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Volumn 176, Issue 11, 2006, Pages 6491-6502

Exogenous and endogenous TLR ligands activate anti-chromatin and polyreactive B cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; CARDIOLIPIN; CPG OLIGODEOXYNUCLEOTIDE; GENOMIC DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; LIGAND; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9;

EID: 33646861484     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.11.6491     Document Type: Article
Times cited : (22)

References (74)
  • 1
    • 0242407710 scopus 로고    scopus 로고
    • The regulation of lupus-associated autoantibodies: Immunoglobulin transgenic models
    • Fields, M. L., and J. Erikson. 2003. The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models. Curr. Opin. Immunol. 15: 709-717.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 709-717
    • Fields, M.L.1    Erikson, J.2
  • 2
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan, O. T., L. G. Hannum, A. M. Haberman, M. P. Madaio, and M. J. Shlomchik. 1999. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189: 1639-1648.
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 4
    • 0026750296 scopus 로고
    • Breaking T cell tolerance with foreign and self co-immunogens: A study of autoimmune B and T cell epitopes of cytochrome c
    • Mamula, M. J., R.-H. Lin, J. Charles A. Janeway, and J. A. Hardin. 1992. Breaking T cell tolerance with foreign and self co-immunogens: a study of autoimmune B and T cell epitopes of cytochrome c. J. Immunol. 149: 789-795.
    • (1992) J. Immunol. , vol.149 , pp. 789-795
    • Mamula, M.J.1    Lin, R.-H.2    Charles, J.3    Janeway, A.4    Hardin, J.A.5
  • 5
    • 0742324857 scopus 로고    scopus 로고
    • Toll-like receptors and acquired immunity
    • Pasare, C., and R. Medzhitov. 2004. Toll-like receptors and acquired immunity. Semin. Immunol. 16: 23-26.
    • (2004) Semin. Immunol. , vol.16 , pp. 23-26
    • Pasare, C.1    Medzhitov, R.2
  • 7
    • 0036093704 scopus 로고    scopus 로고
    • A role for Toll in autoimmunity
    • Krieg, A. 2002. A role for Toll in autoimmunity. Nat. Immunol. 3: 423-424.
    • (2002) Nat. Immunol. , vol.3 , pp. 423-424
    • Krieg, A.1
  • 8
    • 0029933460 scopus 로고    scopus 로고
    • Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
    • Ray, S. K., C. Putterman, and B. Diamond. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. USA 93: 2019-2024.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2019-2024
    • Ray, S.K.1    Putterman, C.2    Diamond, B.3
  • 9
    • 0032704761 scopus 로고    scopus 로고
    • Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: Comparisons of phospholipid specificity, avidity and reactivity with β1-GPI
    • Petrovas, C., P. G. Vlachoyiannopoulos, T. Kordossis, and H. M. Moutsopoulos. 1999. Anti-phospholipid antibodies in HIV infection and SLE with or without anti-phospholipid syndrome: comparisons of phospholipid specificity, avidity and reactivity with β1-GPI. J. Autoimmun. 13: 347-355.
    • (1999) J. Autoimmun. , vol.13 , pp. 347-355
    • Petrovas, C.1    Vlachoyiannopoulos, P.G.2    Kordossis, T.3    Moutsopoulos, H.M.4
  • 10
    • 0142218779 scopus 로고    scopus 로고
    • 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease
    • 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease. Ann. Rheum. Dis. 62: 1106-1111.
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 1106-1111
    • Loizou, S.1    Singh, S.2    Wypkema, E.3    Asherson, R.A.4
  • 12
    • 13544254614 scopus 로고    scopus 로고
    • Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
    • Brummel, R., and P. Lenert. 2005. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J. Immunol. 174: 2429-2434.
    • (2005) J. Immunol. , vol.174 , pp. 2429-2434
    • Brummel, R.1    Lenert, P.2
  • 13
    • 0037406582 scopus 로고    scopus 로고
    • Innate immune responses in lupus-prone Palmerston North mice: Differential responses to LPS and bacterial DNA/CpG oligonucleotides
    • Lenert, P., A. Goeken, B. S. Handwerger, and R. F. Ashman. 2003. Innate immune responses in lupus-prone Palmerston North mice: differential responses to LPS and bacterial DNA/CpG oligonucleotides. J. Clin. Immunol. 23: 202-213.
    • (2003) J. Clin. Immunol. , vol.23 , pp. 202-213
    • Lenert, P.1    Goeken, A.2    Handwerger, B.S.3    Ashman, R.F.4
  • 14
    • 15244349648 scopus 로고    scopus 로고
    • TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production
    • Lenert, P., R. Brummel, E. H. Field, and R. F. Ashman. 2005. TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production. J. Clin. Immunol. 25: 29-40.
