Glucose enhances mesangial cell apoptosis

Laboratory Investigation

Volumn 86, Issue 6, 2006, Pages 566-577

  Khera, Tarnjit ^a   Martin, John ^a   Riley, Stephen ^a   Steadman, Robert ^a   Phillips, Aled O ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Diabetes; Glucose; Mesangial cells; TGF

Indexed keywords

CASPASE 3; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; LUCIFERASE; PROTEIN BAX; PROTEIN BCL 2; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPOSURE; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; MEMBRANE POTENTIAL; MESANGIUM CELL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS;

ANIMALS; ANNEXIN A5; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; GLUCOSE; MESANGIAL CELLS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646890643     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700418     Document Type: Article

References (53)

1. White KE, Bilous RW. Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease. J Am Soc Nephrol 2000;11:1667-1673.
2. Kreisberg JI, Venkatachalam M, Troyer D. Contractile properties of cultured glomerular mesangial cells. Am J Physiol 1985;249(4 Part 2):F457-F463.
3. Dworkin LD, Ichikawa I, Brenner BM. Hormonal modulation of glomerular function. Am J Physiol 1983;244:F95-F104.
4. White KE, Bilous RW, Marshall SM, et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes 2002;51:3083-3089.
5. Sharma K, Ziyadeh FN. Hyperglycaemia and diabetic kidney disease. Diabetes 1995;44:1139-1146.
6. Steffes MW, Osterby R, Chavers B, et al. Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 1989;38:1077-1081.
7. Pesce C, Menini S, Pricci F, et al. Glomerular cell replication and cell loss through apoptosis in experimental diabetes mellitus. Nephron 2002;90:484-488.
8. Mishra R, Emancipator SN, Kern T, et al. High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int 2005;67:82-93.
9. Chase HP, Jackson WE, Hoops SL, et al. Glucose control and the renal and retinal complications of insulin dependant diabetes. J Am Med Assoc 1989;261:1155-1160.
10. The Diabetes Control and Complications Research Group. Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial. Kidney Int 1995;47:1703-1720.
11. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin dependant Diabetes Mellitus. N Engl J Med 1993;329:977-986.
12. The diabetes control and complications trial/epidemiology of diabetes intervention and complications research group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med 2000;342:381-389.
13. UK Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylurease or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998;352:837-853.
14. Wolf G, Sharma K, Chen Y, et al. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β. Kidney Int 1992;42:647-656.
15. Ayo SH, Radnik RA, Glass WF, et al. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high glucose medium. Am J Physiol 1991;260:F185-F191.
16. Fumo P, Kuncio G, Ziyadeh FN. PKC and high glucose stimulated collagen α1 (IV) transcriptional activity in a reporter mesangial cell line. Am J Physiol 1994;267:F632-F638.
17. Nahman NS, Leonharat KL, Cosio FG, et al. Effects of high glucose on cellular proliferation and fibronectin production by cultured human mesangial cells. Kidney Int 1992;41:396-402.
18. McLennan SV, Fisher EJ, Yue DK, et al. High glucose concentration causes a decrease in mesangium degradation. Diabetes 1994;43:1041-1046.
19. Laemmli UK. Cleavage of structural proteins during the assembly the head of bacteriophage T4. Nature 1970;227:680-685.
20. Phillips AO, Steadman R, Topley N, et al. Elevated D-glucose concentrations modulate TGF-β1 synthesis by human cultured renal proximal tubular cells: the permissive role of platelet derived growth factor. Am J Pathol 1995;147:362-374.
21. Kochlatyi S, Gibbons N, Mattana J. Extracellular matrix modulates survival, NF-kappaB translocation, and MAPK activity in mesangial cells. Exp Mol Pathol 2002;73:191-197.
22. Hayashida T, Schnaper HW. High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal - regulated kinase and protein kinase Cdelta activities in human mesangial cells. J Am Soc Nephrol 2004;15:2032-2041.
23. Osterby R, Schmitz A, Nyberg G, et al. Renal structural changes in insulin-dependent diabetic patients with albuminuria. Comparison of cases with onset of albuminuria after short or long duration. APMIS 1998;106:361-370.
