메뉴 건너뛰기




Volumn 115, Issue 1-2, 2006, Pages 1-8

The role of protein kinase C-alpha in hematologic malignancies

Author keywords

Acute myelogenous leukemia; Antisense oligonucleotide; Aprinocarsen; Non Hodgkin lymphoma; PKC ; Targeted agents

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; APRINOCARSEN; CAMPTOTHECIN; PACLITAXEL; PROTEIN KINASE C ALPHA; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

EID: 31144449363     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089458     Document Type: Review
Times cited : (20)

References (65)
  • 1
    • 0032784783 scopus 로고    scopus 로고
    • World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting - Airlie House, Virginia, November 1997
    • Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting - Airlie House, Virginia, November 1997. J Clin Oncol 1999;17:3835-3849.
    • (1999) J Clin Oncol , vol.17 , pp. 3835-3849
    • Harris, N.L.1    Jaffe, E.S.2    Diebold, J.3    Flandrin, G.4    Muller-Hermelink, H.K.5    Vardiman, J.6    Lister, T.A.7    Bloomfield, C.D.8
  • 2
    • 0035123285 scopus 로고    scopus 로고
    • Leukaemia - A brief historical review from ancient times to 1950
    • Piller G: Leukaemia - a brief historical review from ancient times to 1950. Br J Haematol 2001;112:282-292.
    • (2001) Br J Haematol , vol.112 , pp. 282-292
    • Piller, G.1
  • 3
    • 0037434853 scopus 로고    scopus 로고
    • Imatinib mesylate - The new gold standard for treatment of chronic myeloid leukemia
    • Peggs K, Mackinnon S: Imatinib mesylate - the new gold standard for treatment of chronic myeloid leukemia. N Engl J Med 2003;348:1048-1050.
    • (2003) N Engl J Med , vol.348 , pp. 1048-1050
    • Peggs, K.1    Mackinnon, S.2
  • 4
    • 0037392444 scopus 로고    scopus 로고
    • Issues and progress with protein kinase inhibitors for cancer treatment
    • Dancey J, Sausville EA: Issues and progress with protein kinase inhibitors for cancer treatment. Nat Rev Drug Discov 2003;2:296-313.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 296-313
    • Dancey, J.1    Sausville, E.A.2
  • 5
    • 1342332310 scopus 로고    scopus 로고
    • Targeting protein kinase C-alpha (PKC-alpha) in cancer with the phosphorothioate antisense oligonucleotide aprinocarsen
    • Lahn M, Sundell K, Moore S: Targeting protein kinase C-alpha (PKC-alpha) in cancer with the phosphorothioate antisense oligonucleotide aprinocarsen. Ann NY Acad Sci 2003;1002:263-270.
    • (2003) Ann NY Acad Sci , vol.1002 , pp. 263-270
    • Lahn, M.1    Sundell, K.2    Moore, S.3
  • 6
    • 0033814862 scopus 로고    scopus 로고
    • Antisense approaches for the treatment of cancer
    • Monia BP, Holmlund J, Dorr FA: Antisense approaches for the treatment of cancer. Cancer Invest 2000;18:635-650.
    • (2000) Cancer Invest , vol.18 , pp. 635-650
    • Monia, B.P.1    Holmlund, J.2    Dorr, F.A.3
  • 7
    • 18644364558 scopus 로고    scopus 로고
    • Cancer Drugs. Smart weapons prove tough to design
    • Couzin J: Cancer Drugs. Smart weapons prove tough to design. Science 2002;298:522-525.
    • (2002) Science , vol.298 , pp. 522-525
    • Couzin, J.1
  • 8
    • 0027435064 scopus 로고
    • The potential of protein kinase C as a target for anticancer treatment
    • Basu A: The potential of protein kinase C as a target for anticancer treatment. Pharmacol Ther 1993;59:257-280.
    • (1993) Pharmacol Ther , vol.59 , pp. 257-280
    • Basu, A.1
  • 9
    • 0030987070 scopus 로고    scopus 로고
    • Regulation of protein kinase C
    • Newton AC: Regulation of protein kinase C. Curr Opin Cell Biol 1997;9:161-167.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 161-167
    • Newton, A.C.1
  • 10
    • 0023764824 scopus 로고
    • The molecular heterogeneity of protein kinase C and its implications for cellular regulation
    • Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988;334:661-665.
