Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a β3-adrenergic agonist and lack of effect of leptin

Molecular and Cellular Endocrinology

Volumn 176, Issue 1-2, 2001, Pages 85-90

  Gómez Ambrosi, Javier ^a   Frühbeck, Gema ^b   Alfredo Martinez J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

3 adrenergic agonist; Brown adipose tissue; Leptin; PGC 1; PPAR 2; Rat; Uncoupling protein

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRECADRINE; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; LIPOLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMOGENESIS;

ADIPOSE TISSUE, BROWN; ADRENERGIC BETA-AGONISTS; ANIMALS; BENZYL ALCOHOLS; BODY TEMPERATURE; CARRIER PROTEINS; FASTING; FATTY ACIDS, NONESTERIFIED; ION CHANNELS; LEPTIN; MALE; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 0343431408     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00451-8     Document Type: Article

References (28)

1. Ahima R.S., Flier J.S. Leptin. Annu. Rev. Physiol. 62:2000;413-437.
2. 3-adrenoceptors. Life Sci. 59:1996;L141-L146.
3. 4-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-γ coactivator-1. Biochem. Biophys. Res. Commun. 261:1999;870-876.
4. 3-adrenoceptors in intact brown adipocytes of the rat. Br. J. Pharmacol. 114:1995;275-282.
5. 3-adrenoceptor mRNA in rat tissues. Br. J. Pharmacol. 117:1996;210-216.
6. Frühbeck G., Aguado M., Gómez-Ambrosi J., Martínez J.A. Lipolytic effect of in vivo leptin administration on adipocytes of lean and ob/ob mice, but not db/db mice. Biochem. Biophys. Res. Commun. 250:1998;99-102.
7. 3-adrenoceptor agonist. Biochem. Pharmacol. 54:1997;121-131.
8. 3-adrenergic agonist, upregulates muscle uncoupling protein-3 messenger RNA expression: short-term thermogenic interactions. Cell. Mol. Life Sci. 55:1999;992-997.
9. 3-adrenergic receptor induces adipocyte-like features in CHO/K1 fibroblasts. J. Cell Sci. 112:1999;3791-3797.
10. Guardiola-Díaz H.M., Rehnmark S., Usuda N., et al. Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. J. Biol. Chem. 274:1999;23 368-23 377.
11. Haynes W.G., Morgan D.A., Walsh S.A., Mark A.L., Sivitz W.I. Receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100:1997;270-278.
12. Himms-Hagen J. Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4:1990;2890-2898.
13. Kelly L.J., Vicario P.P., Thompson G.M., et al. Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology. 139:1998;4920-4927.
14. Kubota N., Terauchi Y., Miki H., et al. PPARg mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4:1999;597-609.
15. Lowell B.B., Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature. 404:2000;652-660.
16. Lowell, B.B., Susulic, V.S., Hamann, A., et al., 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue, Nature 366, 740-742.
17. Pelleymounter M.A., Cullen M.J., Baker M.B., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
18. Puigserver P., Picó C., Stock M.J., Palou A. Effect of selective β-adrenoceptor stimulation on UCP synthesis in primary cultures of brown adipocytes. Mol. Cell. Endocrinol. 117:1996;7-16.
19. Puigserver P., Wu Z., Park C.W., et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92:1998;829-839.
20. Qian H., Hausman G.J., Compton M.M., et al. Leptin regulation of peroxisome proliferator-activated receptor-γ, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues. Biochem. Biophys. Res. Commun. 246:1998;660-667.
21. Ricquier D., Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345:2000;161-179.
22. Sanigorski A., Cameron-Smith D., Lewandowski P., et al. Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus. J. Endocrinol. 164:2000;45-50.
23. 3-adrenergic agonist BRL 35135 and metformin in obese fa/fa Zucker rats. Biochem. Biophys. Res. Commun. 246:1998;899-904.
24. Scarpace P.J., Matheny M., Pollock B.H., Tumer N. Leptin increases uncoupling protein expression and energy expenditure. Am. J. Physiol. 273:1997;E226-E230.
25. 3-adrenoceptor agonists. Biochem. Pharmacol. 50:1995;601-608.
26. Vidal-Puig A., Jimenez-Linan M., Lowell B.B., et al. Regulation of PPARγ gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97:1996;2553-2561.
27. Wu Z., Puigserver P., Andersson U., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 98:1999;115-124.
28. 3 adrenergic receptor agonist treatment. Biochem. Biophys. Res. Commun. 253:1998;85-91.