Targeting cytosolic phospholipase A2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice

European Journal of Pharmacology

Volumn 539, Issue 3, 2006, Pages 195-204

  Malaviya, Ravi ^a   Ansell, Justin ^a   Hall, LeRoy ^a   Fahmy, Mila ^a   Argentieri, Rochelle L ^a   Olini Jr , Gilbert C ^a   Pereira, David W ^a   Sur, Runa ^a   Cavender, Druie ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Acute; Chronic; Inflammation; Inhibitor; Phospholipase A2

Indexed keywords

ARACHIDONYL TRIFLUOROMETHYL KETONE; BMS 229724; OVALBUMIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOSOL; DRUG TARGETING; EAR DISEASE; EDEMA; EXPERIMENTAL MODEL; FEMALE; INFLAMMATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION;

ALLERGENS; ANIMALS; ARACHIDONIC ACIDS; ASTHMA; CELL MOVEMENT; CHRONIC DISEASE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; EDEMA; ENZYME INHIBITORS; FEMALE; INFLAMMATION; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; PHOSPHOLIPASES A;

EID: 33646857678     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.03.018     Document Type: Article

References (66)

1. 2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270 (1995) 445-450
2. Arm J.P., and Lee T.H. The pathobiology of bronchial asthma. Adv. Immunol. 51 (1992) 323-382
3. 2. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 175-189
4. 2 inhibit release of free arachidonate in thrombin-stimulated human platelets. J. Biol. Chem. 269 (1994) 15625-15630
5. 2 knockout mouse: A new tool for physiology and cell biology. J. Am. Soc. Nephrol. 10 (1999) 404-412
6. 2) function: insights from the knockout mouse. Adv. Exp. Med. Biol. 507 (2002) 25-31
7. 2 by phosphorylation. Biochem. Soc. Trans. 26 (1998) 350-354
8. 2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. J. Pharmacol. Exp. Ther. 298 (2001) 376-385
9. Camandola S., Leonarduzzi G., Musso T., Varesio L., Carini R., Scavazza A., Chiarpotto E., Baeuerle P.A., and Poli G. Nuclear factor kB is activated by arachidonic acid but not by eicosapentaenoic acid. Biochem. Biophys. Res. Commun. 229 (1996) 643-647
10. Carlson R.P., O'Neill-Davis L., Chang J., and Lewis A.J. Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents. Agents Actions 17 (1985) 197-204
11. Clarkson M.R., McGinty A., Godson C., and Brady H.R. Leukotrienes and lipoxins: Lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis. Nephrol. Dial. Transplant. 13 (1998) 3043-3051
12. Drazen J.M., Arm J.P., and Austen K.F. Sorting out the cytokines of asthma. J. Exp. Med. 183 (1996) 1-5
13. Fitzpatrick F.A., and Soberman R. Regulated formation of eicosanoids. J. Clin. Invest. 107 (2001) 1347-1351
14. Fosslien E. Cardiovascular complications of non-steroidal anti-inflammatory drugs. Ann. Clin. Lab. Sci. 35 (2005) 347-385
15. 2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proc. Natl. Acad. Sci. USA 96 (1999) 4803-4807
16. 2. Br. J. Pharmacol. 126 (1999) 301-311
17. Garcia Rodriguez L.A. The effect of nsaids on the risk of coronary heart disease: Fusion of clinical pharmacology and pharmacoepidemiologic data. Clin. Exp. Rheumatol. 19 (2001) S41-S44
18. 2. Semin. Cell. Dev. Biol. 8 (1997) 297-303
19. 2 activation. J. Leukoc. Biol. 65 (1999) 330-336
20. Hamelmann E., Schwarze J., Takeda K., Oshiba A., Larsen G.L., Irvin C.G., and Gelfand E.W. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care. Med. 156 (1997) 766-775
21. Hamelmann E., Vella A.T., Oshiba A., Kappler J.W., Marrack P., and Gelfand E.W. Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice. Proc. Natl. Acad. Sci. U. S. A 94 (1997) 1350-1355
22. 2α-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197 (2003) 1297-1302
23. Henderson Jr. W.R. Role of leukotrienes in asthma. Ann. Allergy. 72 (1994) 272-278
24. Henderson Jr. W.R., Lewis D.B., Albert R.K., Zhang Y., Lamm W.J., Chiang G.K., Jones F., Eriksen P., Tien Y.T., Jonas M., and Chi E.Y. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J. Exp. Med. 184 (1996) 1483-1494
25. Henderson Jr. W.R., Tang L.O., Chu S.J., Tsao S.M., Chiang G.K., Jones F., Jonas M., Pae C., Wang H., and Chi E.Y. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am. J. Respir. Crit. Care. Med. 165 (2002) 108-116
26. Huber R., Berendes R., Burger A., Luecke H., and Karshikov A. Annexin V-crystal structure and its implications on function. Behring-Inst-Mitt (1992) 107-125
27. Hunt J.E., Stevens R.L., Austen K.F., Zhang J., Xia Z., and Ghildyal N. Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse. J. Biol. Chem. 271 (1996) 2851-2855
28. Ichinose F., Ullrich R., Sapirstein A., Jones R.C., Bonventre J.V., Serhan C.N., Bloch K.D., and Zapol W.M. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J. Clin. Invest. 109 (2002) 1493-1500
29. 2 plays a key role in the pathogenesis of multiple sclerosis-like disease. Neuron. 41 (2004) 323-335
30. 2. J. Biol. Chem. 271 (1996) 27723-27729