    • (1988) Nature , vol.334 , pp. 661-665
    • Nishizuka, Y.1
  • 12
    • 0028670129 scopus 로고
    • Regulation of protein kinase C and role in cancer biology
    • Blobe GC, Obeid LM, Hannun YA: Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev 1994;13:411-431.
    • (1994) Cancer Metastasis Rev , vol.13 , pp. 411-431
    • Blobe, G.C.1    Obeid, L.M.2    Hannun, Y.A.3
  • 14
    • 0031827507 scopus 로고    scopus 로고
    • Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer
    • Denham DW, Franz MG, Denham W, Zervos EE, Gower WR Jr, Rosemurgy AS, Norman J: Directed antisense therapy confirms the role of protein kinase C-alpha in the tumorigenicity of pancreatic cancer. Surgery 1998;124:218-223; discussion 223-224.
    • (1998) Surgery , vol.124 , pp. 218-223
    • Denham, D.W.1    Franz, M.G.2    Denham, W.3    Zervos, E.E.4    Gower Jr., W.R.5    Rosemurgy, A.S.6    Norman, J.7
  • 15
    • 0026667162 scopus 로고
    • Towards selective pharmacological modulation of protein kinase C - Opportunities for the development of novel antineoplastic agents
    • Gescher A: Towards selective pharmacological modulation of protein kinase C - opportunities for the development of novel antineoplastic agents. Br J Cancer 1992;66:10-19.
    • (1992) Br J Cancer , vol.66 , pp. 10-19
    • Gescher, A.1
  • 17
    • 0031427095 scopus 로고    scopus 로고
    • Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat
    • La Porta CA, Tessitore L, Comolli R: Changes in protein kinase C alpha, delta and in nuclear beta isoform expression in tumour and lung metastatic nodules induced by diethylnitrosamine in the rat. Carcinogenesis 1997;18:715-719.
    • (1997) Carcinogenesis , vol.18 , pp. 715-719
    • La Porta, C.A.1    Tessitore, L.2    Comolli, R.3
  • 18
    • 0024323584 scopus 로고
    • Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
    • O'Brian C, Vogel VG, Singletary SE, Ward NE: Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 1989;49:3215-3217.
    • (1989) Cancer Res , vol.49 , pp. 3215-3217
    • O'Brian, C.1    Vogel, V.G.2    Singletary, S.E.3    Ward, N.E.4
  • 19
    • 0006055537 scopus 로고
    • Protein kinase C inhibitors
    • Kuo J (ed): New York, Oxford University Press
    • O'Brian C, Kuo J: Protein kinase C inhibitors; in Kuo J (ed): Protein Kinase C. New York, Oxford University Press, 1994, pp 96-120.
    • (1994) Protein Kinase C , pp. 96-120
    • O'Brian, C.1    Kuo, J.2
  • 20
    • 0033019842 scopus 로고    scopus 로고
    • Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Cα antisense oligonucleotide
    • Shen L, Dean NM, Glazer RI: Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Cα antisense oligonucleotide. Mol Pharmacol 1999;55:396-402.
    • (1999) Mol Pharmacol , vol.55 , pp. 396-402
    • Shen, L.1    Dean, N.M.2    Glazer, R.I.3
  • 21
    • 0033542806 scopus 로고    scopus 로고
    • Antisense inhibition of protein kinase Cα reverses the transformed phenotype in human lung carcinoma cells
    • Wang XY, Repasky E, Liu HT: Antisense inhibition of protein kinase Cα reverses the transformed phenotype in human lung carcinoma cells. Exp Cell Res 1999;250:253-263.
    • (1999) Exp Cell Res , vol.250 , pp. 253-263
    • Wang, X.Y.1    Repasky, E.2    Liu, H.T.3
  • 22
    • 0027092794 scopus 로고
    • Role of protein kinase C in the modulation of multidrug resistance: Expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin
    • Ahmad S, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Glazer RI: Role of protein kinase C in the modulation of multidrug resistance: expression of the atypical gamma isoform of protein kinase C does not confer increased resistance to doxorubicin. Mol Pharmacol 1992;42:1004-1009.
