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Volumn 301, Issue 1-2, 2005, Pages 149-160

Influence of particle size, antigen load, dose and additional adjuvant on the immune response from antigen loaded PLA microparticles

Author keywords

Antibody response; Antigen load; Particle size; PLA particles; Tetanus toxoid

Indexed keywords

ALUMINUM POTASSIUM SULFATE; POLYLACTIDE; TETANUS ANTIBODY; TETANUS TOXOID;

EID: 23944462440     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.05.028     Document Type: Article
Times cited : (118)

References (49)
  • 2
    • 8444243630 scopus 로고    scopus 로고
    • Vesicle size influences the trafficking, processing, and presentation of antigens in lipid vesicles
    • J.M. Brewer, K.G. Pollock, L. Tetley, and D.G. Russell Vesicle size influences the trafficking, processing, and presentation of antigens in lipid vesicles J. Immunol. 173 2004 6143 6150
    • (2004) J. Immunol. , vol.173 , pp. 6143-6150
    • Brewer, J.M.1    Pollock, K.G.2    Tetley, L.3    Russell, D.G.4
  • 3
    • 1842613560 scopus 로고    scopus 로고
    • Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles
    • A.M. Carcaboso, R.M. Hernandez, M. Igartua, J.E. Rosas, M.E. Patarroyo, and J.L. Pedraz Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles Vaccine 22 2004 1423 1432
    • (2004) Vaccine , vol.22 , pp. 1423-1432
    • Carcaboso, A.M.1    Hernandez, R.M.2    Igartua, M.3    Rosas, J.E.4    Patarroyo, M.E.5    Pedraz, J.L.6
  • 4
    • 1642498297 scopus 로고    scopus 로고
    • Enhancing immunogenicity and reducing dose of microparticulated synthetic vaccines: Single intradermal administration
    • A.M. Carcaboso, R.M. Hernandez, M. Igartua, J.E. Rosas, M.E. Patarroyo, and J.L. Pedraz Enhancing immunogenicity and reducing dose of microparticulated synthetic vaccines: single intradermal administration Pharm. Res. 21 2004 121 126
    • (2004) Pharm. Res. , vol.21 , pp. 121-126
    • Carcaboso, A.M.1    Hernandez, R.M.2    Igartua, M.3    Rosas, J.E.4    Patarroyo, M.E.5    Pedraz, J.L.6
  • 5
    • 0033038260 scopus 로고    scopus 로고
    • Single-administration vaccines: Controlled-release technology to mimic repeated immunizations
    • J.L. Cleland Single-administration vaccines: controlled-release technology to mimic repeated immunizations Trends Biotechnol. 17 1999 25 29
    • (1999) Trends Biotechnol. , vol.17 , pp. 25-29
    • Cleland, J.L.1
  • 6
    • 0030445728 scopus 로고    scopus 로고
    • Single dose, polymeric, microparticle-based vaccines: The influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen
    • A.G. Coombes, E.C. Lavelle, P.G. Jenkins, and S.S. Davis Single dose, polymeric, microparticle-based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen Vaccine 14 1996 1429 1438
    • (1996) Vaccine , vol.14 , pp. 1429-1438
    • Coombes, A.G.1    Lavelle, E.C.2    Jenkins, P.G.3    Davis, S.S.4
  • 7
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • M.P. Desai, V. Labhasetwar, G.L. Amidon, and R.J. Levy Gastrointestinal uptake of biodegradable microparticles: effect of particle size Pharm. Res. 13 1996 1838 1845
    • (1996) Pharm. Res. , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 8
    • 0035898931 scopus 로고    scopus 로고
    • Tetanus toxoid loaded preformed microsphere of cross-linked dextran
    • M. Diwan, R.K. Khar, and G.P. Talwar Tetanus toxoid loaded preformed microsphere of cross-linked dextran Vaccine 19 2001 3853 3859
    • (2001) Vaccine , vol.19 , pp. 3853-3859
    • Diwan, M.1    Khar, R.K.2    Talwar, G.P.3
  • 9
    • 0026636415 scopus 로고
    • Parameters affecting the immunogenicity of microencapsulated tetanus toxoid
    • I. Esparza, and T. Kissel Parameters affecting the immunogenicity of microencapsulated tetanus toxoid Vaccine 10 1992 714 720
    • (1992) Vaccine , vol.10 , pp. 714-720
    • Esparza, I.1    Kissel, T.2
  • 11
    • 0032490612 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) microparticles for the development of single dose controlled-release vaccines
