The DEBR rat, alopecia areata and autoantibodies to the hair follicle

British Journal of Dermatology

Volumn 134, Issue 1, 1996, Pages 55-63

  McElwee, K J ^a   Pickett, P ^a   Oliver, R F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ALOPECIA AREATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HAIR FOLLICLE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030028886     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.1996.tb07840.x     Document Type: Article

References (41)

1. Price VH. Alopecia areata: clinical aspects. J Invest Dermatol 1991; 96 (Suppl.): 68s.
2. Editorial: Alopecia areata - an autoimmune disease? Lancet 1984; i: 1335-6.
3. Perret C, Weisner-Menzel L, Happle R. Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata. Acta Derm Venerol 1984; 64: 26-50.
4. Michie HJ, Jahoda CAB, Oliver RF, Johnson BE. The DEBR rat: an animal model of human alopecia areata. Br J Dermatol 1991; 125: 94-100.
5. Price VH, Khoury EL. Alopecia areata. Prog Dermatol 1991; 25: 1-7.
6. Muller SA, Winkelmann RK. Alopecia areata. An evaluation of 736 patients. Arch Dermatol 1963; 88: 290-7.
7. Cunliffe WJ, Hall R, Stevenson CJ, Weightman D. Alopecia areata, thyroid disease and autoimmunity. Br J Dermatol 1969; 81: 877-81.
8. Main RA, Robbie RB, Gray ES et al. Smooth muscle antibodies and alopecia areata. Br J Dermatol 1975; 92: 389-93.
9. Rose NR. Characteristics of autoimmune disease. J Invest Dermatol 1991; 96 (Suppl.): 87s.
10. Kern F, Hoffman WH, Hambrick GW, Blizzard RM. Alopecia areata. Immunologic studies and treatment with prednisone. Arch Dermatol 1973; 107: 407-12.
11. Schenk EA, Schneider P, Brown AC. Autoantibodies in alopecia and vitiligo. In: Hair, Trace Elements and Human Illness (Brown A, Crounse R, eds). New York: Praeger, 1980; 334-42.
12. Friedmann PS. Alopecia areata and autoimmunity. Br J Dermatol 1981; 105: 153-7.
13. Galbraith GMP, Thiers BH, Vasily DB, Fudenberg HH. Immunological profiles in alopecia areata. Br J Dermatol 1984; 110: 163-70.
14. Zauli D, Veronesi S, Lama L et al. Alopecia areata: a heterogeneous disease. Lancet 1984; ii: 1154.
15. Bettrele C, Peserico A, Del Prete G, Trisotto A. Autoantibodies in alopecia areata. Arch Dermatol 1975; 111: 927-8.
16. Cochran REI, Thomson J, MacSween RNM. An autoantibody profile in alopecia totalis and diffuse alopecia. Br J Dermatol 1976; 95: 61-5.
17. Muller HK, Rook AJ, Kubba R. Immunohistology and autoantibody studies in alopecia areata. Br J Dermatol 1980; 102: 609-10.
18. Klaber MR, Munro DD. Alopecia areata: immunofluorescence and other studies. Br J Dermatol 1978; 99: 383-6.
19. Igarashi R, Takeuchi S, Sato Y. Immunofluorescent studies of complement C3 in the hair follicles of normal scalp and of scalp affected by alopecia areata. Acta Derm Venereol (Stockh) 1980; 60: 33-7.
20. Calver NS, MacDonald Hull S, Parkin SM et al. Autoantibodies in alopecia areata. Br J Dermatol 1992; 127: 432.
21. Tobin DJ, Orentreich N, Fenton DA, Bystryn J-C. Antibodies to hair follicles in alopecia areata. J Invest Dermatol 1994; 102: 721-4.
22. Michie HJ. The DEBR rat: an animal model of human alopecia areata. Thesis. University of Dundee 1989.
23. Michie HJ, Jahoda CAB, Oliver RF, Poulton TA. Immunological studies on the alopecic (DEBR) rat. Br J Dermatol 1990; 123: 557-67.
24. Zhang JG, Oliver RF. Immunohistological study of the development of the cellular infiltrate in the pelage follicles of the DEBR model for alopecia areata. Br J Dermatol 1994; 130: 405-14.
25. Oliver RF, Jahoda CAB, Horne KA et al. The DEBR rat model for alopecia areata. J Invest Dermatol 1991; 96 (Suppl.): 97s.
26. Gollinck H, Orfanos CE, Alopecia areata: pathogenesis and clinical picture. In: Hair and Hair Diseases (Orfanos CE, Happle R, eds). Berlin: Springer-Verlag, 1990; 529-69.
27. Ollier W, Symmons DPM. In: Autoimmunity (Read AP, Brown T eds). Oxford: Bios Scientific Publishers, 1992; 74.
28. Sainsbury TSL, Duncan JI, Whiting PH et al. Differential effects of FK506 and cyclosporine on hair regrowth in the DEBR model of alopecia areata. Transplant Proc 1991; 23: 3332-4.
29. Oliver RF, Lowe JG. Oral cyclosporin A restores hair growth in the DEBR rat model for alopecia areata. Clin Exp Dermatol 1995; 20: 127-31.
30. Brandtzaeg P. Prolonged incubation time in immunohistochemistry: effects on fluorescence staining of immunoglobulins and peithelial components in ethanol- and formaldehyde-fixed paraffin-embedded tissues. J Histochem Cytochem 1981; 29: 1302-15.
31. Sofroniéw MV, Schrell U. Long-term storage and regular repeated use of diluted antisera in glass staining jars for increased sensitivity, reproducibility and convenience of single- and two-color light microscopic immunocytochemistry. J Histochem Cytochem 1982; 30: 504-11.
32. Jahoda CAB, Reynolds AJ. Dermal-epidermal interactions - follicle-derived cell populations in the study of hair growth mechanisms. J Invest Dermatol 1993; 101 (Suppl.): 33s-8s.
33. Franke WW, Heid H. Desmsomal proteins and cytokeratins in the hair follicle. In: The Biology of Wool and Hair (Rogers GE, Reis PJ, Ward KA, Marshall RC, eds). London: Chapman and Hall, 1989; 403-16.
34. Lane EB, Bartek J, Purkis PE, Leigh IM. Keratin antigens in differentiating skin. Ann NY Acad Sci 1985; 455: 241-58.
35. Van Baar HMJ, Van Vlijmen IMJJ, Ramaekers FCS et al. Cytokeratin expression in alopecia areata hair follicles. Acta Derm Venereol (Stockh) 1994; 74: 28-32.
36. Strauss AJL, Seegal BC, Hsu KC et al. Immunofluorescence demonstration of a muscle binding complement-fixing serum globulin fraction in myasthenia gravis. Proc Soc Exp Biol Med 1960; 105: 184-91.
37. Wekerle H. The thymus in myasthenia gravis. Ann NY Acad Sci 1993; 681: 47-55.
38. Heid HW, Moll I, Franke WW. Patterns of expression of trichocytic and epithelial cytokeratin in mammalian tissues. 2. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine-tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum). Differentiation 1988; 37: 215-30.
39. Nunzi E, Hammerlinck F, Cormane RH. Immunopathological studies on alopecia areata. Arch Dermatol Res 1980; 269: 1-11.
40. Beck JS. Variations in the morphological patterns of 'autoimmune' nuclear fluorescence. Lancet 1961; i: 1203-5.
41. Tan EM. Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv immunol 1989; 44: 93-151.