    • (1992) Mol Pharmacol , vol.42 , pp. 1004-1009
    • Ahmad, S.1    Trepel, J.B.2    Ohno, S.3    Suzuki, K.4    Tsuruo, T.5    Glazer, R.I.6
  • 23
    • 0034818582 scopus 로고    scopus 로고
    • Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta
    • Gill PK, Gescher A, Gant TW: Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. Eur J Biochem 2001;268:4151-4157.
    • (2001) Eur J Biochem , vol.268 , pp. 4151-4157
    • Gill, P.K.1    Gescher, A.2    Gant, T.W.3
  • 24
    • 0028106219 scopus 로고
    • Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells
    • Gravitt KR, Ward NE, Fan D, Skibber JM, Levin B, O'Brian CA: Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. Biochem Pharmacol 1994;48:375-381.
    • (1994) Biochem Pharmacol , vol.48 , pp. 375-381
    • Gravitt, K.R.1    Ward, N.E.2    Fan, D.3    Skibber, J.M.4    Levin, B.5    O'Brian, C.A.6
  • 25
    • 0030027552 scopus 로고    scopus 로고
    • Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide
    • Gupta KP, Ward NE, Gravitt KR, Bergman PJ, O'Brian CA: Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide. J Biol Chem 1996;271: 2102-2111.
    • (1996) J Biol Chem , vol.271 , pp. 2102-2111
    • Gupta, K.P.1    Ward, N.E.2    Gravitt, K.R.3    Bergman, P.J.4    O'Brian, C.A.5
  • 28
    • 1442347508 scopus 로고    scopus 로고
    • Atlanta, American Cancer Society
    • Society AC: Cancer Facts and Figures: 2004. Atlanta, American Cancer Society, 2004.
    • (2004) Cancer Facts and Figures: 2004
  • 29
    • 0001656646 scopus 로고    scopus 로고
    • Malignancies of lymphoid cells
    • Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds): New York, McGraw-Hill
    • Freedman A, Nadler L: Malignancies of lymphoid cells; in Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds): Harrison's Principles of Internal Medicine. New York, McGraw-Hill, 1998, pp 695-712.
    • (1998) Harrison's Principles of Internal Medicine , pp. 695-712
    • Freedman, A.1    Nadler, L.2
  • 31
    • 0025319099 scopus 로고
    • Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: Associations with histology, clinical characteristics, and treatment outcome
    • The Nebraska Lymphoma Study Group
    • Schouten HC, Sanger WG, Weisenburger DD, Anderson J, Armitage JO: Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome. The Nebraska Lymphoma Study Group. Blood 1990;75:1841-1847.
    • (1990) Blood , vol.75 , pp. 1841-1847
    • Schouten, H.C.1    Sanger, W.G.2    Weisenburger, D.D.3    Anderson, J.4    Armitage, J.O.5
  • 33
    • 0026348839 scopus 로고
    • Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: Correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment
    • Offit K, Jhanwar SC, Ladanyi M, Filippa DA, Chaganti RS: Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: correlations between recurrent aberrations, histology, and exposure to cytotoxic treatment. Genes Chromosom Cancer 1991;3:189-201.
    • (1991) Genes Chromosom Cancer , vol.3 , pp. 189-201
    • Offit, K.1    Jhanwar, S.C.2    Ladanyi, M.3    Filippa, D.A.4    Chaganti, R.S.5
  • 34
    • 0029155014 scopus 로고
    • Chromosome 17 numerical abnormalities in 55 patients with non-Hodgkin's lymphoma: A fluorescence in situ hybridization study
    • Jendiroba D, Younes A, Katz R, Hill D, Cabanillas F, Andreeff M: Chromosome 17 numerical abnormalities in 55 patients with non-Hodgkin's lymphoma: a fluorescence in situ hybridization study. Leukemia 1995;9:1144-1146.
