메뉴 건너뛰기




Volumn 11, Issue SUPPL. 1, 2006, Pages 2093-2105

Secreted WNT antagonists as tumor suppressors: Pro and con

Author keywords

Dickkopf; Review; sFRP; Tumor Suppressor; WIF 1; Wnt

Indexed keywords


EID: 33744722770     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1952     Document Type: Review
Times cited : (62)

References (113)
  • 1
    • 0037604557 scopus 로고    scopus 로고
    • A Wnt-Wnt situation
    • He, X.: A Wnt-Wnt situation. Dev Cell, 4, 791-7 (2003)
    • (2003) Dev Cell , vol.4 , pp. 791-797
    • He, X.1
  • 2
    • 13644269949 scopus 로고    scopus 로고
    • Wnt signalling and the mechanistic basis of tumour development
    • Ilyas, M.: Wnt signalling and the mechanistic basis of tumour development. J Pathol, 205, 130-44 (2005)
    • (2005) J Pathol , vol.205 , pp. 130-144
    • Ilyas, M.1
  • 3
    • 0038359353 scopus 로고    scopus 로고
    • Caught up in a Wnt storm: Wnt signaling in cancer
    • Giles, R. H., J. H. van Es & H. Clevers: Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta, 1653, 1-24 (2003)
    • (2003) Biochim Biophys Acta , vol.1653 , pp. 1-24
    • Giles, R.H.1    Van Es, J.H.2    Clevers, H.3
  • 5
    • 0037055583 scopus 로고    scopus 로고
    • Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
    • Reifenberger, J., C. B. Knobbe, M. Wolter, B. Blaschke, K. W. Schulte, T. Pietsch, T. Ruzicka & G. Reifenberger: Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. M J Cancer, 100, 549-56 (2002)
    • (2002) M J Cancer , vol.100 , pp. 549-556
    • Reifenberger, J.1    Knobbe, C.B.2    Wolter, M.3    Blaschke, B.4    Schulte, K.W.5    Pietsch, T.6    Ruzicka, T.7    Reifenberger, G.8
  • 11
    • 2442653144 scopus 로고    scopus 로고
    • Frizzled/WNT signalling: The insidious promoter of tumour growth and progression
    • Vincan, E.: Frizzled/WNT signalling: the insidious promoter of tumour growth and progression. Front Biosci, 9, 1023-34 (2004)
    • (2004) Front Biosci , vol.9 , pp. 1023-1034
    • Vincan, E.1
  • 12
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • Veeman, M. T., J. D. Axelrod & R. T. Moon: A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell, 5, 367-77 (2003)
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 13
    • 3843057846 scopus 로고    scopus 로고
    • The WNT/calcium pathway: Biochemical mediators, tools and future requirements
    • Kühl, M.: The WNT/calcium pathway: biochemical mediators, tools and future requirements. Front Biosci, 9, 967-74 (2004)
    • (2004) Front Biosci , vol.9 , pp. 967-974
    • Kühl, M.1
  • 14
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • Nateri, A. S., B. Spencer-Dene & A. Behrens: Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature, 437, 281-5 (2005)
    • (2005) Nature , vol.437 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 17
    • 0030905786 scopus 로고    scopus 로고
    • Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a
    • Olson, D. J., D. M. Gibo, G. Saggers, W. Debinski & R. Kumar: Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a. Cell Growth Differ, 8, 417-23 (1997)
    • (1997) Cell Growth Differ , vol.8 , pp. 417-423
    • Olson, D.J.1    Gibo, D.M.2    Saggers, G.3    Debinski, W.4    Kumar, R.5
  • 18
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson, M., J. Dejmek, P. O. Bendahl & T. Andersson: Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res, 62, 409-16 (2002)
    • (2002) Cancer Res , vol.62 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.O.3    Andersson, T.4
  • 20
    • 0034920494 scopus 로고    scopus 로고
    • Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling
    • Kühl, M., K. Geis, L. C. Sheldahl, T. Pukrop, R. T. Moon & D. Wedlich: Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling. Mech Dev, 106, 61-76 (2001)