    • (2005) J. Clin. Immunol. , vol.25 , pp. 29-40
    • Lenert, P.1    Brummel, R.2    Field, E.H.3    Ashman, R.F.4
  • 18
    • 0034460240 scopus 로고    scopus 로고
    • Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1
    • Miyake, K., H. Ogata, Y. Nagai, S. Akashi, and M. Kimoto. 2000. Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1. J. Endotoxin Res. 6: 389-391.
    • (2000) J. Endotoxin Res. , vol.6 , pp. 389-391
    • Miyake, K.1    Ogata, H.2    Nagai, Y.3    Akashi, S.4    Kimoto, M.5
  • 20
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
    • Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product. J. Immunol. 162: 3749-3752.
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 26
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad, P., H. Hacker, M. Rutz, S. Bauer, R. M. Vabulas, and H. Wagner. 2002. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32: 1958-1968.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 27
    • 0037330592 scopus 로고    scopus 로고
    • Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation
    • Wang, Y., and A. M. Krieg. 2003. Synergy between CpG- or non-CpG DNA and specific antigen for B cell activation. Int. Immunol. 15: 223-231.
    • (2003) Int. Immunol. , vol.15 , pp. 223-231
    • Wang, Y.1    Krieg, A.M.2
  • 28
    • 0028923130 scopus 로고
    • Novel packages of viral and self-antigens are generated during apoptosis
    • Rosen, A., L. Casciola-Rosen, and J. Ahearn. 1995. Novel packages of viral and self-antigens are generated during apoptosis. J. Exp. Med. 181: 1557-1561.
    • (1995) J. Exp. Med. , vol.181 , pp. 1557-1561
    • Rosen, A.1    Casciola-Rosen, L.2    Ahearn, J.3
  • 29
    • 0036644073 scopus 로고    scopus 로고
    • Blebs and apoptotic bodies are B cell autoantigens
    • Cocca, B., A. Cline, and M. Radic. 2002. Blebs and apoptotic bodies are B cell autoantigens. J. Immunol. 169: 159-166.
    • (2002) J. Immunol. , vol.169 , pp. 159-166
    • Cocca, B.1    Cline, A.2    Radic, M.3
  • 32
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • Wu, X., and S. L. Peng. 2006. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum. 54: 336-342.
    • (2006) Arthritis Rheum. , vol.54 , pp. 336-342
    • Wu, X.1    Peng, S.L.2
  • 33
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
    • Erikson, J., M. Z. Radic, S. A. Camper, R. R. Hardy, C. Carmack, and M. Weigert. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331-334.
    • (1991) Nature , vol.349 , pp. 331-334
    • Erikson, J.1    Radic, M.Z.2    Camper, S.A.3    Hardy, R.R.4    Carmack, C.5    Weigert, M.6
  • 35
    • 0037501347 scopus 로고    scopus 로고
    • Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
    • Rui, L., C. G. Vinuesa, J. Blasioli, and C. C. Goodnow. 2003. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 4: 594-600.
    • (2003) Nat. Immunol. , vol.4 , pp. 594-600
    • Rui, L.1    Vinuesa, C.G.2    Blasioli, J.3    Goodnow, C.C.4
  • 36
    • 21244498502 scopus 로고    scopus 로고
    • Cutting edge: Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages
    • Kilmon, M. A., J. A. Rutan, S. H. Clarke, and B. J. Vilen. 2005. Cutting edge: low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages. J. Immunol. 175: 37-41.
    • (2005) J. Immunol. , vol.175 , pp. 37-41
    • Kilmon, M.A.1    Rutan, J.A.2    Clarke, S.H.3    Vilen, B.J.4
  • 37
    • 0034141937 scopus 로고    scopus 로고
    • Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells
    • Mandik-Nayak, L., S.-J. Seo, A. Eaton-Bassiri, D. Allman, R. R. Hardy, and J. Erikson. 2000. Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. J. Immunol. 164: 1161-1168.
    • (2000) J. Immunol. , vol.164 , pp. 1161-1168
    • Mandik-Nayak, L.1    Seo, S.-J.2    Eaton-Bassiri, A.3    Allman, D.4    Hardy, R.R.5    Erikson, J.6
  • 38
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
    • Chen, C., Z. Nagy, E. Prak, and M. Weigert. 1995. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3: 747-755.
    • (1995) Immunity , vol.3 , pp. 747-755
    • Chen, C.1    Nagy, Z.2    Prak, E.3    Weigert, M.4
  • 41
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-B cell stages in normal mouse bone marrow
    • Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213-1225.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 43
    • 0031437624 scopus 로고    scopus 로고
    • Following the fate of individual T cells throughout activation and clonal expansion: Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response
    • Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion: signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100: 3173-3183.
