Leflunomide metabolite analogue α-cyano-β-hydroxy-β-methyl-n-[3-(trifluoromethyl)phenyl] propenamide inhibits IgE/fc∈ri receptor-mediated mast cell leukotriene release and allergic asthma in mice

American Journal of Therapeutics

Volumn 8, Issue 5, 2001, Pages 309-316

  Malaviya, Ravi ^a   Uckun, Fatih M ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Allergic asthma; Leflunomide; Mast cell

Indexed keywords

IMMUNOGLOBULIN E RECEPTOR; IMMUNOLOGICAL ADJUVANT; ISOXAZOLE DERIVATIVE; LEFLUNOMIDE; LEUKOTRIENE C4;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; DRUG EFFECT; MAST CELL; METABOLISM; MOUSE; PATHOPHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ASTHMA; ISOXAZOLES; LEUKOTRIENE C4; MAST CELLS; MICE; MICE, INBRED BALB C; RECEPTORS, IGE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035459593     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200109000-00002     Document Type: Article

References (5)

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2. Galli SJ: New concepts about the mast cell. N Engl J Med 1993;328:257-265.
3. Metcalfe DD, Baram D, Mekori YA: Mast cells. Physiol Rev 1997;77:1033-1079.
4. Malaviya R, Chen C-L, Malaviya R, et al: Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′-,5′-dibromo-4′-hydroxyphenyl)-amino-6,7- dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther 2000;295:912-926.
5. Malaviya R, Malaviya R, Jakschik BA: Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem 1993;268:4939-4944.