    • (1995) Leukemia , vol.9 , pp. 1144-1146
    • Jendiroba, D.1    Younes, A.2    Katz, R.3    Hill, D.4    Cabanillas, F.5    Andreeff, M.6
  • 35
    • 0031824382 scopus 로고    scopus 로고
    • Signal transduction via human leucocyte antigen class II molecules distinguishes between cord blood, normal, and malignant adult B lymphocytes
    • Garban F, Truman JP, Lord J, Drenou B, Plumas J, Jacob MC, Sotto JJ, Charron D, Mooney N: Signal transduction via human leucocyte antigen class II molecules distinguishes between cord blood, normal, and malignant adult B lymphocytes. Exp Hematol 1998;26:874-884.
    • (1998) Exp Hematol , vol.26 , pp. 874-884
    • Garban, F.1    Truman, J.P.2    Lord, J.3    Drenou, B.4    Plumas, J.5    Jacob, M.C.6    Sotto, J.J.7    Charron, D.8    Mooney, N.9
  • 36
    • 0035861580 scopus 로고    scopus 로고
    • Low levels of IFN-gamma down-regulate the integrin-dependent adhesion of B cells by activating a pathway that interferes with cytoskeleton rearrangement
    • Flaishon L, Lantner F, Hershkoviz R, Levo Y, Shachar I: Low levels of IFN-gamma down-regulate the integrin-dependent adhesion of B cells by activating a pathway that interferes with cytoskeleton rearrangement. J Biol Chem 2001;276:46701-46706.
    • (2001) J Biol Chem , vol.276 , pp. 46701-46706
    • Flaishon, L.1    Lantner, F.2    Hershkoviz, R.3    Levo, Y.4    Shachar, I.5
  • 37
    • 0032728995 scopus 로고    scopus 로고
    • Protein kinase C-alpha is essential for Ramos-BL B cell survival
    • Keenan C, Thompson S, Knox K, Pears C: Protein kinase C-alpha is essential for Ramos-BL B cell survival. Cell Immunol 1999;196:104-109.
    • (1999) Cell Immunol , vol.196 , pp. 104-109
    • Keenan, C.1    Thompson, S.2    Knox, K.3    Pears, C.4
  • 38
    • 0032528337 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Cα
    • Kelly ML, Tang Y, Rosensweig N, Clejan S, Beckman BS: Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Cα. Blood 1998;92:416-424.
    • (1998) Blood , vol.92 , pp. 416-424
    • Kelly, M.L.1    Tang, Y.2    Rosensweig, N.3    Clejan, S.4    Beckman, B.S.5
  • 39
    • 0031587955 scopus 로고    scopus 로고
    • The role of phorbol ester-sensitive protein kinase C isoforms in lymphokine-activated killer cell-mediated cytotoxicity: Dissociation between perforin-dependent and Fas-dependent cytotoxicity
    • Ohmi Y, Ohta A, Sasakura Y, Sato N, Yahata T, Santa K, Habu S, Nishimura T: The role of phorbol ester-sensitive protein kinase C isoforms in lymphokine-activated killer cell-mediated cytotoxicity: dissociation between perforin-dependent and Fas-dependent cytotoxicity. Biochem Biophys Res Commun 1997;235:461-464.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 461-464
    • Ohmi, Y.1    Ohta, A.2    Sasakura, Y.3    Sato, N.4    Yahata, T.5    Santa, K.6    Habu, S.7    Nishimura, T.8
  • 41
    • 18544377343 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- And phosphatidylinositol 3-kinase-dependent PKC alpha activation
    • Podar K, Tai YT, Lin BK, Narsimhan RP, Sattler M, Kijima T, Salgia R, Gupta D, Chauhan D, Anderson KC: Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation. J Biol Chem 2002;277:7875-7881.
    • (2002) J Biol Chem , vol.277 , pp. 7875-7881
    • Podar, K.1    Tai, Y.T.2    Lin, B.K.3    Narsimhan, R.P.4    Sattler, M.5    Kijima, T.6    Salgia, R.7    Gupta, D.8    Chauhan, D.9    Anderson, K.C.10
  • 45
    • 0021069856 scopus 로고
    • The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: A 12-year study (1970-1982)
    • Larson RA, Le Beau MM, Vardiman JW, Testa JR, Golomb HM, Rowley JD: The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia: a 12-year study (1970-1982). Cancer Genet Cytogenet 1983;10:219-236.