    • (1997) J. Clin. Invest. , vol.100 , pp. 3173-3183
    • Wells, A.D.1    Gudmundsdottir, H.2    Turka, L.A.3
  • 44
    • 0033532630 scopus 로고    scopus 로고
    • MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells
    • Mandik-Nayak, L., S.-J. Seo, C. Sokol, K. M. Potts, A. Bui, and J. Erikson. 1999. MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. J. Exp. Med. 189: 1799-1814.
    • (1999) J. Exp. Med. , vol.189 , pp. 1799-1814
    • Mandik-Nayak, L.1    Seo, S.-J.2    Sokol, C.3    Potts, K.M.4    Bui, A.5    Erikson, J.6
  • 46
    • 2442707797 scopus 로고    scopus 로고
    • Nucleosomes are exposed at the cell surface in apoptosis
    • Radic, M., T. Marion, and M. Monestier. 2004. Nucleosomes are exposed at the cell surface in apoptosis. J. Immunol. 172: 6692-6700.
    • (2004) J. Immunol. , vol.172 , pp. 6692-6700
    • Radic, M.1    Marion, T.2    Monestier, M.3
  • 47
    • 0027943184 scopus 로고
    • Light chain editing in κ-deficient animals: A potential mechanism of B cell tolerance
    • Prak, E. L., M. Trounstine, D. Huszar, and M. Weigert. 1994. Light chain editing in κ-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180: 1805-1815.
    • (1994) J. Exp. Med. , vol.180 , pp. 1805-1815
    • Prak, E.L.1    Trounstine, M.2    Huszar, D.3    Weigert, M.4
  • 48
    • 0035881947 scopus 로고    scopus 로고
    • Fas/Fas ligand deficiency results in altered localization of anti-double-stranded DNA B cells and dendritic cells
    • Fields, M. L., C. L. Sokol, A. Eaton-Bassiri, S.-J. Seo, M. P. Madaio, and J. Erikson. 2001. Fas/Fas ligand deficiency results in altered localization of anti-double-stranded DNA B cells and dendritic cells. J. Immunol. 167: 2370-2378.
    • (2001) J. Immunol. , vol.167 , pp. 2370-2378
    • Fields, M.L.1    Sokol, C.L.2    Eaton-Bassiri, A.3    Seo, S.-J.4    Madaio, M.P.5    Erikson, J.6
  • 49
  • 51
    • 0037148509 scopus 로고    scopus 로고
    • Autoreactive B cells in the marginal zone that express dual receptors
    • Li, Y., H. Li, and M. Weigert. 2002. Autoreactive B cells in the marginal zone that express dual receptors. J. Exp. Med. 195: 181-188.
    • (2002) J. Exp. Med. , vol.195 , pp. 181-188
    • Li, Y.1    Li, H.2    Weigert, M.3
  • 52
    • 0030832150 scopus 로고    scopus 로고
    • Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
    • Oliver, A. M., F. Martin, G. L. Gartland, R. H. Carter, and J. F. Kearney. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27: 2366-2374.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2366-2374
    • Oliver, A.M.1    Martin, F.2    Gartland, G.L.3    Carter, R.H.4    Kearney, J.F.5
  • 54
    • 0023631415 scopus 로고
    • Polyreactive autoantibodies are nephritogenic in murine lupus nephritis
    • Pankewycz, O. G., P. Migliorini, and M. P. Madaio. 1987. Polyreactive autoantibodies are nephritogenic in murine lupus nephritis. J. Immunol. 139: 3287-3294.
    • (1987) J. Immunol. , vol.139 , pp. 3287-3294
    • Pankewycz, O.G.1    Migliorini, P.2    Madaio, M.P.3
  • 56
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve, M., K. Xu, Y. S. Ng, H. Wardemann, E. Albesiano, B. T. Messmer, N. Chiorazzi, and E. Meffre. 2005. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J. Clin. Invest. 115: 1636-1643.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3    Wardemann, H.4    Albesiano, E.5    Messmer, B.T.6    Chiorazzi, N.7    Meffre, E.8
  • 58
    • 0032844828 scopus 로고    scopus 로고
    • Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion
    • Goeckeritz, B. E., M. Flora, K. Witherspoon, Q. Vos, A. Lees, G. J. Dennis, D. S. Pisetsky, D. M. Klinman, C. M. Snapper, and J. J. Mond. 1999. Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion. Int. Immunol. 11: 1693-1700.
