Particulate delivery systems for vaccines: What can we expect?

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 6, 2006, Pages 717-728

  Bramwell, Vincent W ^a   Perrie, Yvonne ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; DENDRITIC CELL VACCINE; DICETYL PHOSPHATE; DNA POLYMERASE; DNA VACCINE; HEPATITIS A VACCINE; IMMUNOLIPOSOME; INFLEXAL; INFLUENZA VACCINE; LIPOSOME; MICROSPHERE; OVALBUMIN; POLYGLACTIN; POLYLACTIC ACID; POLYMER; RECOMBINANT ANTIGEN; RECOMBINANT VACCINE; RNA POLYMERASE; TOLL LIKE RECEPTOR; VACCINE; VIROSOME VACCINE;

ANTIGEN PRESENTING CELL; ARTICLE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOSTIMULATION; INNATE IMMUNITY; MUCOSAL IMMUNITY; NONHUMAN; PROTEIN PROTEIN INTERACTION; RECOMBINANT PLASMID; VACCINE PRODUCTION; VIRION; VIRUS PARTICLE;

ADJUVANTS, IMMUNOLOGIC; CHITOSAN; DRUG DELIVERY SYSTEMS; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; LIPOSOMES; POLYMERS; VACCINES;

EID: 33744791458     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.6.0002     Document Type: Article

References (93)

1. Ahmad-Nejad, P., Hacker, H., Rutz, M., Bauer, S., Vabulas, R. M., Wagner, H. (2002) Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32: 1958-1968
2. Allison, A. G., Gregoriadis, G. (1974) Liposomes as immunological adjuvants. Nature 252: 252
3. Alpar, H. O., Bramwell, V. W. (2002) Current status of DNA vaccines and their route of administration. Crit. Rev. Ther. Drug Carrier Syst. 19: 307-383
4. Alpar, H. O., Bowen, J. C., Brown, M. R. W. (1992) Effectiveness of liposomes as adjuvants of orally and nasally administered tetanus toxoid. Int. J. Pharm. 88: 335-344
5. Alpar, H. O., Eyles, J. E., Williamson, E. D., Somavarapu, S. (2001) Intranasal vaccination against plague, tetanus and diphtheria. Adv. Drug Deliv. Rev. 51: 173-201
6. Andersen, P. (1994) Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect. Immun. 62: 2536-2544
7. Aramaki, Y., Takano, S., Tsuchiya, S. (2001) Cationic liposomes induce macrophage apoptosis through mitochondrial pathway. Arch. Biochem. Biophys. 392: 245-250
8. Arigita, C., Bevaart, L., Everse, L. A., Koning, G. A., Hennink, W. E., Crommelin, D. J. A., van de Winkel, J. G. J., van Vugt, M. J., Kersten, G. F. A., Jiskoot, W. (2003) Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response. Infect. Immun. 71: 5210-5218
9. Arigita, C., Luijkx, T., Jiskoot, W., Poelen, M., Hennink, W. E., Crommelin, D. J. A., Ley, P. v. d., Els, C. v., Kersten, G. F. A. (2005) Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives. Vaccine 23: 5091-5098
10. Aussel, C., Pelassy, C., Bernard, A. (1995) Oleylamine and stearylamine increase phosphatidylserine synthesis in T cells by synergy with calcium ions. Int. J. Biochem. CellBiol. 27: 597-602
11. Azmin, M. N., Florence, A. T., Handjani-Vila, R. M., Stuart, J. F., Vanlerberghe, G., Whittaker, J. S. (1985) The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. J. Pharm. Pharmacol. 37: 237-242
12. Bochkov, V. N., Kadi, A., Huber, J., Gruber, F., Binder, B. R., Leitinger, N. (2002) Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature 419: 77-81
13. Bramwell, V. W., Perrie, Y. (2005a) Particulate delivery systems for vaccines. Crit. Rev. Ther. Drug Carrier Syst. 22: 151-214
14. Bramwell, V. W., Perrie, Y. (2005b) The rational design of vaccines. Drug Discov. Today 10: 1527-1534
15. Brewer, J. M., Alexander, J. (1992) The adjuvant activity of non-ionic surfactant vesicles (niosomes) on the BALB/c humoral response to bovine serum albumin. Immunology 75: 570-575