    • (1983) Cancer Genet Cytogenet , vol.10 , pp. 219-236
    • Larson, R.A.1    Le Beau, M.M.2    Vardiman, J.W.3    Testa, J.R.4    Golomb, H.M.5    Rowley, J.D.6
  • 46
    • 0030743148 scopus 로고    scopus 로고
    • Protein kinase C is not necessary for transforming growth factor beta-induced growth-arrest in leukemia cell lines
    • Manzel L, Macfarlane DE: Protein kinase C is not necessary for transforming growth factor beta-induced growth-arrest in leukemia cell lines. Leuk Res 1997;21:403-410.
    • (1997) Leuk Res , vol.21 , pp. 403-410
    • Manzel, L.1    Macfarlane, D.E.2
  • 47
    • 0026042176 scopus 로고
    • Expression of three major protein kinase C isozymes in various types of human leukemic cells
    • Komada F, Nishikawa M, Uemura Y, Morita K, Hidaka H, Shirakawa S: Expression of three major protein kinase C isozymes in various types of human leukemic cells. Cancer Res 1991;51:4271-4278.
    • (1991) Cancer Res , vol.51 , pp. 4271-4278
    • Komada, F.1    Nishikawa, M.2    Uemura, Y.3    Morita, K.4    Hidaka, H.5    Shirakawa, S.6
  • 49
    • 0026734540 scopus 로고
    • Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation
    • Devalia V, Thomas NS, Roberts PJ, Jones HM, Linch DC: Down-regulation of human protein kinase C alpha is associated with terminal neutrophil differentiation. Blood 1992;80:68-76.
    • (1992) Blood , vol.80 , pp. 68-76
    • Devalia, V.1    Thomas, N.S.2    Roberts, P.J.3    Jones, H.M.4    Linch, D.C.5
  • 50
    • 0031817961 scopus 로고    scopus 로고
    • Protein kinase C isoforms in normal and chronic myeloid leukemic neutrophils. Distinct signal for PKC alpha by immunodetection on PVDF membrane, decreased expression of PKC alpha and increased expression of PKC delta in leukemic neutrophils
    • Balasubramanian N, Advani SH, Zingde SM: Protein kinase C isoforms in normal and chronic myeloid leukemic neutrophils. Distinct signal for PKC alpha by immunodetection on PVDF membrane, decreased expression of PKC alpha and increased expression of PKC delta in leukemic neutrophils. Leuk Res 1998;22:597-604.
    • (1998) Leuk Res , vol.22 , pp. 597-604
    • Balasubramanian, N.1    Advani, S.H.2    Zingde, S.M.3
  • 51
    • 0033305290 scopus 로고    scopus 로고
    • Vitamin D analogs, 20-Epi-22-oxa-24a,26a,27a,-trihomo-1α,25(OH)2- vitamin D3, 1,24(OH)2-22-ene-24-cyclopropyl-vitamin D3 and 1α,25(OH)-2- lumisterol3 prime NB4 leukemia cells for monocytic differentiation via nongenomic signaling pathways, involving calcium and calpain
    • Berry DM, Meckling-Gill KA: Vitamin D analogs, 20-Epi-22-oxa-24a,26a,27a, -trihomo-1α,25(OH)2-vitamin D3, 1,24(OH)2-22-ene-24-cyclopropyl-vitamin D3 and 1α,25(OH)-2-lumisterol3 prime NB4 leukemia cells for monocytic differentiation via nongenomic signaling pathways, involving calcium and calpain. Endocrinology 1999;140:4779-4788.
    • (1999) Endocrinology , vol.140 , pp. 4779-4788
    • Berry, D.M.1    Meckling-Gill, K.A.2
  • 52
    • 0032584077 scopus 로고    scopus 로고
    • Changes of phospholipase D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells
    • Kang JH, Shin I, Han JS: Changes of phospholipase D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells. Exp Mol Med 1998;30:21-27.