    • R.K. Gupta, M. Singh, and D.T. O'Hagan Poly(lactide-co-glycolide) microparticles for the development of single dose controlled-release vaccines Adv. Drug Del. Rev. 32 1998 225 246
    • (1998) Adv. Drug Del. Rev. , vol.32 , pp. 225-246
    • Gupta, R.K.1    Singh, M.2    O'Hagan, D.T.3
  • 12
    • 0037157272 scopus 로고    scopus 로고
    • Influence of dose and immunization route on the serum IgG antibody response to BSA loaded PLGA microspheres
    • I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Influence of dose and immunization route on the serum IgG antibody response to BSA loaded PLGA microspheres Vaccine 20 2002 2181 2190
    • (2002) Vaccine , vol.20 , pp. 2181-2190
    • Gutierro, I.1    Hernandez, R.M.2    Igartua, M.3    Gascon, A.R.4    Pedraz, J.L.5
  • 13
    • 0037159628 scopus 로고    scopus 로고
    • Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres
    • I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres Vaccine 21 2002 67 77
    • (2002) Vaccine , vol.21 , pp. 67-77
    • Gutierro, I.1    Hernandez, R.M.2    Igartua, M.3    Gascon, A.R.4    Pedraz, J.L.5
  • 14
    • 0343632356 scopus 로고    scopus 로고
    • New advances in microsphere-based single dose vaccines
    • J. Hanes, J.L. Cleland, and R. Langer New advances in microsphere-based single dose vaccines Adv. Drug Del. Rev. 28 1997 97 119
    • (1997) Adv. Drug Del. Rev. , vol.28 , pp. 97-119
    • Hanes, J.1    Cleland, J.L.2    Langer, R.3
  • 15
    • 0033525798 scopus 로고    scopus 로고
    • Biodegradable microspheres containing influenza a vaccine: Immune response in mice
    • A.K. Hilbert, U. Fritzsche, and T. Kissel Biodegradable microspheres containing influenza A vaccine: immune response in mice Vaccine 17 1999 1065 1073
    • (1999) Vaccine , vol.17 , pp. 1065-1073
    • Hilbert, A.K.1    Fritzsche, U.2    Kissel, T.3
  • 16
    • 0036182057 scopus 로고    scopus 로고
    • Size-dependency of d,l-lactide/glycolide copolymer particulates for intraarticular delivery system on phagocytosis in rat synovium
    • E. Horisawa, K. Kubota, I. Tuboi, K. Sato, H. Yamamoto, H. Takeuchi, and Y. Kawashima Size-dependency of d,l-lactide/glycolide copolymer particulates for intraarticular delivery system on phagocytosis in rat synovium Pharm. Res. 19 2002 132 139
    • (2002) Pharm. Res. , vol.19 , pp. 132-139
    • Horisawa, E.1    Kubota, K.2    Tuboi, I.3    Sato, K.4    Yamamoto, H.5    Takeuchi, H.6    Kawashima, Y.7
  • 17
    • 0027234537 scopus 로고
    • The synovial response to intraarticular injection in rats of polyethylene wear particles
    • D.W. Howie, B. Menthey, S. Hay, and B.V. Roberts The synovial response to intraarticular injection in rats of polyethylene wear particles Clin. Orthop. 292 1993 352 357
    • (1993) Clin. Orthop. , vol.292 , pp. 352-357
    • Howie, D.W.1    Menthey, B.2    Hay, S.3    Roberts, B.V.4
  • 18
    • 0032484142 scopus 로고    scopus 로고
    • Enhanced immune response after subcutaneous and oral immunization with biodegradable PLGA microspheres
    • M. Igartua, R.M. Hernandez, A. Esquisabel, A.R. Gascon, M.B. Calvo, and J.L. Pedraz Enhanced immune response after subcutaneous and oral immunization with biodegradable PLGA microspheres J. Control. Rel. 56 1998 63 73
    • (1998) J. Control. Rel. , vol.56 , pp. 63-73
    • Igartua, M.1    Hernandez, R.M.2    Esquisabel, A.3    Gascon, A.R.4    Calvo, M.B.5    Pedraz, J.L.6
  • 19
    • 0034623966 scopus 로고    scopus 로고
    • Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres
    • P. Johansen, F. Estevez, R. Zurbriggen, H.P. Merkle, R. Gluck, G. Corradin, and B. Gander Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres Vaccine 19 2001 1047 1054
    • (2001) Vaccine , vol.19 , pp. 1047-1054
    • Johansen, P.1    Estevez, F.2    Zurbriggen, R.3    Merkle, H.P.4    Gluck, R.5    Corradin, G.6    Gander, B.7
  • 20
    • 0034194497 scopus 로고    scopus 로고
    • Ambiguities in the preclinical quality assessment of microparticulate vaccines