    • (2001) Mech Dev , vol.106 , pp. 61-76
    • Kühl, M.1    Geis, K.2    Sheldahl, L.C.3    Pukrop, T.4    Moon, R.T.5    Wedlich, D.6
  • 22
    • 0043234811 scopus 로고    scopus 로고
    • Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    • Topol, L., X. Jiang, H. Choi, L. Garrett-Beal, P. J. Carolan & Y. Yang: Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol, 162, 899-908 (2003)
    • (2003) J Cell Biol , vol.162 , pp. 899-908
    • Topol, L.1    Jiang, X.2    Choi, H.3    Garrett-Beal, L.4    Carolan, P.J.5    Yang, Y.6
  • 24
    • 0030799081 scopus 로고    scopus 로고
    • The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling
    • Lin, K., S. Wang, M. A. Julius, J. Kitajewski, M. Moos, Jr. & F. P. Luyten: The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc Natl Acad Sci U S A, 94, 11196-200 (1997)
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11196-11200
    • Lin, K.1    Wang, S.2    Julius, M.A.3    Kitajewski, J.4    Moos Jr., M.5    Luyten, F.P.6
  • 25
    • 0036714307 scopus 로고    scopus 로고
    • Secreted Frizzled-related proteins: Searching for relationships and patterns
    • Jones, S. E. & C. Jomary: Secreted Frizzled-related proteins: searching for relationships and patterns. Bioessays, 24, 811-20 (2002)
    • (2002) Bioessays , vol.24 , pp. 811-820
    • Jones, S.E.1    Jomary, C.2
  • 26
    • 0037519264 scopus 로고    scopus 로고
    • The NTR module: Domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases
    • Bányai, L. & L. Patthy: The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases. Protein Sci, 8, 1636-42 (1999)
    • (1999) Protein Sci , vol.8 , pp. 1636-1642
    • Bányai, L.1    Patthy, L.2
  • 28
    • 0037085393 scopus 로고    scopus 로고
    • Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules
    • Chong, J. M., A. Üren, J. S. Rubin & D. W. Speicher: Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem, 277, 5134-44 (2002)
    • (2002) J Biol Chem , vol.277 , pp. 5134-5144
    • Chong, J.M.1    Üren, A.2    Rubin, J.S.3    Speicher, D.W.4
  • 29
    • 0032122460 scopus 로고    scopus 로고
    • Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
    • Leimeister, C., A. Bach & M. Gessler: Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Mech Dev, 75, 29-42 (1998)
    • (1998) Mech Dev , vol.75 , pp. 29-42
    • Leimeister, C.1    Bach, A.2    Gessler, M.3
  • 31
    • 4544377878 scopus 로고    scopus 로고
    • Wnt signaling went derailed again: A new track via the LIN-18 receptor?
    • He, X.: Wnt signaling went derailed again: a new track via the LIN-18 receptor? Cell, 118, 668-70 (2004)
    • (2004) Cell , vol.118 , pp. 668-670
    • He, X.1
  • 32
    • 13244257603 scopus 로고    scopus 로고
    • The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    • Gorfinkiel, N., J. Sierra, A. Callejo, C. Ibanez & I. Guerrero: The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev Cell, 8, 241-53 (2005)
    • (2005) Dev Cell , vol.8 , pp. 241-253
    • Gorfinkiel, N.1    Sierra, J.2    Callejo, A.3    Ibanez, C.4    Guerrero, I.5
  • 33
    • 13244292984 scopus 로고    scopus 로고
    • Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog
    • Glise, B., C. A. Miller, M. Crozatier, M. A. Halbisen, S. Wise, D. J. Olson, A. Vincent & S. S. Blair: Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell, 8, 255-66 (2005)
    • (2005) Dev Cell , vol.8 , pp. 255-266
    • Glise, B.1    Miller, C.A.2    Crozatier, M.3    Halbisen, M.A.4    Wise, S.5    Olson, D.J.6    Vincent, A.7    Blair, S.S.8
  • 35
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano, Y. & R. Kypta: Secreted antagonists of the Wnt signalling pathway. J Cell Sci, 116, 2627-34 (2003)
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 36
    • 0037386102 scopus 로고    scopus 로고
    • Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor
    • Bell, E., I. Munoz-Sanjuan, C. R. Altmann, A. Vonica & A. H. Brivanlou: Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. Development, 130, 1381-9 (2003)
    • (2003) Development , vol.130 , pp. 1381-1389
    • Bell, E.1    Munoz-Sanjuan, I.2    Altmann, C.R.3    Vonica, A.4    Brivanlou, A.H.5
  • 37
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao, B., W. Wu, Y. Li, D. Hoppe, P. Stannek, A. Glinka & C. Niehrs: LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature, 411, 321-5 (2001)
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 38
  • 39
    • 0034933057 scopus 로고    scopus 로고
    • Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
    • Bafico, A., G. Liu, A. Yaniv, A. Gazit & S. A. Aaronson: Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol, 3, 683-6 (2001)
    • (2001) Nat Cell Biol , vol.3 , pp. 683-686
    • Bafico, A.1    Liu, G.2    Yaniv, A.3    Gazit, A.4    Aaronson, S.A.5
  • 40
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka, A., W. Wu, H. Delius, A. P. Monaghan, C. Blumenstock & C. Niehrs: Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature, 391, 357-62 (1998)
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 42
    • 0036337388 scopus 로고    scopus 로고
    • Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins
    • Brott, B. K. & S. Y. Sokol: Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol, 22, 6100-10 (2002)
    • (2002) Mol Cell Biol , vol.22 , pp. 6100-6110
    • Brott, B.K.1    Sokol, S.Y.2
  • 43
    • 0037413696 scopus 로고    scopus 로고
    • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    • Mao, B. & C. Niehrs: Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene, 302, 179-83 (2003)
    • (2003) Gene , vol.302 , pp. 179-183
    • Mao, B.1    Niehrs, C.2
  • 44
    • 0141484619 scopus 로고    scopus 로고
    • Functional characterization of WNT7A signaling in PC12 cells: Interaction with a FZD5 × LRP6 receptor complex and modulation by Dickkopf proteins
    • Caricasole, A., T. Ferraro, L. Iacovelli, E. Barletta, A. Caruso, D. Melchiorri, G. C. Terstappen & F. Nicoletti: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 × LRP6 receptor complex and modulation by Dickkopf proteins. J Biol Chem, 278, 37024-31 (2003)
    • (2003) J Biol Chem , vol.278 , pp. 37024-37031
    • Caricasole, A.1    Ferraro, T.2    Iacovelli, L.3    Barletta, E.4    Caruso, A.5    Melchiorri, D.6    Terstappen, G.C.7    Nicoletti, F.8
  • 45
    • 9244240664 scopus 로고    scopus 로고
    • Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway
    • Hoang, B. H., T. Kubo, J. H. Healey, R. Yang, S. S. Nathan, E. A. KoIb, B. Mazza, P. A. Meyers & R. Gorlick: Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res, 64, 2734-9 (2004)
    • (2004) Cancer Res , vol.64 , pp. 2734-2739
    • Hoang, B.H.1    Kubo, T.2    Healey, J.H.3    Yang, R.4    Nathan, S.S.5    Koib, E.A.6    Mazza, B.7    Meyers, P.A.8    Gorlick, R.9
  • 47
    • 0034649592 scopus 로고    scopus 로고
    • Mutual antagonism between dickkopfl and dickkopG regulates Wnt/Beta-catenin signalling
    • Wu, W., A. Glinka, H. Delius & C. Niehrs: Mutual antagonism between dickkopfl and dickkopG regulates Wnt/Beta-catenin signalling. Curr Biol, 10, 1611-4 (2000)
    • (2000) Curr Biol , vol.10 , pp. 1611-1614
    • Wu, W.1    Glinka, A.2    Delius, H.3    Niehrs, C.4
  • 49
  • 50
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor
    • Semenov, M., K. Tamai & X. He: SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem, 280, 26770-5 (2005)
    • (2005) J Biol Chem , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 51
    • 0038267120 scopus 로고    scopus 로고
    • Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    • Kusu, N., J. Laurikkala, M. Imanishi, H. Usui, M. Konishi, A. Miyake, I. Thesleff & N. Itoh: Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem, 278, 24113-7 (2003)
    • (2003) J Biol Chem , vol.278 , pp. 24113-24117
    • Kusu, N.1    Laurikkala, J.2    Imanishi, M.3    Usui, H.4    Konishi, M.5    Miyake, A.6    Thesleff, I.7    Itoh, N.8
  • 52
    • 2542631834 scopus 로고    scopus 로고
    • Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex
    • Mercurio, S., B. Latinkic, N. Itasaki, R. Krumlauf & J. C. Smith: Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development, 131, 2137-47 (2004)
    • (2004) Development , vol.131 , pp. 2137-2147
    • Mercurio, S.1    Latinkic, B.2    Itasaki, N.3    Krumlauf, R.4    Smith, J.C.5
  • 53
    • 0033541389 scopus 로고    scopus 로고
    • The CCN family of angiogenic regulators: The integrin connection
    • Lau, L. F. & S. C. Lam: The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res, 248, 44-57 (1999)
    • (1999) Exp Cell Res , vol.248 , pp. 44-57
    • Lau, L.F.1    Lam, S.C.2
  • 54
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • Rhee, C. S., M. Sen, D. Lu, C. Wu, L. Leoni, J. Rubin, M. Corr & D. A. Carson: Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene, 21, 6598-605 (2002)
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.S.1    Sen, M.2    Lu, D.3    Wu, C.4    Leoni, L.5    Rubin, J.6    Corr, M.7    Carson, D.A.8
  • 55
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico, A., G. Liu, L. Goldin, V. Harris & S. A. Aaronson: An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell, 6, 497-506 (2004)
    • (2004) Cancer Cell , vol.6 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 59
    • 0030933978 scopus 로고    scopus 로고
    • Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
    • Leyns, L., T. Bouwmeester, S. H. Kim, S. Piccolo & E. M. De Robertis: Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell, 88, 747-56 (1997)
    • (1997) Cell , vol.88 , pp. 747-756
    • Leyns, L.1    Bouwmeester, T.2    Kim, S.H.3    Piccolo, S.4    De Robertis, E.M.5
  • 61
    • 0031870862 scopus 로고    scopus 로고
    • Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
    • Zhou, Z., J. Wang, X. Han, J. Zhou & S. Linder: Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. Int J Cancer, 78, 95-9 (1998)
    • (1998) Int J Cancer , vol.78 , pp. 95-99
    • Zhou, Z.1    Wang, J.2    Han, X.3    Zhou, J.4    Linder, S.5
  • 62
    • 0033545570 scopus 로고    scopus 로고
    • Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes
    • Ugolini, F., J. Adelaide, E. Charafe-Jauffret, C. Nguyen, J. Jacquemier, B. Jordan, D. Birnbaum & M. J. Pebusque: Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene, 18, 1903-10 (1999)
    • (1999) Oncogene , vol.18 , pp. 1903-1910
    • Ugolini, F.1    Adelaide, J.2    Charafe-Jauffret, E.3    Nguyen, C.4    Jacquemier, J.5    Jordan, B.6    Birnbaum, D.7    Pebusque, M.J.8
  • 66
    • 0035861791 scopus 로고    scopus 로고
    • Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer
    • To, K. F., M. W. Chan, W. K. Leung, J. Yu, J. H. Tong, T. L. Lee, F. K. Chan & J. J. Sung: Alterations of frizzled (FzE3) and secreted frizzled related protein (hsFRP) expression in gastric cancer. Life Sci, 70, 483-9 (2001)
    • (2001) Life Sci , vol.70 , pp. 483-489
    • To, K.F.1    Chan, M.W.2    Leung, W.K.3    Yu, J.4    Tong, J.H.5    Lee, T.L.6    Chan, F.K.7    Sung, J.J.8
  • 67
    • 0036429396 scopus 로고    scopus 로고
    • Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer
    • Ko, J., K. S. Ryu, Y. H. Lee, D. S. Na, Y. S. Kim, Y. M. Oh, I. S. Kim & J. W. Kim: Human secreted frizzled-related protein is down-regulated and induces apoptosis in human cervical cancer. Exp Cell Res, 280, 280-7 (2002)
    • (2002) Exp Cell Res , vol.280 , pp. 280-287