    • (1998) Exp Mol Med , vol.30 , pp. 21-27
    • Kang, J.H.1    Shin, I.2    Han, J.S.3
  • 53
    • 0027064442 scopus 로고
    • Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha
    • Edashige K, Sato EF, Akimaru K, Kasai M, Utsumi K: Differentiation of HL-60 cells by phorbol ester is correlated with up-regulation of protein kinase C-alpha. Arch Biochem Biophys 1992;299:200-205.
    • (1992) Arch Biochem Biophys , vol.299 , pp. 200-205
    • Edashige, K.1    Sato, E.F.2    Akimaru, K.3    Kasai, M.4    Utsumi, K.5
  • 54
    • 0028971427 scopus 로고
    • Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA
    • Mallia CM, Jeter JR Jr, Fields AP, Wilson RB, Beckman BS: Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA. Mol Cell Biochem 1995;151:107-111.
    • (1995) Mol Cell Biochem , vol.151 , pp. 107-111
    • Mallia, C.M.1    Jeter Jr., J.R.2    Fields, A.P.3    Wilson, R.B.4    Beckman, B.S.5
  • 55
    • 31144448575 scopus 로고    scopus 로고
    • Phase II trial of the efficacy and safety of ISIS 3521/LY900003, an antisense inhibitor of PKC-alpha, in patients with low-grade, non-Hodgkin's lymphoma
    • abstract 1124
    • Emmanouilides C, Saleh A, Laufman L, Saven A, Harden E, Lister J: Phase II trial of the efficacy and safety of ISIS 3521/LY900003, an antisense inhibitor of PKC-alpha, in patients with low-grade, non-Hodgkin's lymphoma (abstract 1124). Proc ASCO 2002 Annu Meet.
    • Proc ASCO 2002 Annu Meet
    • Emmanouilides, C.1    Saleh, A.2    Laufman, L.3    Saven, A.4    Harden, E.5    Lister, J.6
  • 56
    • 0033566972 scopus 로고    scopus 로고
    • The pro-apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol production in the nucleus of HL-60 human promyelocytic leukemia cells
    • Martelli AM, Bortul R, Bareggi R, Tabellini G, Grill V, Baldini G, Narducci P: The pro-apoptotic drug camptothecin stimulates phospholipase D activity and diacylglycerol production in the nucleus of HL-60 human promyelocytic leukemia cells. Cancer Res 1999;59:3961-3967.
    • (1999) Cancer Res , vol.59 , pp. 3961-3967
    • Martelli, A.M.1    Bortul, R.2    Bareggi, R.3    Tabellini, G.4    Grill, V.5    Baldini, G.6    Narducci, P.7
  • 57
    • 0035876885 scopus 로고    scopus 로고
    • Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: Role of integrins
    • Breyer I, Azzi A: Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins. Free Radic Biol Med 2001;30:1381-1389.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1381-1389
    • Breyer, I.1    Azzi, A.2
  • 60
    • 0033805221 scopus 로고    scopus 로고
    • Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes
    • Kontny E, Kurowska M, Szczepanska K, Maslinski W: Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. J Leukoc Biol 2000;67:249-258.
    • (2000) J Leukoc Biol , vol.67 , pp. 249-258
    • Kontny, E.1    Kurowska, M.2    Szczepanska, K.3    Maslinski, W.4
  • 61
    • 0032484218 scopus 로고    scopus 로고
    • Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line
    • St-Denis A, Chano F, Tremblay P, St-Pierre Y, Descoteaux A: Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line. J Biol Chem 1998;273:32787-32792.
    • (1998) J Biol Chem , vol.273 , pp. 32787-32792
    • St-Denis, A.1    Chano, F.2    Tremblay, P.3    St-Pierre, Y.4    Descoteaux, A.5
  • 62
    • 0347627362 scopus 로고    scopus 로고
    • The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract
    • Lahn M, Paterson BM, Sundell K, Ma D: The role of protein kinase C-alpha (PKC-alpha) in malignancies of the gastrointestinal tract. Eur J Cancer 2004;40:10-20.
    • (2004) Eur J Cancer , vol.40 , pp. 10-20
    • Lahn, M.1    Paterson, B.M.2    Sundell, K.3    Ma, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.