16. Brunei, F., Darbouret, A., Ronco, J. (1999) Cationic lipid DC-Chol induces an improved and balanced immunity able to overcome the unresponsiveness to the hepatitis B vaccine. Vaccine 17: 2192-2203
17. Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., Coutant, F., Metivier, D., Pichard, E., Aucouturier, P., Pierron, G., Garrido, C., Zitvogel, L., Kroemer, G. (2005) Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J. Exp. Med. 202: 1691-1701
18. Chatfield, S. N., Charles, I. G., Makoff, A. J., Oxer, M. D., Dougan, G., Pickard, D., Slater, D., Fairweather, N. F. (1992) Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology (N Y) 10: 888-892
19. Clements, J. D., Lyon, F. L., Lowe, K. L., Farrand, A. L., el-Morshidy, S. (1986) Oral immunization of mice with attenuated Salmonella enteritidis containing a recombinant plasmid which codes for production of the B subunit of heat-labile Escherichia coli enterotoxin. Infect. Immun. 53: 685-692
20. Cohen, J. (2005) Public health. High hopes and dilemmas for a cervical cancer vaccine. Science 308: 618-621
21. Coombes, A. G., Major, D., Wood, J. M., Hockley, D. J., Minor, P. D., Davis, S. S. (1998) Resorbable lamellar particles of polylactide as adjuvants for influenza virus vaccines. Biomaterials 19: 1073-1081
22. Cui, Z., Huang, L. (2005) Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer. Cancer Immunol. Immunother. 54: 1180-1190
23. Daemen, T., de Mare, A., Bungener, L., de Jonge, J., Huckriede, A., Wilschut, J. (2005) Virosomes for antigen and DNA delivery. Adv. Drug Deliv. Rev. 57: 451-463
24. Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E. M., Andersen, P. (2005) Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6′-dibehenate) - a novel adjuvant inducing both strong CMI and antibody responses. Biochim. Biophys. Acta 1718: 22-31
25. Dunne, A., O'Neill, L. A. J. (2005) Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett. 579: 3330-3335
26. Elvin, S. J., Eyles, J. E., Howard, K. A., Ravichandran, E., Somavarapu, S., Alpar, H. O., Williamson, E. D. (2006) Protection against bubonic and pneumonic plague with a single dose microencapsulated sub-unit vaccine. Vaccine in press
27. Eyles, J. E., Bramwell, V. W., Williamson, E. D., Alpar, H. O. (2001) Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 19: 4732-4742
28. Eyles, J. E., Carpenter, Z. C., Alpar, H. O., Williamson, E. D. (2003a) Immunological aspects of polymer microsphere vaccine delivery systems. J. Drug Target. 11: 509-514
29. Eyles, J. E., Bramwell, V. W., Singh, J., Williamson, E. D., Alpar, H. O. (2003b) Stimulation of spleen cells in vitro by nanospheric particles containing antigen. J. Control. Release 86: 25-32
30. Fairweather, N. F., Chatfield, S. N., Makoff, A. J., Strugnell, R. A., Bester, J., Maskell, D. J., Dougan, G. (1990) Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier. Infect. Immun. 58: 1323-1326
31. Farhood, H., Bottega, R., Epand, R. M., Huang, L. (1992) Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity. Biochim. Biophys. Acta 1111: 239-246
32. Fearon, K., Marshall, J. D., Abbate, C., Subramanian, S., Yee, P., Gregorio, J., Teshima, G., Ott, G., Tuck, S., Van, N. G., Coffman, R. L. (2003) A minimal human immunostimulatory CpG motif that potently induces IFN-7 and IFN-α production. Eur. J. Immunol. 33: 2114-2122
33. Felnerova, D., Viret, J. F., Gluck, R., Moser, C. (2004) Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 15: 518-529
34. Filion, M. C., Phillips, N. C. (1997) Anti-inflammatory activity of cationic lipids. Br. J. Pharmacol. 122: 551-557
35. Fisher, K. D., Stallwood, Y., Green, N. K., Ulbrich, K., Mautner, V., Seymour, L. W. (2001) Polymer-coated adenovirus permits efficient retargeting and evades-neutralising antibodies. Gene Ther. 8: 341-348
