Diverse roles for the third complementarity determining region of the heavy chain (H3) in the binding of immunoglobulin Fv fragments to DNA, nucleosomes and cardiolipin

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3432-3440

  Seal, Samarendra N ^a   Monestier, Marc ^b,c   Radic, Marko Z ^a,c  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Autoantibody; Generation of diversity; Lupus

Indexed keywords

AUTOANTIBODY; CARDIOLIPIN; CELL NUCLEUS ANTIGEN; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; SINGLE STRANDED DNA;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CHROMATIN; COMPLEMENTARITY DETERMINING REGION; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GERM LINE; LUPUS ERYTHEMATOSUS; MOUSE; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC MUTATION;

AMINO ACID SEQUENCE; CARDIOLIPINS; CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; DNA; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; MOLECULAR SEQUENCE DATA; NUCLEOSOMES;

EID: 0034532972     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2000012)30:12<3432::AID-IMMU3432>3.0.CO;2-H     Document Type: Article

References (39)

1. Somatic generation of antibody diversity
2. B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound D mu protein and selection of DH element raading frames
3. X-ray crystallography of antibodies
4. Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes
5. The crystal structure of a T cell receptor in complex with peptide and MHC class II
6. Antibody-antigen interactions: New structuras and new conformational changes
7. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
8. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice
9. Structure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies
10. Genetic and structural evidence for antigen selection of anti-DNA antibodies
11. Corralation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies
12. Residues that mediate DNA binding of autoimmune antibodies
13. The structural basis for DNA binding by an anti-DNA autoantibody
14. Structural elements controlling anti-DNA antibody affinity and their relationship to anti-phosphorylcholine activity
15. Use of phage surface expression to analyze regions of human V4-34 (VH 4-21)-encoded IgG autoantibody required for recognition of DNA: No involvement of the 9G4 idiotope
16. Equilibrium binding studies of recombinant anti-single-stranded DNA Fab. Role of heavy chain complementarity-determining regions
17. Transplantation of a 17-amino acid alpha-helical DNA-binding domain into an antibody molecule confers sequence-dependent DNA racognition
18. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
19. IgH and L chain contributions to autoimmune specificities
20. Light chain contribution to specificity in anti-DNA antibodies
21. Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice
22. Molecular analysis of mercury-induced antinucleolar antibodies in H-2S mice
23. Structural classification of CDR-H3 in antibodies
24. Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex
25. Crystal structure of a catalytic antibody with a serine protease active site
26. Conformations of the third hypervariable region in the VH domain of immunoglobulins
27. H3-rules: Identification of CDR-H3 structures in antibodies
28. V gene analysis of anticardiolipin antibodies from MRL-Ipr/Ipr mice
29. Monoclonal antibodies from NZW x BXSB F1 mice to beta2 glycoprotein I and cardiolipin. Species specificity and charge-dependent binding
30. Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNA
31. Modeling of anti-nucleosome immunoglobulin Fv domains: Analysis of electrostatic interactions
32. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids
33. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein
34. Flexibility of DNA
35. Crystal structure of the nucleosome core particle at 2.8 Å resolution
36. Most peripheral B cells in mice are ligand selected
37. Junctional amino acids determine the maturation pathway of an antibody
38. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system
39. Tandem affinity tags for the purification of bivalent anti-DNA single chain Fv expressed in E. coli