Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A

Journal of Biological Chemistry

Volumn 281, Issue 9, 2006, Pages 6000-6009

  Choudhary, Saba ^a   Doherty, Kevin M ^a   Handy, Christopher J ^a   Sayer, Jane M ^a   Yagi, Haruhiko ^a   Jerina, Donald M ^a   Brosh Jr , Robert M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINES; CELLS; DNA; ENZYME INHIBITION; MOLECULAR BIOLOGY;

DNA HARBORING; DNA STRUCTURES; TRANSLOCATING STRANDS; WRN HELICASE ACTIVITY;

ENZYME KINETICS;

DEOXYADENOSINE; DEOXYGUANOSINE; DIHYDROXYBENZO[A]PYRENE OXIDE; HELICASE; REPLICATION PROTEIN A; WERNER SYNDROME PROTEIN; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; DEOXYADENOSINE DERIVATIVE; DNA; EPOXIDE; RECQ HELICASE; WRN PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA HELIX; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DNA ADDUCT; DNA DAMAGE; DNA REPLICATION; DRUG ANTAGONISM; METABOLISM;

ANIMALS; DEOXYADENOSINES; DEOXYGUANOSINE; DIHYDROXYDIHYDROBENZOPYRENES; DNA; DNA ADDUCTS; DNA DAMAGE; DNA HELICASES; DNA REPLICATION; EPOXY COMPOUNDS; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; RECQ HELICASES; REPLICATION PROTEIN A;

EID: 33646846505     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510122200     Document Type: Article

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