    • P. Johansen, B. Gander, H.P. Merkle, and D. Sesardic Ambiguities in the preclinical quality assessment of microparticulate vaccines Trends Biotechnol. 18 2000 203 211
    • (2000) Trends Biotechnol. , vol.18 , pp. 203-211
    • Johansen, P.1    Gander, B.2    Merkle, H.P.3    Sesardic, D.4
  • 21
    • 0642372760 scopus 로고    scopus 로고
    • Microencapsulation of vaccine antigens
    • D.H. Jones Microencapsulation of vaccine antigens Meth. Mol. Med. 87 2003 211 222
    • (2003) Meth. Mol. Med. , vol.87 , pp. 211-222
    • Jones, D.H.1
  • 22
    • 0011242009 scopus 로고    scopus 로고
    • Effect of alum on in vitro release profile and immunogenicity of microencapsulated tetanus toxoid
    • Y.K. Katare, and A.K. Panda Effect of alum on in vitro release profile and immunogenicity of microencapsulated tetanus toxoid Proc. Int. Symp. Control. Rel. Bioact. Mater. 28 2001 1059 1060
    • (2001) Proc. Int. Symp. Control. Rel. Bioact. Mater. , vol.28 , pp. 1059-1060
    • Katare, Y.K.1    Panda, A.K.2
  • 23
    • 0345167843 scopus 로고    scopus 로고
    • Potentiation of immune response from polymer entrapped antigen: Towards the development of single dose tetanus toxoid vaccine
    • Y.K. Katare, A.K. Panda, K. Lalwani, I.U. Haque, and M.M. Ali Potentiation of immune response from polymer entrapped antigen: towards the development of single dose tetanus toxoid vaccine Drug Del. 10 2003 231 238
    • (2003) Drug Del. , vol.10 , pp. 231-238
    • Katare, Y.K.1    Panda, A.K.2    Lalwani, K.3    Haque, I.U.4    Ali, M.M.5
  • 24
    • 0030475711 scopus 로고    scopus 로고
    • Single shot with tetanus toxoid in biodegradable polymer microsphere protects mice despite acid induced denaturation of the antigen
    • G.F.A. Kersten, D. Donders, A. Akkermans, and E.C. Beuveery Single shot with tetanus toxoid in biodegradable polymer microsphere protects mice despite acid induced denaturation of the antigen Vaccine 14 1996 1632 1672
    • (1996) Vaccine , vol.14 , pp. 1632-1672
    • Kersten, G.F.A.1    Donders, D.2    Akkermans, A.3    Beuveery, E.C.4
  • 25
    • 0019888281 scopus 로고
    • The stabilization of proteins by sucrose
    • J.C. Lee, and S.N. Timasheff The stabilization of proteins by sucrose J. Biol. Chem. 256 1981 7193 7201
    • (1981) J. Biol. Chem. , vol.256 , pp. 7193-7201
    • Lee, J.C.1    Timasheff, S.N.2
  • 26
    • 0030250862 scopus 로고    scopus 로고
    • Size effect on the antibody production induced by biodegradable microspheres containing antigen
    • R. Nakaoka, Y. Inoue, Y. Tabata, and Y. Ikada Size effect on the antibody production induced by biodegradable microspheres containing antigen Vaccine 14 1996 1251 1256
    • (1996) Vaccine , vol.14 , pp. 1251-1256
    • Nakaoka, R.1    Inoue, Y.2    Tabata, Y.3    Ikada, Y.4
  • 27
    • 0037024108 scopus 로고    scopus 로고
    • Uptake of poly(d,l-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo
    • K.D. Newman, P. Elamanchili, G.S. Kwon, and J. Samuel Uptake of poly(d,l-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo J. Biomed. Mater. Res. 60 2002 480 486
    • (2002) J. Biomed. Mater. Res. , vol.60 , pp. 480-486
    • Newman, K.D.1    Elamanchili, P.2    Kwon, G.S.3    Samuel, J.4
  • 28
    • 0027305289 scopus 로고
    • Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles
    • D.T. O'Hagan, H. Jeffery, and S.S. Davis Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles Vaccine 11 1993 965 969
    • (1993) Vaccine , vol.11 , pp. 965-969
    • O'Hagan, D.T.1    Jeffery, H.2    Davis, S.S.3
  • 29
    • 0036324712 scopus 로고    scopus 로고
    • Rapid endo-lysosomal escape of poly(d,l-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery
    • J. Panyam, W.Z. Zhou, S. Prabha, S.K. Sahoo, and V. Labhasetwar Rapid endo-lysosomal escape of poly(d,l-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery FASEB J. 16 2002 1217 1226
    • (2002) FASEB J. , vol.16 , pp. 1217-1226
    • Panyam, J.1    Zhou, W.Z.2    Prabha, S.3    Sahoo, S.K.4    Labhasetwar, V.5