24. Baker AJ, Mooney A, Hughes J, et al. Mesangial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 1994;94:2105-2116.
25. Sugiyama H, Kashihara N, Makino H, et al. Apoptosis in glomerular sclerosis. Kidney Int 1996;49:103-111.
26. Fiordaliso F, Leri A, Cesselli D, et al. Hyperglycemic activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 2001;50:2363-2375.
27. Du X, Stockklauser-Farber K, Rosen P. Generation of reactive oxygen intermediates, activation of NF-κB and induction of apoptosis in human endothelial cells by glucose. Free Rad Biol Med 1999;27:752-763.
28. Fine EL, Horal M, Chang TI, et al. Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. Diabetes 1999;48:2454-2462.
29. Hall JL, Matter CM, Wang X, et al. Hyperglycemia inhibits vascular smooth muscle cell apoptosis through a protein kinase C-dependent pathway. Circ Res 2000;87:574-580.
30. Carter BD, Kaltschmidt C, Kaltschmidt B, et al. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science 1996;272:542-545.
31. Fraser DJ, Brunskill NJ, Phillips AO. Long-term exposure of proximal tubular epithelial cells to glucose induces TGF-β1 synthesis via an autocrine PDGF loop. Am J Pathol 2003;163:2565-2574.
32. Piek E, Moustakas A, Kurisaki A, et al. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999;112(Part 24): 4557-4568.
33. Brown PD, Wakefield L, Levinson AD, et al. Physiochemical activation of recombinant latent transforming growth factor β's 1, 2 and 3. Growth Factors 1990;3:35-43.
34. Yang B, Johnson TS, Thomas GL, et al. A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis. Kidney Int 2002;62:1301-1313.
35. Barkett M, Gilmore TD. Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 1999;18:6910-6924.
36. Grilli M, Pizzi M, Memo M, et al. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 1996;274:1383-1385.
37. Wu M, Lee H, Bellas RE, et al. Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells. EMBO J 1996;15:4682-4690.
38. Van Antwerp DJ, Martin SJ, Kafri T, et al. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996;274:787-789.
39. Wang CY, Guttridge DC, Mayo MW, et al. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999;19:5923-5929.
40. Wang CY, Mayo MW, Korneluk RG, et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998;281:1680-1683.
41. Fan C, Yang J, Engelhardt JF. Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion. J Cell Sci 2002;115(Part 24): 4843-4853.
42. Furusu A, Nakayama K, Xu Q, et al. Expression, regulation, and function of inhibitor of apoptosis family genes in rat mesangial cells. Kidney Int 2001;60:579-586.
43. Hoffman BB, Sharma K, Zhu Y, et al. Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration. Kidney Int 1998;54:1107-1116.
44. Daniels MC, McClain DA, Crook ED. Transcriptional regulation of transforming growth factor beta1 by glucose: investigation into the role of the hexosamine biosynthesis pathway. Am J Med Sci 2000;319:138-142.
45. Ziyadeh FN, Sharma K, Ericksen M, et al. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor beta. J Clin Invest 1994;93:536-542.
46. Henry DN, Busik JV, Brosius FC, et al. Glucose transporters control gene expression of aldose reductase, PKC and GLUT1 in mesangial cell in vitro. Am J Physiol 1999;277:F97-F104.
47. Silbiger S, Crowley S, Shan Z, et al. Nonenzymatic glycation of mesangial matrix and prolonged exposure of mesangial matrix to elvated glucose reduces collagen synthesis and proteoglycan charge. Kidney Int 1993;43:853-864.
48. Galvez AS, Ulloa JA, Chiong M, et al. Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol. J Biol Chem 2003;278:38484-38494.
49. Naruse K, Nakamura J, Hamada Y, et al. Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes. Exp Eye Res 2000;71:309-315.
50. Quagliaro L, Piconi L, Assaloni R, et al. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003;52:2795-2804.
51. Odetti P, Pesce C, Traverso N, et al. Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes. Diabetes 2003;52:499-505.
52. Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404:787-790.
53. Kang BPS, Frencher S, Reddy V, et al. High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism. Am J Physiol 2003;284:F455-F466.