메뉴 건너뛰기




Volumn 2, Issue 3-4, 2006, Pages 160-165

Enprofylline protects motor neurons from in vitro excitotoxic challenge

Author keywords

Adenosine A2a receptor; Amyotrophic lateral sclerosis; Brain derived neurotrophic factor; Transactivation; Trk receptor

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR STIMULATING AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ENPROFYLLINE;

EID: 33744817959     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000089621     Document Type: Article
Times cited : (11)

References (51)
  • 1
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney JW: Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969;164:719-721.
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 2
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and disease of the nervous system
    • Choi DW: Glutamate neurotoxicity and disease of the nervous system. Neuron 1988;1:623-634
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 3
    • 0025299819 scopus 로고
    • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
    • Rothstein JD, Tsai G, Kuncl RW, et al: Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:18-25.
    • (1990) Ann Neurol , vol.28 , pp. 18-25
    • Rothstein, J.D.1    Tsai, G.2    Kuncl, R.W.3
  • 4
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW: Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;326:1464-1468.
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 5
    • 0029441620 scopus 로고
    • Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis
    • Rothstein JD: Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol 1995;68:7-20.
    • (1995) Adv Neurol , vol.68 , pp. 7-20
    • Rothstein, J.D.1
  • 7
    • 0034307730 scopus 로고    scopus 로고
    • AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability
    • Vandenberghe W, Ihle EC, Patneau DK, Robberecht W, Brorson JR: AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J Neurosci 2000;20:7158-7166.
    • (2000) J Neurosci , vol.20 , pp. 7158-7166
    • Vandenberghe, W.1    Ihle, E.C.2    Patneau, D.K.3    Robberecht, W.4    Brorson, J.R.5
  • 8
    • 19944428649 scopus 로고    scopus 로고
    • Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    • Rothstein JD, Patel S, Regan MR, et al: Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 2005;433:73-77.
    • (2005) Nature , vol.433 , pp. 73-77
    • Rothstein, J.D.1    Patel, S.2    Regan, M.R.3
  • 9
    • 0030777650 scopus 로고    scopus 로고
    • Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS
    • Durham HD, Roy J, Dong L, Figlewicz DA: Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS. J Neuropathol Exp Neurol 1997;56:523-530.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 523-530
    • Durham, H.D.1    Roy, J.2    Dong, L.3    Figlewicz, D.A.4
  • 10
    • 0032924609 scopus 로고    scopus 로고
    • Excitotoxic death of a subset of embryonic rat motor neurons in vitro
    • Fryer HJL, Knox RJ, Strittmatter SM, Kalb RG: Excitotoxic death of a subset of embryonic rat motor neurons in vitro. J Neurochem 1999;72:500-513.
    • (1999) J Neurochem , vol.72 , pp. 500-513
    • Fryer, H.J.L.1    Knox, R.J.2    Strittmatter, S.M.3    Kalb, R.G.4
  • 11
    • 0033977281 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway
    • Fryer HJL, Wolf DH, Knox RJ, et al: Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway. J Neurochem 2000;74:582-595.
    • (2000) J Neurochem , vol.74 , pp. 582-595
    • Fryer, H.J.L.1    Wolf, D.H.2    Knox, R.J.3
  • 12
    • 0037347393 scopus 로고    scopus 로고
    • BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB
    • Hu P, Kalb RG: BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB. J Neurochem 2003;84:1421-1430.
    • (2003) J Neurochem , vol.84 , pp. 1421-1430
    • Hu, P.1    Kalb, R.G.2
  • 13
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    • Cleveland DW, Rothstein JD: From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2001;2:806-819.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 14
    • 0028544566 scopus 로고
    • Oxidative stress and motoneuron disease
    • Sendtner M, Thoenen H: Oxidative stress and motoneuron disease. Curr Biol 1994;4:1036-1039.
    • (1994) Curr Biol , vol.4 , pp. 1036-1039
    • Sendtner, M.1    Thoenen, H.2
  • 15
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LI, Miller TM, Cleveland DW: Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 2004;27:723-749.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 16
    • 9644255989 scopus 로고    scopus 로고
    • A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
    • Barbeito LH, Pehar M, Cassina P, et al: A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. Brain Res Brain Res Rev 2004;47:263-274.
    • (2004) Brain Res Brain Res Rev , vol.47 , pp. 263-274
    • Barbeito, L.H.1    Pehar, M.2    Cassina, P.3
  • 17
    • 16244389278 scopus 로고    scopus 로고
    • Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: Implications for amyotrophic lateral sclerosis
    • Cassina P, Pehar M, Vargas MR, et al: Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem 2005;93:38-46.
    • (2005) J Neurochem , vol.93 , pp. 38-46
    • Cassina, P.1    Pehar, M.2    Vargas, M.R.3
  • 18
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • ALS/Riluzole Study Group