    • Ko, J.1    Ryu, K.S.2    Lee, Y.H.3    Na, D.S.4    Kim, Y.S.5    Oh, Y.M.6    Kim, I.S.7    Kim, J.W.8
  • 69
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman, J. G. & S. B. Baylin: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med, 349, 2042-54 (2003)
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 73
    • 30544447981 scopus 로고    scopus 로고
    • Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer
    • Fukui, T., M. Kondo, G. Ito, O. Maeda, N. Sato, H. Yoshioka, K. Yokoi, Y. Ueda, K. Shimokata & Y. Sekido: Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene, 24, 6323-7 (2005)
    • (2005) Oncogene , vol.24 , pp. 6323-6327
    • Fukui, T.1    Kondo, M.2    Ito, G.3    Maeda, O.4    Sato, N.5    Yoshioka, H.6    Yokoi, K.7    Ueda, Y.8    Shimokata, K.9    Sekido, Y.10
  • 74
    • 23244461593 scopus 로고    scopus 로고
    • Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus
    • Zou, H., J. R. Molina, J. J. Harrington, N. K. Osborn, K. K. Klatt, Y. Romero, L. J. Burgart & D. A. Ahlquist: Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Int J Cancer, 116, 584-91 (2005)
    • (2005) Int J Cancer , vol.116 , pp. 584-591
    • Zou, H.1    Molina, J.R.2    Harrington, J.J.3    Osborn, N.K.4    Klatt, K.K.5    Romero, Y.6    Burgart, L.J.7    Ahlquist, D.A.8
  • 75
    • 4444343396 scopus 로고    scopus 로고
    • Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma
    • Lee, A. Y., B. He, L. You, S. Dadfarmay, Z. Xu, J. Mazieres, I. Mikami, F. McCormick & D. M. Jablons: Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene, 23, 6672-6 (2004)
    • (2004) Oncogene , vol.23 , pp. 6672-6676
    • Lee, A.Y.1    He, B.2    You, L.3    Dadfarmay, S.4    Xu, Z.5    Mazieres, J.6    Mikami, I.7    McCormick, F.8    Jablons, D.M.9
  • 78
    • 0034732151 scopus 로고    scopus 로고
    • Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53
    • Wang, J., J. Shou & X. Chen: Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene, 19, 1843-8 (2000)
    • (2000) Oncogene , vol.19 , pp. 1843-1848
    • Wang, J.1    Shou, J.2    Chen, X.3
  • 79
    • 85047699343 scopus 로고    scopus 로고
    • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA
    • Shou, J., F. Ali-Osman, A. S. Multani, S. Pathak, P. Fedi & K. S. Srivenugopal: Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene, 21, 878-89 (2002)
    • (2002) Oncogene , vol.21 , pp. 878-889
    • Shou, J.1    Ali-Osman, F.2    Multani, A.S.3    Pathak, S.4    Fedi, P.5    Srivenugopal, K.S.6
  • 80
    • 0036500653 scopus 로고    scopus 로고
    • The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death
    • Grotewold, L. & U. Ruther: The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. Embo J, 21, 966-75 (2002)
    • (2002) Embo J , vol.21 , pp. 966-975
    • Grotewold, L.1    Ruther, U.2
  • 82
    • 1642545618 scopus 로고    scopus 로고
    • A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation
    • Mikheev, A. M., S. A. Mikheeva, B. Liu, P. Cohen & H. Zarbl: A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis, 25, 47-59 (2004)
    • (2004) Carcinogenesis , vol.25 , pp. 47-59
    • Mikheev, A.M.1    Mikheeva, S.A.2    Liu, B.3    Cohen, P.4    Zarbl, H.5
  • 84
    • 0034607050 scopus 로고    scopus 로고
    • A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines
    • Tsuji, T., M. Miyazaki, M. Sakaguchi, Y. Inoue & M. Namba: A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochem Biophys Res Commun, 268, 20-4 (2000)
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 20-24
    • Tsuji, T.1    Miyazaki, M.2    Sakaguchi, M.3    Inoue, Y.4    Namba, M.5
  • 88
    • 11244323971 scopus 로고    scopus 로고
    • Dickkopf-3/REIC functions as a suppressor gene of tumor growth
    • Hsieh, S. Y., P. S. Hsieh, C. T. Chiu & W. Y. Chen: Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene, 23, 9183-9 (2004)