36. Foged, C., Arigita, C., Sundblad, A., Jiskoot, W., Storm, G., Frokjaer, S. (2004) Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition. Vaccine 22: 1903-1913
37. Friede, M., Aguado, M. T. (2005) Need for new vaccine formulations and potential of particulate antigen and DNA delivery systems. Adv. Drug Deliv. Rev. 57: 325-331
38. Gander, B. (2005) Trends in particulate antigen and DNA delivery systems for vaccines. Adv. Drug Deliv. Rev. 57: 321-323
39. Gregoriadis, G., McCormack, B., Obrenovic, M., Saffie, R., Zadi, B., Perrie, Y. (1999) Vaccine entrapment in liposomes. Methods 19: 156-162
40. Griffin, K. F., Eyles, J. E., Spiers, I. D., Alpar, H. O., Williamson, E. D. (2002) Protection against plague following immunisation with microencapsulated V antigen is reduced by co-encapsulation with IFN-γ or IL-4, but not IL-6. Vaccine 20: 3650-3657
41. Gutcher, I., Webb, P. R., Anderson, N. G. (2003) The isoform-specific regulation of apoptosis by protein kinase C. Cell Mol. Life Sci. 60: 1061-1070
42. Hasegawa, A., Fu, Y., Koyama, K. (2002) Nasal immunization with diphtheria toxoid conjugated-CD52 core peptide induced specific antibody production in genital tract of female mice. Am. J. Reprod. Immunol. 48: 305-311
43. Hoffmann, P. R., Kench, J. A., Vondracek, A., Kruk, E., Daleke, D. L., Jordan, M., Marrack, P., Henson, P. M., Fadok, V. A. (2005) Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J. Immunol. 174: 1393-1404
44. Huang, F., Subbaiah, P. V., Holian, O., Zhang, J., Johnson, A., Gertzberg, N., Lum, H. (2005) Lysophosphatidylcholine increases endothelial permeability: role of PKC-α and RhoA cross talk. Am. J. Physiol. Lung Cell Mol. Physiol. 289: L176-L185
45. Hung, W. C., Chang, H. C., Chuang, L. Y. (1999) Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. Biochem. J. 338: 161-166
46. Jiang, W., Gupta, R. K., Deshpande, M. C., Schwendeman, S. P. (2005) Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliv. Rev. 57: 391-410
47. Kang, P. B., Azad, A. K., Torrelles, J. B., Kaufman, T. M., Beharka, A., Tibesar, E., DesJardin, L. E., Schlesinger, L. S. (2005) The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202: 987-999
48. Katare, Y. K., Muthukumaran, T., Panda, A. K. (2005) Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles. Int. J. Pharm. 301: 149-160
49. Kelly, D., Conway, S. (2005) Bacterial modulation of mucosal innate immunity. Mol. Immunol. 42: 895-901
50. Kern, H., Volk, T., Knauer-Schiefer, S., Mieth, T., Rustow, B., Kox, W. J., Schlame, M. (1998) Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group. Biochim. Biophys. Acta 1394: 33-42
51. Ludewig, B., Barchiesi, F., Pericin, M., Zinkernagel, R. M., Hengartner, H., Schwendener, R. A. (2000) In vivo antigen loading and activation of dendritic cells via a liposomal peptide vaccine mediates protective antiviral and anti-tumour immunity. Vaccine 19: 23-32
52. Mazumdar, T., Anam, K., Ali, N. (2005) Influence of phospholipid composition on the adjuvanticity and protective efficacy of liposome- encapsulated Leishmania donovani antigens. J. Parasitol. 91: 269-274
53. McFadden, G. (2005) Poxvirus tropism. Nat. Rev. Microbiol. 3: 201-213
54. Mizuno, M., Yoshida, J. (1998) Improvement of transduction efficiency of recombinant adeno-associated virus vector by entrapment in multilamellar liposomes. Jpn J. Cancer Res. 89: 352-354
55. Mohammed, A. R., Coombes, A. G. A., Bramwell, V. W., Perrie, Y. Lyophilisation and sterilisation of liposomal vaccines to produce stabile and sterile products. Methods in press.
