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Volumn 107, Issue 10, 2006, Pages 3983-3991

T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALPHOSTIN; GAMMA INTERFERON; ROTTLERIN; TRANSCRIPTION FACTOR T BET;

EID: 33646546357     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-10-4201     Document Type: Article
Times cited : (127)

References (55)
  • 1
    • 0037006957 scopus 로고    scopus 로고
    • Acquired aplastic anemia
    • Young NS. Acquired aplastic anemia. Ann Intern Med. 2002;136:534-546.
    • (2002) Ann Intern Med , vol.136 , pp. 534-546
    • Young, N.S.1
  • 2
    • 0030912049 scopus 로고    scopus 로고
    • The pathophysiology of acquired aplastic anemia
    • Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. N Engl J Med. 1997;336:1365-1372.
    • (1997) N Engl J Med , vol.336 , pp. 1365-1372
    • Young, N.S.1    Maciejewski, J.2
  • 3
    • 0033983205 scopus 로고    scopus 로고
    • Introduction: Acquired aplastic anemia
    • Young NS. Introduction: acquired aplastic anemia. Semin Hematol. 2000;37:2.
    • (2000) Semin Hematol , vol.37 , pp. 2
    • Young, N.S.1
  • 4
    • 0033950194 scopus 로고    scopus 로고
    • Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia
    • Young NS. Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia. Semin Hematol. 2000;37:3-14.
    • (2000) Semin Hematol , vol.37 , pp. 3-14
    • Young, N.S.1
  • 5
    • 0031025354 scopus 로고    scopus 로고
    • Autoimmunity and its treatment in aplastic anemia
    • Young NS. Autoimmunity and its treatment in aplastic anemia. Ann Intern Med. 1997;126:166-168.
    • (1997) Ann Intern Med , vol.126 , pp. 166-168
    • Young, N.S.1
  • 6
    • 0036463753 scopus 로고    scopus 로고
    • Immunosuppressive treatment of acquired aplastic anemia and immune-mediated bone marrow failure syndromes
    • Young NS. Immunosuppressive treatment of acquired aplastic anemia and immune-mediated bone marrow failure syndromes. Int J Hematol. 2002;75:129-140.
    • (2002) Int J Hematol , vol.75 , pp. 129-140
    • Young, N.S.1
  • 7
    • 0023376168 scopus 로고
    • Gamma interferon and aplastic anemia
    • Young NS. Gamma interferon and aplastic anemia. Blood. 1987;70:337-339.
    • (1987) Blood , vol.70 , pp. 337-339
    • Young, N.S.1
  • 8
    • 1842402749 scopus 로고
    • Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo
    • U S A
    • Zoumbos NC, Gascon P, Djeu JY, Young NS. Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc Natl Acad Sci U S A. 1985;82:188-192.
    • (1985) Proc Natl Acad Sci , vol.82 , pp. 188-192
    • Zoumbos, N.C.1    Gascon, P.2    Djeu, J.Y.3    Young, N.S.4
  • 9
    • 9144270491 scopus 로고    scopus 로고
    • Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients
    • Giannakoulas NC, Karakantza M, Theodorou GL, et al. Clinical relevance of balance between type 1 and type 2 immune responses of lymphocyte subpopulations in aplastic anaemia patients. Br J Haematol. 2004;124:97-105.
    • (2004) Br J Haematol , vol.124 , pp. 97-105
    • Giannakoulas, N.C.1    Karakantza, M.2    Theodorou, G.L.3
  • 10
    • 0037103384 scopus 로고    scopus 로고
    • Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia
    • Sloand E, Kim S, Maciejewski JP, et al. Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood. 2002;100:1185-1191.
    • (2002) Blood , vol.100 , pp. 1185-1191
    • Sloand, E.1    Kim, S.2    Maciejewski, J.P.3
  • 11
    • 0021240611 scopus 로고
    • Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro
    • Zoumbos NC, Djeu JY, Young NS. Interferon is the suppressor of hematopoiesis generated by stimulated lymphocytes in vitro. J Immunol. 1984;133:769-774.
    • (1984) J Immunol , vol.133 , pp. 769-774
    • Zoumbos, N.C.1    Djeu, J.Y.2    Young, N.S.3
  • 12
    • 0023245369 scopus 로고
    • Lymphocytes and lymphokines in aplastic anemia: Pathogenic role and implications for pathogenesis
    • Young NS, Leonard E, Platanias L. Lymphocytes and lymphokines in aplastic anemia: pathogenic role and implications for pathogenesis. Blood Cells. 1987;13:87-100.
    • (1987) Blood Cells , vol.13 , pp. 87-100
    • Young, N.S.1    Leonard, E.2    Platanias, L.3
  • 13
    • 3242782610 scopus 로고    scopus 로고
    • Invivo dominant immune responses in aplastic anaemia: Molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing
    • Risitano AM, Maciejewski JP, Green S, et al. Invivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing. Lancet. 2004;364:355-364.
    • (2004) Lancet , vol.364 , pp. 355-364
    • Risitano, A.M.1    Maciejewski, J.P.2    Green, S.3
  • 15
    • 10044264467 scopus 로고    scopus 로고
    • A mouse model of lymphocyte infusion-induced bone marrow failure
    • Bloom ML, Wolk AG, Simon-Stoos KL, et al. A mouse model of lymphocyte infusion-induced bone marrow failure. Exp Hematol. 2004;32:1163-1172.
    • (2004) Exp Hematol , vol.32 , pp. 1163-1172
    • Bloom, M.L.1    Wolk, A.G.2    Simon-Stoos, K.L.3
  • 16
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655-669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3
  • 17
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo SJ, Sullivan BM, Stemmann C, et al. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295:338-342.