31. 2). FEBS Lett. 410 (1997) 49-53
32. Krotz F., Schiele T.M., Klauss V., and Sohn H.Y. Selective cox-2 inhibitors and risk of myocardial infarction. J. Vasc. Res. 42 (2005) 312-324
33. 2 expression in tumours: A target for therapeutic intervention?. Drug. Discov. Today. 8 (2003) 710-716
34. Leong K.P., and Huston D.P. Understanding the pathogenesis of allergic asthma using mouse models. Ann. Allergy Asthma & Immun. 87 (2001) 96-109 (quiz 110)
35. Linton M.F., and Fazio S. Cyclooxygenase-2 and inflammation in atherosclerosis. Curr. Opin. Pharmacol. 4 (2004) 116-123
36. Lloyd C.M., Gonzalo J.A., Coyle A.J., and Gutierrez-Ramos J.C. Mouse models of allergic airway disease. Adv. Immunol. 77 (2001) 263-295
37. Malaviya R., and Abraham S.N. Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. J. Leukoc. Biol. 67 (2000) 841-846
38. Malaviya R., and Uckun F.M. Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. Am. J. Ther. 8 (2001) 309-316
39. Malaviya R., Malaviya R., and Jakschik B.A. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J. Biol. Chem. 268 (1993) 4939-4944
40. Malaviya R., Ikeda T., Ross E., and Abraham S.N. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381 (1996) 77-80
41. Malaviya R., Chen C.L., Navara C., Liu X.P., Keenan M., Waurzyniak B., and Uckun F.M. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J. Pharmacol. Exp. Ther. 295 (2000) 912-926
42. 2-inhibition. Nat. Immunol. 2 (2001) 145-149
43. Nagase T., Uozumi N., Ishii S., Kita Y., Yamamoto H., Ohga E., Ouchi Y., and Shimizu T. A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat. Med. 8 (2002) 480-484
44. 2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am. J. Physiol. Lung. Cell. Mol. Physiol. 284 (2003) L720-L726
45. 2 in rat mastocytoma RBL-2H3. Biol. Pharm. Bull. 17 (1994) 47-50
46. 2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells. Biochem. J. 352 Pt 2 (2000) 311-317
47. 2 receptor antagonist (Bay u 3405) on nasal symptoms after antigen challenge in sensitized guinea pigs. Int. Arch. Allergy. Immunol. 109 (1996) 161-166
48. Paller M.S., and Manivel J.C. Prostaglandins protect kidneys against ischemic and toxic injury by a cellular effect. Kidney Int. 42 (1992) 1345-1354
49. 2. J. Biol. Chem. 269 (1994) 19480-19487
50. 2 activity is increased in guinea pig uterine cervix in late pregnancy and at parturition. Am. J. Physiol. 269 (1995) E940-E947
51. Ramos B.F., Zhang Y., and Jakschik B.A. Mast cells contribute to fibrin deposition in reverse passive Arthus reaction in mouse skin. Eur. J. Immunol. 22 (1992) 2381-2385
52. Reddy S.T., and Herschman H.R. Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin d2 in activated mast cells. J. Biol. Chem. 272 (1997) 3231-3237
53. Reder A.T., Thapar M., Sapugay A.M., and Jensen M.A. Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis. J. Neuroimmunol. 54 (1994) 117-127
54. Riendeau D., Guay J., Weech P.K., Laliberte F., Yergey J., Li C., Desmarais S., Perrier H., Liu S., Nicoll-Griffith D., et al. Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J. Biol. Chem. 269 (1994) 15619-15624
55. Sapirstein A., and Bonventre J.V. Specific physiological roles of cytosolic phospholipase a(2) as defined by gene knockouts. Biochim. Biophys. Acta 1488 (2000) 139-148
56. Spahr J.E., and Krawiec M.E. Leukotriene receptor antagonists-Risks and benefits for use in paediatric asthma. Expert. Opin. Drug Saf. 3 (2004) 173-185
57. Stanley P.L., Steiner S., Havens M., and Tramposch K.M. Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate. Skin Pharmacol. 4 (1991) 262-271
58. 2. Biochemistry 32 (1993) 5935-5940
59. Sundy J.S. COX-2 inhibitors in rheumatoid arthritis. Curr. Rheumatol. Rep. 3 (2001) 86-91
60. Takeda K., Hamelmann E., Joetham A., Shultz L.D., Larsen G.L., Irvin C.G., and Gelfand E.W. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J. Exp. Med. 186 (1997) 449-454
61. Tomimori Y., Tsuruoka N., Fukami H., Saito K., Horikawa C., Saito M., Muto T., Sugiura N., Yamashiro K., Sumida M., Kakutani S., and Fukuda Y. Role of mast cell chymase in allergen-induced biphasic skin reaction. Biochem. Pharmacol. 64 (1994) 1187
62. 2 in allergic response and parturition. Nature 390 (1997) 618-622
63. van der Weiden R.M., Wisse L.J., Helmerhorst F.M., Keirse M.J., and Poelmann R.E. Immunohistochemical and ultrastructural localization of prostaglandin h synthase in the preimplantation mouse embryo. J. Reprod. Fertil. 107 (1996) 161-166
64. Vignola A.M., Mirabella F., Costanzo G., Di Giorgi R., Gjomarkaj M., Bellia V., and Bonsignore G. Airway remodeling in asthma. Chest 123 (2003) 417S-422S
65. Wasserman S.I. Mast cells and airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 150 (1994) S39-S41
66. Wershil B.K., Murakami T., and Galli S.J. Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate. J. Immunol. 140 (1988) 2356-2360