56. Morein, B., Sundquist, B., Hoglund, S., Dalsgaard, K., Osterhaus, A. (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308: 457-460
57. Moscat, J., az-Meco, M. T., Rennert, P. (2003) NF-κB activation by protein kinase C isoforms and B-cell function. EMBO Rep. 4: 31-36
58. Moschos, S. A., Bramwell, V. W., Somavarapu, S., Alpar, H. O. (2004) Adjuvant synergy: the effects of nasal coadministration of adjuvants. Immunol. Cell Biol. 82: 628-637
59. Mossman, S. P., Evans, L. S., Fang, H., Staas, J., Tice, T., Raychaudhuri, S., Grabstein, K. H., Cheever, M. A., Johnson, M. E. (2005) Development of a CTL vaccine for Her-2/neu using peptide-microspheres and adjuvants. Vaccine 23: 3545-3554
60. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., Lanzavecchia, A. (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6: 769-776
61. Park, J. W., Benz, C. C., Martin, F. J. (2004) Future directions of liposome- and immunoliposome-based cancer therapeutics. Semin. Oncol. 31(S): 196-205
62. Pearse, M. J., Drane, D. (2005) ISCOMATRIX® adjuvant for antigen delivery. Adv. Drug Deliv. Rev. 57: 465-474
63. Perrie, Y., Frederik, P. M., Gregoriadis, G. (2001) Liposome-mediated DNA vaccination: the effect of vesicle composition. Vaccine 19: 3301-3310
64. Perrie, Y., McNeil, S., Vangala, A. (2003) Liposome-mediated DNA immunisation via the subcutaneous route. J. Drug Target. 11: 555-563
65. Peyre, M., Fleck, R., Hockley, D., Gander, B., Sesardic, D. (2004) In vivo uptake of an experimental microencapsulated diphtheria vaccine following sub-cutaneous immunisation. Vaccine 22: 2430-2437
66. Richards, R. L., Rao, M., Vancott, T. C., Matyas, G. R., Birx, D. L., Alving, C. R. (2004) Liposome-stabilized oil-in-water emulsions as adjuvants: increased emulsion stability promotes induction of cytotoxic T lymphocytes against an HIV envelope antigen. Immunol. Cell Biol. 82: 531-538
67. Rim Seong, Y., Lee, C. H., Im, D. S. (1998) Characterization of the structural proteins of hepatitis C virus expressed by an adenovirus recombinant. Virus Res. 55: 177-185
68. Rose, R. C., Bonnez, W., Reichman, R. C., Garcea, R. L. (1993) Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles. J. Virol. 67: 1936-1944
69. Rosenkrands, I., Agger, E. M., Olsen, A. W., Korsholm, K. S., Andersen, C. S., Jensen, K. T., Andersen, P. (2005) Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system. Infect. Immun. 73: 5817-5826
70. Roth, A., Rohrbach, F., Weth, R., Frisch, B., Schuber, F., Wels, W. S. (2005) Induction of effective and antigen-specific antitumour immunity by a liposomal ErbB2/HER2 peptide-based vaccination construct. Br. J. Cancer 92: 1421-1429
71. Sadeghi, H., Hitt, M. M. (2005) Transcriptionally targeted adenovirus vectors. Curr. Gene Ther. 5: 411-427
72. Sando, J. J., Chertihin, O. I. (1996) Activation of protein kinase C by lysophosphatidic acid: dependence on composition of phospholipid vesicles. Biochem. J. 317: 583-588
73. Santosuosso, M., McCormick, S., Xing, Z. (2005) Adenoviral vectors for mucosal vaccination against infectious diseases. Viral Immunol. 18: 283-291
74. Singh, M., Briones, M., O'Hagan, D. T. (2001) A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J. Control. Release 70: 267-276
75. Singh, M., Kazzaz, J., Chesko, J., Soenawan, E., Ugozzoli, M., Giuliani, M., Pizza, M., Rappouli, R., O'Hagan, D. T. (2004) Anionic microparticles are a potent delivery system for recombinant antigens from Neisseria meningitidis serotype B. J. Pharm. Sci. 93: 273-282