    • Bensimon G, Lacomblez L, Meininger V: A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med 1994;330:585-591.
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 19
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • USA
    • Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW: Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993;90:6591-6595.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 20
    • 0028331599 scopus 로고
    • Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
    • Smeyne RJ, Klein R, Schnapp A, et al: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 1994;368:246-249.
    • (1994) Nature , vol.368 , pp. 246-249
    • Smeyne, R.J.1    Klein, R.2    Schnapp, A.3
  • 21
    • 0027491104 scopus 로고
    • Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
    • Klein R, Smeyne RJ, Wurst W, et al: Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 1993;75:113-122.
    • (1993) Cell , vol.75 , pp. 113-122
    • Klein, R.1    Smeyne, R.J.2    Wurst, W.3
  • 22
    • 0028329355 scopus 로고
    • Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements
    • Klein R, Silos-Santiago I, Smeyne RJ, et al: Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 1994;368:249-251.
    • (1994) Nature , vol.368 , pp. 249-251
    • Klein, R.1    Silos-Santiago, I.2    Smeyne, R.J.3
  • 23
    • 0027303741 scopus 로고
    • Recombinant human insulin-like growth factor I exerts a trophic action and confers glutamate sensitivity on glutamate-resistant cerebellar granule cells
    • USA
    • Calissano P, Ciotti MT, Battistini L, et al: Recombinant human insulin-like growth factor I exerts a trophic action and confers glutamate sensitivity on glutamate-resistant cerebellar granule cells. Proc Natl Acad Sci USA 1993;90:8752-8756.
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 8752-8756
    • Calissano, P.1    Ciotti, M.T.2    Battistini, L.3
  • 24
    • 0029150526 scopus 로고
    • 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons
    • 2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. J Neurochem 1995;65:1740-1751.
    • (1995) J Neurochem , vol.65 , pp. 1740-1751
    • Mattson, M.P.1    Lovell, M.A.2    Furukawa, K.3    Markesbery, W.R.4
  • 25
    • 0037637607 scopus 로고    scopus 로고
    • Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats
    • Ellsworth JL, Garcia R, Yu J, Kindy MS: Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats. Stroke 2003;34:1507-1512.
    • (2003) Stroke , vol.34 , pp. 1507-1512
    • Ellsworth, J.L.1    Garcia, R.2    Yu, J.3    Kindy, M.S.4
  • 26
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G, et al: Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 2004;305:239-242.
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3
  • 27
    • 0037974734 scopus 로고    scopus 로고
    • Asialoerythropoietin is a non-erythropoietic cytokine with broad neuroprotective activity in vivo
    • USA
    • Erbayraktar S, Grasso G, Sfacteria A, et al: Asialoerythropoietin is a non-erythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci USA 2003;100:6741-6746.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 6741-6746
    • Erbayraktar, S.1    Grasso, G.2    Sfacteria, A.3
  • 28
    • 0031257758 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 improves both neurological motor and cognitive outcome following experimental brain injury
    • Saatman KE, Contreras PC, Smith DH, et al: Insulin-like growth factor-1 improves both neurological motor and cognitive outcome following experimental brain injury. Exp Neurol 1997;147:418-427.
    • (1997) Exp Neurol , vol.147 , pp. 418-427
    • Saatman, K.E.1    Contreras, P.C.2    Smith, D.H.3
  • 29
    • 11144279290 scopus 로고    scopus 로고
    • The protean actions of neurotrophins and their receptors on the life and death of neurons
    • Kalb R: The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 2005;28:5-11.
    • (2005) Trends Neurosci , vol.28 , pp. 5-11
    • Kalb, R.1
  • 30
    • 0029065517 scopus 로고
    • Potentiated necrosis of cultured cortical neurons by neurotrophins
    • Koh JY, Gwag BJ, Lobner D, Choi DW: Potentiated necrosis of cultured cortical neurons by neurotrophins. Science 1995;268:573-575.
    • (1995) Science , vol.268 , pp. 573-575
    • Koh, J.Y.1    Gwag, B.J.2    Lobner, D.3    Choi, D.W.4
  • 31
    • 0001884447 scopus 로고
    • Cytotoxicity in murine neocortical cell culture
    • Tyson CA, Frazier JM (ed): San Diego, Academic Press
    • Rose K, Goldberg MP, Choi DW: Cytotoxicity in murine neocortical cell culture; in Tyson CA, Frazier JM (ed): In vitro Biological Methods. Methods in Toxicology. San Diego, Academic Press, 1993, pp 46-60.
    • (1993) In Vitro Biological Methods. Methods in Toxicology , pp. 46-60
    • Rose, K.1    Goldberg, M.P.2    Choi, D.W.3
  • 32
    • 0036006816 scopus 로고    scopus 로고
    • Distinctive features of Trk neurotrophin receptor transactivation by G-protein-coupled receptors
    • Lee FS, Rajagopal R, Chao MV: Distinctive features of Trk neurotrophin receptor transactivation by G-protein-coupled receptors. Cytokine Growth Factor Rev 2002;13:11-17.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 11-17
    • Lee, F.S.1    Rajagopal, R.2    Chao, M.V.3
