N-Acylated sulfonamide sodium salt: A prodrug of choice for the bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamide class of COX-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 15, 2006, Pages 3921-3926

  Singh, Sunil Kumar ^a   Vobbalareddy, Saibaba ^a   Kalleda, Srinivasa Rao ^a   Casturi, Seshagiri Rao ^a   Mullangi, Ramesh ^a   Ramanujam, Rajagopalan ^a   Yeleswarapu, Koteswar Rao ^a   Iqbal, Javed ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

1,5 Diarylpyrazoles; COX 2 inhibitors; Parenteral administration; Prodrugs

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CARRAGEENAN; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ETORICOXIB; KETOROLAC; NIMESULIDE; PARECOXIB; PRODRUG; PYRAZOLE DERIVATIVE; ROFECOXIB; SODIUM; VALDECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; PAW EDEMA; RAT; SCREENING TEST;

ACYLATION; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; PRODRUGS; RATS; SULFONAMIDES;

EID: 33745143300     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.028     Document Type: Article

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