Design and synthesis of bioisosteres of ultrapotent Protein Kinase C (PKC) ligand, 5-acetoxymethyl-5-hydroxymethyl-3-alkylidene tetrahydro-2-furanone

Archives of Pharmacal Research

Volumn 21, Issue 4, 1998, Pages 452-457

  Lee, Jeewoo ^a  

^a Seoul National University   (South Korea)

Author keywords

5,5 Disubstituted tetrahydro 2 furanone template; Bioisosteres; Diacylglycerol; Phorbol ester; Protein kinase C ligand

Indexed keywords

5 (ACETOXYMETHYL) 5 (HYDROXYMETHYL) 3 TETRADECYL 2,5 DIHYDRO 2 FURANONE; 5 (ACETOXYMETHYL) 5 (HYDROXYMETHYL) 3,3 DIHEXYLTETRAHYDRO 2 FURANONE; 5 (ACETOXYMETHYL) 5 (HYDROXYMETHYL) 3,3 DIOCTYLTETRAHYDRO 2 FURANONE; 5-(ACETOXYMETHYL)-5-(HYDROXYMETHYL)-3,3-DIHEXYLTETRAHYDRO-2-FURANONE; 5-(ACETOXYMETHYL)-5-(HYDROXYMETHYL)-3-TETRADECYL-2,5-DIHYDRO-2-FURANONE; 5-(ACETOXYMETHYL)-5--(HYDROXYMETHYL)-3,3-DIOCTYLTETRAHYDRO-2-FURANONE; DRUG DERIVATIVE; FURAN DERIVATIVE; GAMMA BUTYROLACTONE; LIGAND; PHORBOL DIBUTYRATE; PROTEIN KINASE C;

ARTICLE; CHEMISTRY; DRUG EFFECT; METABOLISM; MOLECULAR MIMICRY; PROTEIN BINDING; SYNTHESIS;

4-BUTYROLACTONE; FURANS; LIGANDS; MOLECULAR MIMICRY; PHORBOL 12,13-DIBUTYRATE; PROTEIN BINDING; PROTEIN KINASE C;

EID: 0032130269     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02974642     Document Type: Article

References (13)

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