  • 30
    • 0037331856 scopus 로고    scopus 로고
    • Dynamics of endocytosis and exocytosis of poly(d,l-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    • J. Panyam, and V. Labhasetwar Dynamics of endocytosis and exocytosis of poly(d,l-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells Pharm. Res. 20 2003 212 220
    • (2003) Pharm. Res. , vol.20 , pp. 212-220
    • Panyam, J.1    Labhasetwar, V.2
  • 31
    • 0037406546 scopus 로고    scopus 로고
    • An experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria
    • M. Peyre, D. Sesardic, H.P. Merkle, B. Gander, and P. Johansen An experimental divalent vaccine based on biodegradable microspheres induces protective immunity against tetanus and diphtheria J. Pharm. Sci. 92 2003 957 966
    • (2003) J. Pharm. Sci. , vol.92 , pp. 957-966
    • Peyre, M.1    Sesardic, D.2    Merkle, H.P.3    Gander, B.4    Johansen, P.5
  • 32
    • 4644280000 scopus 로고    scopus 로고
    • Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions
    • M. Peyre, R. Audran, F. Estevez, G. Corradin, B. Gander, D. Sesardic, and P. Johansen Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions J. Control. Rel. 99 2004 345 355
    • (2004) J. Control. Rel. , vol.99 , pp. 345-355
    • Peyre, M.1    Audran, R.2    Estevez, F.3    Corradin, G.4    Gander, B.5    Sesardic, D.6    Johansen, P.7
  • 33
    • 0031832926 scopus 로고    scopus 로고
    • Stabilization of dichloromethane-induced protein denaturation during microencapsulation
    • R.S. Raghuvanshi, S. Goyal, Om Singh, and A.K. Panda Stabilization of dichloromethane-induced protein denaturation during microencapsulation Pharm. Dev. Technol. 3 1998 269 276
    • (1998) Pharm. Dev. Technol. , vol.3 , pp. 269-276
    • Raghuvanshi, R.S.1    Goyal, S.2    Om, S.3    Panda, A.K.4
  • 34
    • 0034988662 scopus 로고    scopus 로고
    • Formulation and characterization of immunoreactive tetanus toxoid biodegradable polymer particles
    • R.S. Raghuvanshi, Om Singh, and A.K. Panda Formulation and characterization of immunoreactive tetanus toxoid biodegradable polymer particles Drug Del. 8 2001 99 106
    • (2001) Drug Del. , vol.8 , pp. 99-106
    • Raghuvanshi, R.S.1    Om, S.2    Panda, A.K.3
  • 35
    • 0036805063 scopus 로고    scopus 로고
    • Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants
    • R.S. Raghuvanshi, Y.K. Katare, K. Lalwani, M.M. Ali, O. Singh, and A.K. Panda Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants Int. J. Pharm. 245 2002 109 121
    • (2002) Int. J. Pharm. , vol.245 , pp. 109-121
    • Raghuvanshi, R.S.1    Katare, Y.K.2    Lalwani, K.3    Ali, M.M.4    Singh, O.5    Panda, A.K.6
  • 36
    • 0031737698 scopus 로고    scopus 로고
    • Fully mobilizing host defense: Building better vaccines
    • S. Raychaudhuri, and K.L. Rock Fully mobilizing host defense: building better vaccines Nat. Biotechnol. 16 1998 1025 1031
    • (1998) Nat. Biotechnol. , vol.16 , pp. 1025-1031
    • Raychaudhuri, S.1    Rock, K.L.2
  • 37
    • 0036000111 scopus 로고    scopus 로고
    • Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
    • S.P. Schwendeman Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems Crit. Rev. Ther. Drug Carrier Syst. 19 2002 73 98
    • (2002) Crit. Rev. Ther. Drug Carrier Syst. , vol.19 , pp. 73-98
    • Schwendeman, S.P.1
  • 38
    • 0036285313 scopus 로고    scopus 로고
    • Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres
    • L. Shi, M.J. Caulfield, R.T. Chern, R.A. Wilson, G. Sanyal, and D.B. Volkin Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres J. Pharm. Sci. 91 2002 1019 1035
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1019-1035
    • Shi, L.1    Caulfield, M.J.2    Chern, R.T.3    Wilson, R.A.4    Sanyal, G.5    Volkin, D.B.6
  • 39
    • 0030928864 scopus 로고    scopus 로고
    • Controlled release microparticles as a single dose hepatitis B vaccine: Evaluation of immunogenicity in mice