    • (2004) Oncogene , vol.23 , pp. 9183-9189
    • Hsieh, S.Y.1    Hsieh, P.S.2    Chiu, C.T.3    Chen, W.Y.4
  • 89
    • 0034738968 scopus 로고    scopus 로고
    • Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells
    • Roth, W., C. Wild-Bode, M. Platten, C. Grimmel, H. S. Melkonyan, J. Dichgans & M. Weller: Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. Oncogene, 19, 4210-20 (2000)
    • (2000) Oncogene , vol.19 , pp. 4210-4220
    • Roth, W.1    Wild-Bode, C.2    Platten, M.3    Grimmel, C.4    Melkonyan, H.S.5    Dichgans, J.6    Weller, M.7
  • 90
    • 1642396958 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands
    • Lee, J. L., C. J. Chang, S. Y. Wu, D. R. Sargan & C. T. Lin: Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands. Breast Cancer Res Treat, 84, 139-49 (2004)
    • (2004) Breast Cancer Res Treat , vol.84 , pp. 139-149
    • Lee, J.L.1    Chang, C.J.2    Wu, S.Y.3    Sargan, D.R.4    Lin, C.T.5
  • 91
    • 2442597995 scopus 로고    scopus 로고
    • Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: A possible mechanism of mammary tumorigenesis
    • Lee, J. L., C. T. Lin, L. L. Chueh & C. J. Chang: Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis. J Biol Chem, 279, 14602-9 (2004)
    • (2004) J Biol Chem , vol.279 , pp. 14602-14609
    • Lee, J.L.1    Lin, C.T.2    Chueh, L.L.3    Chang, C.J.4
  • 92
    • 0036277973 scopus 로고    scopus 로고
    • Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity
    • Fukuhara, K., M. Kariya, M. Kita, H. Shime, T. Kanamori, C. Kosaka, A. Orii, J. Fujita & S. Fujii: Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity. J Clin Endocrinol Metab, 87, 1729-36 (2002)
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1729-1736
    • Fukuhara, K.1    Kariya, M.2    Kita, M.3    Shime, H.4    Kanamori, T.5    Kosaka, C.6    Orii, A.7    Fujita, J.8    Fujii, S.9
  • 93
    • 1642494703 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 1 (SFRPl) protects fibroblasts from ceramide-induced apoptosis
    • Han, X. & S. Amar: Secreted frizzled-related protein 1 (SFRPl) protects fibroblasts from ceramide-induced apoptosis. J Biol Chem, 279, 2832-40 (2004)
    • (2004) J Biol Chem , vol.279 , pp. 2832-2840
    • Han, X.1    Amar, S.2
  • 95
    • 0032948879 scopus 로고    scopus 로고
    • Differential expression of frpHE: A novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy
    • Abu-Jawdeh, G., N. Cornelia, Y. Tomita, L. F. Brown, K. Tognazzi, S. Y. Sokol & O. Kocher: Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab Invest, 79, 439-47 (1999)
    • (1999) Lab Invest , vol.79 , pp. 439-447
    • Abu-Jawdeh, G.1    Cornelia, N.2    Tomita, Y.3    Brown, L.F.4    Tognazzi, K.5    Sokol, S.Y.6    Kocher, O.7
  • 96
    • 0036154038 scopus 로고    scopus 로고
    • Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
    • Wong, S. C., S. F. Lo, K. C. Lee, J. W. Yam, J. K. Chan & W. L. Wendy Hsiao: Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J Pathol, 196, 145-53 (2002)
    • (2002) J Pathol , vol.196 , pp. 145-153
    • Wong, S.C.1    Lo, S.F.2    Lee, K.C.3    Yam, J.W.4    Chan, J.K.5    Wendy Hsiao, W.L.6
  • 99
    • 1442335374 scopus 로고    scopus 로고
    • Wnt inhibitory factor-1: A candidate for a new player in tumorigenesis of intestinal epithelial cells
    • Cebrat, M., L. Strzadala & P. Kisielow: Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cancer Lett, 206, 107-13 (2004)
    • (2004) Cancer Lett , vol.206 , pp. 107-113
    • Cebrat, M.1    Strzadala, L.2    Kisielow, P.3
  • 100
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian, E., F. Zhan, R. Walker, E. Rasmussen, Y. Ma, B. Barlogie & J. D. Shaughnessy, Jr.: The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med, 349, 2483-94 (2003)