76. Singh, J., Pandit, S., Bramwell, V. W., Alpar, H. O. (2006) Diphtheria toxoid loaded poly-(epsilon-caprolactone) nano-particles as mucosal vaccine delivery systems. Methods 38: 96-105
77. Somavarapu, S., Pandit, S., Gradassi, G., Bandera, M., Ravichandran, E., Alpar, O. H. (2005) Effect of Vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles. Int. J. Pharm. 298: 344-347
78. Standley, S. M., Kwon, Y. J., Murthy, N., Kunisawa, J., Shastri, N., Guillaudeu, S. J., Lau, L., Frechet, J. M. (2004) Acid-degradable particles for protein-based vaccines: enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjug. Chem. 15: 1281-1288
79. Steel, J. C., Cavanagh, H. M. A., Burton, M. A., Dingwall, D. J., Kalle, W. H. J. (2005) Modification of liposomal concentration in liposome/adenoviral complexes allows significant protection of adenoviral vectors from neutralising antibody, in vitro. J. Virol. Methods 126: 31-36
80. Sun, H., Pollock, K. G. J., Brewer, J. M. (2003) Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 21: 849-855
81. Suzuki, Y., Wakita, D., Chamoto, K., Narita, Y., Tsuji, T., Takeshima, T., Gyobu, H., Kawarada, Y., Kondo, S., Akira, S., Katoh, H., Ikeda, H., Nishimura, T. (2004) Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. Cancer Res. 64: 8754-8760
82. Toda, S., Ishii, N., Okada, E., Kusaakabe, K. I., Arai, H., Hamajima, K., Gorai, I., Nishioka, K., Okuda, K. (1997) HIV-1-specific cell-mediated immune responses induced by DNA vaccination were enhanced by mannan-coated liposomes and inhibited by anti-interferon-gamma antibody. Immunology 92: 111-117
83. Toonen, P. A., Crommelin, D. J. (1983) Immunoglobulins as targeting agents for liposome encapsulated drugs. Pharm. Weekbl. Sci. 16: 269-280
84. Uehara, A., Sugawara, Y., Kurata, S., Fujimoto, Y., Fukase, K., Kusumoto, S., Satta, Y., Sasano, T., Sugawara, S., Takada, H. (2005) Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Cell Microbiol. 7: 675-686
85. van der Ley, P., Steeghs, L., Hamstra, H. J., ten Hove, J., Zomer, B., van Alphen, L. (2001) Modification of lipid A biosynthesis in Neisseria meningitidis 1pxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity. Infect. Immun. 69: 5981-5990
86. van Heel, D. A., Ghosh, S., Butler, M., Hunt, K., Foxwell, B. M., Mengin-Lecreulx, D., Playford, R. J. (2005) Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur. J. Immunol. 35: 2471-2476
87. Waite, D. C., Jacobson, E. W., Ennis, F. A., Edelman, R., White, B., Kammer, R., Anderson, C., Kensil, C. R. (2001) Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21. Vaccine 19: 3957-3967
88. Watson, J. L., McKay, D. M. (2006) The immunophysiological impact of bacterial CpG DNA on the gut. Clin. Chim. Acta 364: 1-11
89. Westwood, A., Healey, G. D., Williamson, E. D., Eyles, J. E. (2005) Activation of dendritic cells by microparticles containing Bacillus anthracis protective antigen. Vaccine 23: 3857-3863
90. Westwood, A., Elvin, S. J., Healey, G. D., Williamson, E. D., Eyles, J. E. (2006) Immunological responses after immunisation of mice with microparticles containing antigen and single stranded RNA (polyuridylic acid). Vaccine 24: 1736-1743
91. Winau, F., Kaufmann, S. H., Schaible, U. E. (2004) Apoptosis paves the detour path for CDS T cell activation against intracellular bacteria. Cell Microbiol. 6: 599-607
92. Zhou, J., Sun, X. Y., Stenzel, D. J., Frazer, I. H. (1991) Expression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles. Virology 185: 251-257
93. Zinkernagel, R. M., Ehl, S., Aichele, P., Oehen, S., Kundig, T., Hengartner, H. (1997) Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol. Rev. 156: 199-209