BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB

Journal of Neurochemistry

Volumn 84, Issue 6, 2003, Pages 1421-1430

  Hu, Peter ^a   Kalb, Robert G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Amyotrophic lateral sclerosis; BDNF; Excitoxicity; Motorneuron; PI3 Kinase; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; ENZYME SUBUNIT; MOTONEURON; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL;

NASA DISCIPLINE NEUROSCIENCE; NON-NASA CENTER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBODIES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATALYTIC DOMAIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE TRANSFER TECHNIQUES; GENES, DOMINANT; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; SIGNAL TRANSDUCTION; SPINAL CORD;

ANIMALIA;

EID: 0037347393     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01599.x     Document Type: Article

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