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6    Shaughnessy Jr., J.D.7
  • 103
    • 0034710915 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
    • Playford, M. P., D. Bicknell, W. F. Bodmer & V. M. Macaulay: Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci U S A, 97, 12103-8 (2000)
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12103-12108
    • Playford, M.P.1    Bicknell, D.2    Bodmer, W.F.3    Macaulay, V.M.4
  • 104
    • 0035843148 scopus 로고    scopus 로고
    • Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    • Desbois-Mouthon, C., A. Cadoret, M. J. Blivet-Van Eggelpoel, F. Bertrand, G. Cherqui, C. Perret & J. Capeau: Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene, 20, 252-9 (2001)
    • (2001) Oncogene , vol.20 , pp. 252-259
    • Desbois-Mouthon, C.1    Cadoret, A.2    Blivet-Van Eggelpoel, M.J.3    Bertrand, F.4    Cherqui, G.5    Perret, C.6    Capeau, J.7
  • 105
    • 0035899466 scopus 로고    scopus 로고
    • IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition
    • Morali, O. G., V. Delmas, R. Moore, C. Jeanney, J. P. Thiery & L. Larue: IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene, 20, 4942-50 (2001)
    • (2001) Oncogene , vol.20 , pp. 4942-4950
    • Morali, O.G.1    Delmas, V.2    Moore, R.3    Jeanney, C.4    Thiery, J.P.5    Larue, L.6
  • 106
    • 0034908762 scopus 로고    scopus 로고
    • Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway
    • Danilkovitch-Miagkova, A., A. Miagkov, A. Skeel, N. Nakaigawa, B. Zbar & E. J. Leonard: Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol, 21, 5857-68 (2001)
    • (2001) Mol Cell Biol , vol.21 , pp. 5857-5868
    • Danilkovitch-Miagkova, A.1    Miagkov, A.2    Skeel, A.3    Nakaigawa, N.4    Zbar, B.5    Leonard, E.J.6
  • 107
    • 2542452082 scopus 로고    scopus 로고
    • Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells
    • Graham, N. A. & A. R. Asthagiri: Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells. J Biol Chem, 279, 23517-24 (2004)
    • (2004) J Biol Chem , vol.279 , pp. 23517-23524
    • Graham, N.A.1    Asthagiri, A.R.2
  • 108
    • 0035811492 scopus 로고    scopus 로고
    • Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    • Dann, C. E., J. C. Hsieh, A. Rattner, D. Sharma, J. Nathans & D. J. Leahy: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature, 412, 86-90 (2001)
    • (2001) Nature , vol.412 , pp. 86-90
    • Dann, C.E.1    Hsieh, J.C.2    Rattner, A.3    Sharma, D.4    Nathans, J.5    Leahy, D.J.6
  • 109
    • 0033523005 scopus 로고    scopus 로고
    • Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    • Bafico, A., A. Gazit, T. Pramila, P. W. Finch, A. Yaniv & S. A. Aaronson: Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem, 274, 16180-7 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 16180-16187
    • Bafico, A.1    Gazit, A.2    Pramila, T.3    Finch, P.W.4    Yaniv, A.5    Aaronson, S.A.6
  • 111
    • 0037039162 scopus 로고    scopus 로고
    • Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis
    • Lisovsky, M., K. Itoh & S. Y. Sokol: Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis. Curr Biol, 12, 53-8 (2002)
    • (2002) Curr Biol , vol.12 , pp. 53-58
    • Lisovsky, M.1    Itoh, K.2    Sokol, S.Y.3
  • 113
    • 0346458662 scopus 로고    scopus 로고
    • Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
    • Kuhnert, F., C. R. Davis, H. T. Wang, P. Chu, M. Lee, J. Yuan, R. Nusse & C. J. Kuo: Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A, 101, 266-71 (2004)
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 266-271
    • Kuhnert, F.1    Davis, C.R.2    Wang, H.T.3    Chu, P.4    Lee, M.5    Yuan, J.6    Nusse, R.7    Kuo, C.J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.