  • 33
    • 0028316048 scopus 로고
    • Phosphorylation of neurofilament H subunit as related to arrangement of neurofilaments
    • Gotow T, Tanaka J: Phosphorylation of neurofilament H subunit as related to arrangement of neurofilaments. J Neurosci Res 1994;37:691-713.
    • (1994) J Neurosci Res , vol.37 , pp. 691-713
    • Gotow, T.1    Tanaka, J.2
  • 34
    • 0030015076 scopus 로고    scopus 로고
    • Motor neurons are selectively vulnerable to AMPA/KA receptor-mediated injury in vitro
    • Carriedo SG, Yin HZ, Weiss JH: Motor neurons are selectively vulnerable to AMPA/KA receptor-mediated injury in vitro. J Neurosci 1996;16:4069-4079.
    • (1996) J Neurosci , vol.16 , pp. 4069-4079
    • Carriedo, S.G.1    Yin, H.Z.2    Weiss, J.H.3
  • 36
    • 0033104429 scopus 로고    scopus 로고
    • Motor neuron degeneration is attenuated in bax-deficient neurons in vitro
    • Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD: Motor neuron degeneration is attenuated in bax-deficient neurons in vitro. J Neurosci Res 1999;55:542-556.
    • (1999) J Neurosci Res , vol.55 , pp. 542-556
    • Bar-Peled, O.1    Knudson, M.2    Korsmeyer, S.J.3    Rothstein, J.D.4
  • 37
    • 1842558602 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
    • Arundine M, Tymianski M: Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 2004;61:657-668.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 657-668
    • Arundine, M.1    Tymianski, M.2
  • 38
    • 3342936513 scopus 로고    scopus 로고
    • Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: Transactivation or parallel pathways?
    • Downward J: Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways? Biochem J 2003;376:e9-e10.
    • (2003) Biochem J , vol.376
    • Downward, J.1
  • 39
    • 0037127297 scopus 로고    scopus 로고
    • Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells
    • Thuringer D, Maulon L, Frelin C: Rapid transactivation of the vascular endothelial growth factor receptor KDR/Flk-1 by the bradykinin B2 receptor contributes to endothelial nitric-oxide synthase activation in cardiac capillary endothelial cells. J Biol Chem 2002;277:2028-2032.
    • (2002) J Biol Chem , vol.277 , pp. 2028-2032
    • Thuringer, D.1    Maulon, L.2    Frelin, C.3
  • 40
    • 10744232199 scopus 로고    scopus 로고
    • Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors
    • Liu J, Liao Z, Camden J, et al: Src homology 3 binding sites in the P2Y2 nucleotide receptor interact with Src and regulate activities of Src, proline-rich tyrosine kinase 2, and growth factor receptors. J Biol Chem 2004;279:8212-8218.
    • (2004) J Biol Chem , vol.279 , pp. 8212-8218
    • Liu, J.1    Liao, Z.2    Camden, J.3
  • 41
    • 0037668195 scopus 로고    scopus 로고
    • 2 receptor prevents apoptosis in dopaminergic cell lines
    • 2 receptor prevents apoptosis in dopaminergic cell lines. Biochem J 2003;373:25-32.
    • (2003) Biochem J , vol.373 , pp. 25-32
    • Nair, V.D.1    Olanow, C.W.2    Sealfon, S.C.3
  • 43
    • 3342884404 scopus 로고    scopus 로고
    • Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes
    • Rajagopal R, Chen ZY, Lee FS, Chao MV: Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes. J Neurosci 2004;24:6650-6658.
    • (2004) J Neurosci , vol.24 , pp. 6650-6658
    • Rajagopal, R.1    Chen, Z.Y.2    Lee, F.S.3    Chao, M.V.4
  • 44
    • 0035853065 scopus 로고    scopus 로고
    • Activation of Trk neurotrophin receptors in the absence of neurotrophins
    • USA
    • Lee FS, Chao MV: Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc Natl Acad Sci USA 2001;98:3555-3560.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 3555-3560
    • Lee, F.S.1    Chao, M.V.2
  • 45
    • 3142707564 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
    • Fischer OM, Giordano S, Comoglio PM, Ullrich A: Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem 2004;279:28970-28978.
    • (2004) J Biol Chem , vol.279 , pp. 28970-28978
    • Fischer, O.M.1    Giordano, S.2    Comoglio, P.M.3    Ullrich, A.4
  • 46
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S, Stavrovskaya IG, Drozda M, et al: Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002;417:74-78.
    • (2002) Nature , vol.417 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3
  • 48
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • Storkebaum E, Lambrechts D, Dewerchin M, et al: Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92.
    • (2005) Nat Neurosci , vol.8 , pp. 85-92
    • Storkebaum, E.1    Lambrechts, D.2    Dewerchin, M.3
  • 49
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar BK, Llado J, Sherkat N, Rothstein JD, Gage FH: Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003;301:839-842.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 51
    • 0344738697 scopus 로고    scopus 로고
    • 2A receptor selective antagonist KW6002: Research and development toward a novel non-dopaminergic therapy for Parkinson's disease
    • 2A receptor selective antagonist KW6002: research and development toward a novel non-dopaminergic therapy for Parkinson's disease. Neurology 2003;61:S97-S100.
    • (2003) Neurology , vol.61
    • Kase, H.1    Aoyama, S.2    Ichimura, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.