Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

Gene Therapy

Volumn 8, Issue 5, 2001, Pages 341-348

  Fisher, K D ^a   Stallwood, Y ^a   Green, N K ^a   Ulbrich, K ^b   Mautner, V ^a   Seymour, L W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Adenovirus; Gene therapy; Polymer; Targeting

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; LIGAND; NEUTRALIZING ANTIBODY; POLY[N (2 HYDROXYPROPYL)METHACRYLAMIDE]; POLYMER; VASCULOTROPIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CANCER THERAPY; CELL CULTURE; CELL DIVISION; CELL TRANSPORT; CHEMICAL MODIFICATION; CONTROLLED STUDY; COXSACKIE VIRUS; DRUG DELIVERY SYSTEM; DRUG SELECTIVITY; DRUG TARGETING; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; HYDROPHILICITY; IMMUNE SYSTEM; IN VIVO STUDY; INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SAFETY; TARGET CELL; TECHNOLOGY; TISSUE DISTRIBUTION; VIROGENESIS; VIRUS NEUTRALIZATION; VIRUS RECOMBINANT; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; FEMALE; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HUMANS; LIGANDS; LUNG NEOPLASMS; METHACRYLATES; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; POLYMERS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; COXSACKIEVIRUS; DNA VIRUSES; HUMAN ADENOVIRUS TYPE 5;

EID: 0035077806     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301389     Document Type: Article

References (30)

1. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5
2. Immune responses to adenovirus and adeno-associated virus in humans
3. Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patients
4. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
5. Adenoviral vectors: Not to be sneezed at
6. Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli
7. Addition of a short peptide ligand to the adenovirus fiber protein
8. Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector
9. Targeted adenovirus gene-transfer to endothelial and smooth-muscle cells by using bispecific antibodies
10. Differential susceptibility of primary and established human glioma cells to adenovirus infection: Targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer
11. Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism: Evidence for reduced toxicity and enhanced antitumor activity in mice
12. Receptor-mediated targeted drug or toxin delivery
13. Phase I clinical and pharmacokinetic study of PK1 [N-(2- hydroxypropyl)methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents-drug-polymer conjugates
14. Decreased binding to proteins and cells of polymeric gene delivery vectors surface-modified with a multivalent hydrophilic polymer
15. A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
16. PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo
17. Modification of an adenoviral vector with biologically selected peptides: A novel strategy for gene delivery to cells of choice
18. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment
19. Stepwise dismantling of adenovirus 2 during entry into cells
20. The adenovirus protease is required for virus entry into host cells
21. The role of the nuclear pore complex in adenovirus DNA entry
22. Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro
23. Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways
24. Interaction of vasculotropin vascular endothelial-cell growth-factor with human umbilical vein endothelial-cells-binding, internalization, degradation and biological effects
25. A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells
26. Development of a rapid method for the PEGylation of adenovirus with enhanced transduction and improved stability under harsh storage conditions
27. Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro
28. Human adenovirus type 2 protein IIIA. Purification and characterisation
29. Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin - Immunogenicity, and effect on hematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral vitro
30. A fluorometric assay of the degree of modification of protein primary amines with polyethylene-glycol