (scid) mice. Arch Dermatol 138:916-922, 2002
20. Gilhar A, Ullmann Y, Berkutzki T, Assy B, Kalish RS: Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101:62-67, 1998
21. Goldsmith LA: Summary of alopecia areata research workshop and future research directions. J Invest Dermatol 96:98s-100s, 1991
22. Griffiths MM, Remmers EF: Genetic analysis of collagen-induced arthritis in rats: A polygenic model for rheumatoid arthritis predicts a common framework of cross-species inflammatory/autoimmune disease loci. Immunol Rev 184:172-183, 2001
23. von Herrath MG, Allison J, Miller JF, Oldstone MB: Focal expression of interleukin-2 does not break unresponsiveness to 'self' (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response. J Clin Invest 95:477-485, 1995
24. Hiemstra HS, Schloot NC, van Veelen PA, et al: Cytomegalovirus in autoimmunity. T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 98:3988-3991, 2001
25. Hoffmann R, Happle R: Alopecia areata. 1: Clinical aspects, etiology, pathogenesis. Hautarzt 50:W222-W231, 1999
26. Holsapple MP: Autoimmunity by pesticides a critical review of the state of the science. Toxicol Lett 127:101-109, 2002
27. Horwitz MS, Bradley LM, Harbertson J, Krahl T, Lee J, Sarvetnick N: Diabetes induced by Coxsackie virus. Initiation by bystander damage and not molecular mimicry. Nat Med 4:781-785, 1998
28. Ikeda T: A new dassification of alopecia areata. Dermatologica 131:421-445, 1965
29. Ikeda T: Produced alopecia areata based on the focal infection theory and mental motion theory. Dermatologica 134:1-11, 1967
30. Inaba K, Turley S, Yamaide F, et al: Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med 188:2163-2173, 1998
31. Itoh N, Imagawa A, Hanafusa T, et al: Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice. J Exp Med 186:613-618, 1997
32. Jackow C, Puffer N, Hordinsky M, Nelson J, Tarrand J, Duvic M: Alopecia areata and cytomegalovirus infection in twins: Genes versus environment? J Am Acad Dermatol 38:418-425, 1998
33. Karpus WJ, Swanborg RH: CD4 suppressor cells differentially affect the production of IFN-γ by effector cells of experimental autoimmune encephalomyelitis. J Immunol 143:3492-3497, 1989
34. Karrer U, Althage A, Odermatt B, et al: On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11 (-)/-) mutant mice. J Exp Med 185: 2157-2170, 1997
35. Kassiotis G, Kollias G: Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p35 TNF receptor level: Implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med 193:427-434, 2001
36. Kavak A, Yesildal N, Parlak AH: Effect of two consecutive earthquakes on outbreaks of alopecia areata. J Dermatol 29:414-418, 2002
37. Larsson M, Fonteneau JF, Bhardwaj N: Dendritic cells resurrect antigens from dead cells. Trends Immunol 22:141-148, 2001
38. Lawrence DA, McCabe MJ Jr: Immunomodulation by metals. Int Immunopharmacol 2:293-302, 2002
39. Liakopoulou M, Alifieraki T, Katideniou A, Kakonrou T, Tselalidou E, Tsiantis J, Stratigos J: Children with alopecia areata. Psychiatric symptomatology and life events. J Am Acad Child Adolesc Psychiatry 36:678-684, 1997
40. Lindner G, Botchkarev VA, Botchkareva NV, Ling G, van der Veen C, Plus R: Analysis of apoptosis during hair follicle regression (catagen). Am J Pathol 151:1601-1617, 1997
41. Ludewig B, Junt T, Hengartner H, Zinkernagel RM: Dendritic cells in autoimmune diseases. Curr Opin Immunol 13:657-662, 2001
42. Marrack P, Kappler J, Kotzin BL: Antoimmune disease. Why and where it occurs. Nat Med 7:899-905, 2001
43. McDonald AH, Swanborg RH: Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis. J Immunol 140:1132-1138, 1988
44. McElwee KJ: Dundee experimental bald rat (DEBR) model for alopecia areata. In: Chan LS (ed). Animal Models of Human Inflammatory Skin Diseases. Boca Raton: CRC Press, in press
45. McElwee KJ, Boggess D, Burgett B, Bates R, Bedigan HG, Sundberg JP, King LE: Murine cytomegalovirus is not associated with alopecia areata in C3H/HeJ mice. J Invest Dermatol 110:986-987, 1998c
46. McElwee KJ, Boggess D, King LE Jr, Sundberg JP: Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111:797-803, 1998b
47. McElwee KJ, Boggess D, Miller J, King LE Jr, Sundberg JP: Spontaneous alopecia arcata-like hair loss in one congenic and seven inbred laboratory mouse strains. J Invest Dermatol Symp Proc 4:202-206, 1999a
48. McElwee KJ, Boggess D, Olivry T, et al: Comparison of alopecia areata in human and nonhuman mammalian species. Pathobiology 66:90-107, 1998a
49. McElwee KJ, Hoffmann R: Alopecia areata - Animal, models. Clin Exp Dermatol 27:414-421, 2002
50. + cells. J Invest Dermatol 119:1426-1433, 2002
51. McElwee KJ, Silva K, Beamer WG, King LE Jr, Sundberg JP: Melanocyte and gonad activity as potential severity modifying factors in C3H/HeJ mouse alopecia areata. Exp Dermatol 10:420-429, 2001
52. + T cells restores hair growth in the DEBR model for alopecia areata. Br J Dermatol 135: 211-217, 1996
53. + T cells. Br J Dermatol 140:432-437, 1999c