    • M. Singh, X.M. Li, J.P. McGee, T. Zamb, W. Koff, C.Y. Wang, and D.T. O'Hagan Controlled release microparticles as a single dose hepatitis B vaccine: evaluation of immunogenicity in mice Vaccine 15 1997 475 481
    • (1997) Vaccine , vol.15 , pp. 475-481
    • Singh, M.1    Li, X.M.2    McGee, J.P.3    Zamb, T.4    Koff, W.5    Wang, C.Y.6    O'Hagan, D.T.7
  • 40
    • 0030952306 scopus 로고    scopus 로고
    • Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single dose vaccine
    • M. Singh, X.M. Li, H. Wang, J.P. McGee, T. Zamb, W. Koff, C.Y. Wang, and D.T. O'Hagan Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single dose vaccine Infect. Immun. 65 1997 1716 1721
    • (1997) Infect. Immun. , vol.65 , pp. 1716-1721
    • Singh, M.1    Li, X.M.2    Wang, H.3    McGee, J.P.4    Zamb, T.5    Koff, W.6    Wang, C.Y.7    O'Hagan, D.T.8
  • 41
    • 0031861905 scopus 로고    scopus 로고
    • Long-lived plasma cells: A mechanism for maintaining persistent antibody production
    • M.K. Slifka, and R. Ahmed Long-lived plasma cells: a mechanism for maintaining persistent antibody production Curr. Opin. Immunol. 10 1998 252 258
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 252-258
    • Slifka, M.K.1    Ahmed, R.2
  • 42
    • 20144384536 scopus 로고    scopus 로고
    • Effect of additives on encapsulation efficiency, stability, and bioactivity of entrapped lysozyme from biodegradable polymer particles
    • C. Srinivasan, Y.K. Katare, T. Muthukumaran, and A.K. Panda Effect of additives on encapsulation efficiency, stability, and bioactivity of entrapped lysozyme from biodegradable polymer particles J. Microencapsul. 22 2005 127 138
    • (2005) J. Microencapsul. , vol.22 , pp. 127-138
    • Srinivasan, C.1    Katare, Y.K.2    Muthukumaran, T.3    Panda, A.K.4
  • 43
    • 0023748061 scopus 로고
    • Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage
    • Y. Tabata, and Y. Ikada Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage Biomaterials 9 1988 356 362
    • (1988) Biomaterials , vol.9 , pp. 356-362
    • Tabata, Y.1    Ikada, Y.2
  • 44
    • 0030470545 scopus 로고    scopus 로고
    • Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres
    • Y. Tabata, Y. Inoue, and Y. Ikada Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres Vaccine 14 1996 1677 1685
    • (1996) Vaccine , vol.14 , pp. 1677-1685
    • Tabata, Y.1    Inoue, Y.2    Ikada, Y.3
  • 45
    • 0035845725 scopus 로고    scopus 로고
    • Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?
    • L. Thiele, B. Rothen-Rutishauser, S. Jilek, H. Wunderli-Allenspach, H.P. Merkle, and E. Walter Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J. Control. Rel. 76 2001 59 71
    • (2001) J. Control. Rel. , vol.76 , pp. 59-71
    • Thiele, L.1    Rothen-Rutishauser, B.2    Jilek, S.3    Wunderli-Allenspach, H.4    Merkle, H.P.5    Walter, E.6
  • 46
    • 0028321707 scopus 로고
    • Dose and load studies for subcutaneous and oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin
    • T. Uchida, S. Martin, T.P. Foster, R.C. Wardley, and S. Grimm Dose and load studies for subcutaneous and oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin Pharm. Res. 11 1994 1009 1015
    • (1994) Pharm. Res. , vol.11 , pp. 1009-1015
    • Uchida, T.1    Martin, S.2    Foster, T.P.3    Wardley, R.C.4    Grimm, S.5
  • 47
    • 0028090433 scopus 로고
    • Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: Particle size study
    • T. Uchida, and S. Goto Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: particle size study Biol. Pharm. Bull. 17 1994 1272 1276
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 1272-1276
    • Uchida, T.1    Goto, S.2
  • 49
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • M. Weert van de, W.E. Hennink, and W. Jiskoot Protein instability in poly(lactic-co-glycolic acid) microparticles Pharm. Res. 17 2000 1159 1167
    • (2000) Pharm. Res. , vol.17 , pp. 1159-1167
    • Van De Weert, M.1    Hennink, W.E.2    Jiskoot, W.3


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