Crawling and wiggling on DNA: Structural insights to the mechanism of DNA unwinding by helicases

Structure

Volumn 8, Issue 12, 2000, Pages

  Marians, K J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DNA PRIMASE; HELICASE;

BACTERIOPHAGE T7; CRYSTAL STRUCTURE; DNA STRUCTURE; GENE REPLICATION; GENE TRANSLOCATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; SHORT SURVEY;

BACTERIA (MICROORGANISMS);

EID: 0034479416     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00539-6     Document Type: Review

References (31)

1. Enzymic unwinding of DNA 2. Chain separation by an ATP-dependent DNA unwinding enzyme
2. A mechanism of duplex DNA replication revealed by enzymatic studies of phage φX174: Catalytic strand separation in advance of replication
3. DNA helicases
4. Mechanisms of helicase-catalyzed DNA unwinding
5. Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding
6. Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism
7. Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7
8. Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides
9. Crystal structure of a DExx box DNA helicase
10. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP
11. Helicases: Amino acid sequence comparisons and structure-function relationships
12. Complexes of Rep protein with ATP and DNA as a basis for helicase action
13. Enzyme-catalyzed DNA unwinding: Studies on Escherichia coli Rep protein
14. Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA
15. Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: Measurement of step size and translocation speed
16. Differential ATP requirements distinguish the DNA translocation and DNA unwinding activities of the Escherichia coli PriA protein
17. Uncoupling DNA translocation and helicase activity in PcrA: Direct evidence for an active mechanism
18. Escherichia coli helicase II (UvrD) protein initiates DNA unwinding at nicks and blunt ends
19. Prokaryotic DNA replication
20. Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases
21. 1-ATPase
22. The binding change mechanism for ATP synthase - Some probabilities and possibilities
23. Cooperative interactions of nucleotide ligands are linked to oligomerization and DNA binding in bacteriophage T7 gene 4 helicases
24. DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase
25. 1-ATPase is a highly efficient molecular motor that rotates with discrete 120° steps
26. Coupling of a replicative polymerase and helicase: A τ-DnaB interaction mediates rapid replication fork movement
27. The 3′-tail of a forked-duplex sterically determines whether one or two DNA strands pass through the central channel of a replication-fork helicase
28. Interactions of the DNA polymerase and gene 4 protein of bacteriophage T7. Protein-protein and protein-DNA interactions involved in RNA-primed DNA synthesis
29. A coupled complex of T4 DNA replication helicase (gp41) and polymerase (gp43) can perform rapid and processive DNA strand-displacement synthesis
30. Ribbons 2.0
31. 1-ATPase