54. McElwee KJ, Tobin DJ, Bystryn J-C, King LE, Sundberg JP: Alopecia areata: An autoimmune disease? Exp Dermatol 8:371-379, 1999b
55. Mehlman RD, Griesemer RD: Alopecia areata in the very young. Am J Psychiatry 125:605-614, 1968
56. Messenger AG, Bleehen SS: Expression of HLA-DR by anagen hair follicles in alopecia areata. J Invest Dermatol 85:569-572, 1985
57. Motyka B, Korbutt G, Pinkoski MJ, et al: Mannose 6-phosphate/ insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell 103:491-500, 2000
58. Muller SA, Winkelmann RK: Alopecia areata. An evaluation of 736 patients. Arch Dermatol 88:290-297, 1963
59. Mustafa MI, Diener P, Höjeberg B, Van der Meide P, Olsson T: T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats. J Neuroimmunol 31:163-177, 1991
60. Nepom GT, Erlich H: MHC class-II molecules and autoimmunity. Annu Rev Immunol 9:493-525, 1991
61. Oldstone MB: Molecular mimicry and immune-mediated diseases. FASEB J 12:1255-1265, 1998
62. Parakkal PF: Role of macrophages in collagen resorption during hair growth cycle. J Ultrastruct Res 29:210-217, 1969
63. Paus R: Control of the hair cycle and hair diseases as cycling disorders. Curr Opin Dermatol 3:248-258, 1996
64. Paus R, Christoph T, Muller-Rover S: Immunology of the hair follicle: A short journey into terra incognita. J Invest Dermatol Symp Proc 4:226-234, 1999
65. Paus R, Slominski A, Czarnetzki BM: Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J Biol Med 66:541-554, 1993
66. Penders AJ: Alopecia areata and atopy. Dermatologica 136:395-399, 1968
67. Piguet PF, Vesin C, Guo J, Donati Y, Barazzone C: TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53. Eur J Immunol 28:3499-3505, 1998
68. Randall VA: Is alopecia areata an autoimmune disease? Lancet 358:1922-24, 2001
69. Ranki A, Kianto U, Kanerva L, Tolvanen E, Johansson E: Immunohistochemical and electron microscopic characterization of the cellular infiltrate in alopecia (areata, totalis, and universalis). J Invest Dermatol 83:7-11, 1984
70. Regner M, Lambert PH: Autoimmunity through infection or immunization? Nat Immunol 2:185-188, 2001
71. Russell JH, Ley TJ: Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 20:323-370, 2002
72. Sabouraud R: Sur les origines de la pelade. Annales Dermatologie Dermatologie Syphiligraphie 3:253-277, 1896
73. Siegel RM, Chan FK, Chun HJ, Lenardo MJ: The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 1:469-474, 2000
74. Skinner RB Jr, Light WH, Bale GF, Rosenberg EW, Leonardi C: Alopecia areata and presence of cytomegalovirus DNA. JAMA 273:1419-1420, 1995
75. Smyth JR Jr, McNeil M: Alopecia areata and universalis in the Smyth chicken model for spontaneous autoimmune vitiligo. J Invest Dermatol Symp Proc 4:211-215, 1999
76. Su X, Hu Q, Kristan JM, et al: Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol 164:2523-2532, 2000
77. Sundberg JP, Boggess D, Silva KA: Major locus on mouse chromosome 17 and minor locus on chromosome 9 are Linked with alopecia areata in C3H/HeJ Mice. J Invest Dermatol 120:771-775, 2003
78. Sundberg JP, Cordy WR, King LE Jr: Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102:847-856, 1994
79. Suri-Payer E, Amar AZ, Thornton AM, Shevach EM: CD4+/CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 160:1212-1218, 1998
80. Tobin DJ, Orentreich N, Bystryn J-C: Autoantibodies to hair follicles in normal individuals. Arch Dermatol 130:395-396, 1994b
81. Tobin DJ, Orentreich N, Fenton DA, Bystryn J-C: Antibodies to hair follicles in alopecia areata. J Invest Dermatol 102:721-724, 1994a
82. Tobin DJ, Sundberg JP, King LE Jr, Boggess D, Bystryn JC: Autoantibodies to hair follicles in C3H/HeJ mice with alopecia areata-like hair loss. J Invest Dermatol 109:329-333, 1997
83. Weedon D, Strutton G: Apoptosis as the mechanism of the involution of hair follicles in catagen transformation. Acta Derm Venereol 61:335-339, 1981
84. Weise K, Kretzschmar L, John SM, Hamm H: Topical immunotherapy in alopecia areata. Anamnestic and clinical criteria of prognostic significance. Dermatology 192:129-133, 1996
85. Westgate GE, Craggs RI, Gibson WT: Immune privilege in hair growth. J Invest Dermatol 97:417-420, 1991
86. Wucherpfennig KW: Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Curr Opin Immunol 13:650-656, 2001
87. Wucherpfennig KWYuB, Bhol K, et al: Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity. Charged residues of a single MHC binding pocket confer selective presentation of self peptides in pemphigus vulgaris. Proc Natl Acad Sci USA 92:11935-11939, 1995
88. Zhang JG, Oliver RF: Immunohistological study of the development of the cellular infiltrate in the pelage follicles of the DEBR model for alopecia areata. Br J Dermatol 130:405-414, 1994
89. Zöller M, McElwee KJ, Engel P, Hoffmann R: Transient CD44 variant isoform expression and reduction in CD4 (+)/CD25 (+) regulatory T cells in C3H/HeJ mice with alopecia areata. J Invest Dermatol 118:983-992, 2002