    • (1999) Int. Immunol. , vol.11 , pp. 1693-1700
    • Goeckeritz, B.E.1    Flora, M.2    Witherspoon, K.3    Vos, Q.4    Lees, A.5    Dennis, G.J.6    Pisetsky, D.S.7    Klinman, D.M.8    Snapper, C.M.9    Mond, J.J.10
  • 60
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-DNA antibodies
    • Radic, M. Z., and M. Weigert. 1994. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12: 487-520.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 61
    • 0034532972 scopus 로고    scopus 로고
    • Diverse roles for the third complementarity determining region of the heavy chain (H3) in the binding of immunoglobulin Fv fragments to DNA, nucleosomes and cardiolipin
    • Seal, S. N., M. Monestier, and M. Z. Radic. 2000. Diverse roles for the third complementarity determining region of the heavy chain (H3) in the binding of immunoglobulin Fv fragments to DNA, nucleosomes and cardiolipin. Eur. J. Immunol. 30: 3432-3440.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3432-3440
    • Seal, S.N.1    Monestier, M.2    Radic, M.Z.3
  • 62
    • 0030827382 scopus 로고    scopus 로고
    • Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: Localization to the T-B interface of the splenic follicle
    • Mandik-Nayak, L., A. Bui, H. Noorchashm, A. Eaton, and J. Erikson. 1997. Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle. J. Exp. Med. 186: 1257-1267.
    • (1997) J. Exp. Med. , vol.186 , pp. 1257-1267
    • Mandik-Nayak, L.1    Bui, A.2    Noorchashm, H.3    Eaton, A.4    Erikson, J.5
  • 63
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M. Z., J. Erikson, S. Litwin, and M. Weigert. 1993. B lymphocytes may escape tolerance by revising their antigen receptors. J, Exp. Med. 177: 1165-1173.
    • (1993) J, Exp. Med. , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 64
    • 1342342916 scopus 로고    scopus 로고
    • Editing anti-DNA B cells by Vλx
    • Li, Y., Y. Louzoun, and M. Weigert. 2004. Editing anti-DNA B cells by Vλx. J. Exp. Med. 199: 337-346.
    • (2004) J. Exp. Med. , vol.199 , pp. 337-346
    • Li, Y.1    Louzoun, Y.2    Weigert, M.3
  • 66
    • 0027279173 scopus 로고
    • Polyreactivity is a property of natural and disease-associated human autoantibodies
    • Hurez, V., G. Dietrich, S. V. Kaveri, and M. D. Kazatchkine. 1993. Polyreactivity is a property of natural and disease-associated human autoantibodies. Scand. J. Immunol. 38: 190-196.
    • (1993) Scand. J. Immunol. , vol.38 , pp. 190-196
    • Hurez, V.1    Dietrich, G.2    Kaveri, S.V.3    Kazatchkine, M.D.4
  • 67
    • 0031905272 scopus 로고    scopus 로고
    • Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire
    • Chen, Z. J., C. J. Wheeler, W. Shi, A. J. Wu, C. H. Yarboro, M. Gallagher, and A. L. Notkins. 1998. Polyreactive antigen-binding B cells are the predominant cell type in the newborn B cell repertoire. Eur. J. Immunol. 28: 989-994.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 989-994
    • Chen, Z.J.1    Wheeler, C.J.2    Shi, W.3    Wu, A.J.4    Yarboro, C.H.5    Gallagher, M.6    Notkins, A.L.7
  • 69
    • 19344374510 scopus 로고    scopus 로고
    • Impaired early B cell tolerance in patients with rheumatoid arthritis
    • Samuels, J., Y. S. Ng, C. Coupillaud, D. Paget, and E. Meffre. 2005. Impaired early B cell tolerance in patients with rheumatoid arthritis. J. Exp. Med. 201: 1659-1667.
    • (2005) J. Exp. Med. , vol.201 , pp. 1659-1667
    • Samuels, J.1    Ng, Y.S.2    Coupillaud, C.3    Paget, D.4    Meffre, E.5
  • 71
    • 0023277281 scopus 로고
    • Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits
    • Madaio, M. P., J. Carlson, J. Cataldo, A. Ucci, P. Migliorini, and O. Pankewycz. 1987. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. Immunol. 138: 2883-2889.
    • (1987) J. Immunol. , vol.138 , pp. 2883-2889
    • Madaio, M.P.1    Carlson, J.2    Cataldo, J.3    Ucci, A.4    Migliorini, P.5    Pankewycz, O.6
  • 72
    • 0034041159 scopus 로고    scopus 로고
    • Lupus, DNase and defective disposal of cellular debris
    • Walport, M. 2000. Lupus, DNase and defective disposal of cellular debris. Nat. Genet. 25: 135-136.
    • (2000) Nat. Genet. , vol.25 , pp. 135-136
    • Walport, M.1
  • 73
    • 0034957380 scopus 로고    scopus 로고
    • Clearing the way to mechanisms of autoimmunity
    • Rosen, A., and L. Casciola-Rosen. 2001. Clearing the way to mechanisms of autoimmunity. Nat. Med. 7: 664-665.
    • (2001) Nat. Med. , vol.7 , pp. 664-665
    • Rosen, A.1    Casciola-Rosen, L.2


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