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3
  • 18
    • 0033791427 scopus 로고    scopus 로고
    • Transcriptional regulation of Th1/Th2 polarization
    • Rengarajan J, Szabo SJ, Glimcher LH. Transcriptional regulation of Th1/Th2 polarization. Immunol Today. 2000;21:479-483.
    • (2000) Immunol Today , vol.21 , pp. 479-483
    • Rengarajan, J.1    Szabo, S.J.2    Glimcher, L.H.3
  • 19
    • 0029732843 scopus 로고    scopus 로고
    • The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells
    • Penix LA, Sweetser MT, Weaver WM, et al. The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells. J Biol Chem. 1996;271:31964-31972.
    • (1996) J Biol Chem , vol.271 , pp. 31964-31972
    • Penix, L.A.1    Sweetser, M.T.2    Weaver, W.M.3
  • 20
    • 0032567436 scopus 로고    scopus 로고
    • The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells
    • Sweetser MT, Hoey T, Sun YL, et al. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells. J Biol Chem. 1998;273:34775-34783.
    • (1998) J Biol Chem , vol.273 , pp. 34775-34783
    • Sweetser, M.T.1    Hoey, T.2    Sun, Y.L.3
  • 21
    • 13844320399 scopus 로고    scopus 로고
    • T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site
    • U S A
    • Tong Y, Aune T, Boothby M. T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A. 2005;102:2034-2039.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 2034-2039
    • Tong, Y.1    Aune, T.2    Boothby, M.3
  • 22
    • 1442283556 scopus 로고    scopus 로고
    • T cell directives for transcriptional regulation in asthma
    • Finotto S, Glimcher L. T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol. 2004;25:281-294.
    • (2004) Springer Semin Immunopathol , vol.25 , pp. 281-294
    • Finotto, S.1    Glimcher, L.2
  • 23
    • 0642377166 scopus 로고    scopus 로고
    • Immunology: T-bet or not T-bet
    • Hatton RD, Weaver CT. Immunology: T-bet or not T-bet. Science. 2003;302:993-994.
    • (2003) Science , vol.302 , pp. 993-994
    • Hatton, R.D.1    Weaver, C.T.2
  • 24
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002;295:336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3
  • 25
    • 0035997908 scopus 로고    scopus 로고
    • T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
    • Afkarian M, Sedy JR, Yang J, et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol. 2002;3:549-557.
    • (2002) Nat Immunol , vol.3 , pp. 549-557
    • Afkarian, M.1    Sedy, J.R.2    Yang, J.3
  • 26
    • 0036301997 scopus 로고    scopus 로고
    • Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction
    • Mullen AC, Hutchins AS, High FA, et al. Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol. 2002;3:652-658.
    • (2002) Nat Immunol , vol.3 , pp. 652-658
    • Mullen, A.C.1    Hutchins, A.S.2    High, F.A.3
  • 27
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase C(theta) in T cell activation
    • Isakov N, Altman A. Protein kinase C(theta) in T cell activation. Annu Rev Immunol. 2002;20:761-794.
    • (2002) Annu Rev Immunol , vol.20 , pp. 761-794
    • Isakov, N.1    Altman, A.2
  • 28
    • 0033625869 scopus 로고    scopus 로고
    • Protein kinase Ctheta: A new essential superstar on the T-cell stage
    • Altman A, Isakov N, Baier G. Protein kinase Ctheta: a new essential superstar on the T-cell stage. Immunol Today. 2000;21:567-573.
    • (2000) Immunol Today , vol.21 , pp. 567-573
    • Altman, A.1    Isakov, N.2    Baier, G.3
  • 29
    • 5744224686 scopus 로고    scopus 로고
    • Therapeutic potential of natural compounds that regulate the activity of protein kinase C
    • Carter CA, Kane CJ. Therapeutic potential of natural compounds that regulate the activity of protein kinase C. Curr Med Chem. 2004;11:2883-2902.
    • (2004) Curr Med Chem , vol.11 , pp. 2883-2902
    • Carter, C.A.1    Kane, C.J.2
  • 30
    • 0035340310 scopus 로고    scopus 로고
    • Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes
    • Solomou EE, Juang YT, Tsokos GC. Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. J Immunol. 2001;166:5665-5674.
    • (2001) J Immunol , vol.166 , pp. 5665-5674
    • Solomou, E.E.1    Juang, Y.T.2    Tsokos, G.C.3
  • 31
    • 0034724201 scopus 로고    scopus 로고
    • NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
    • U S A
    • Coudronniere N, Villalba M, Englund N, Altman A. NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta. Proc Natl Acad Sci U S A. 2000;97:3394-3399.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 3394-3399
    • Coudronniere, N.1    Villalba, M.2    Englund, N.3    Altman, A.4
  • 32
    • 0029790656 scopus 로고    scopus 로고
    • FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
    • Tan Y, Rouse J, Zhang A, et al. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 1996;15:4629-4642.
    • (1996) EMBO J , vol.15 , pp. 4629-4642
    • Tan, Y.1    Rouse, J.2    Zhang, A.3
  • 33
    • 0032479983 scopus 로고    scopus 로고
    • Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
    • Deak M, Clifton AD, Lucocq LM, Alessi DR. Mitogen-and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 1998;17:4426-4441.
    • (1998) EMBO J , vol.17 , pp. 4426-4441
    • Deak, M.1    Clifton, A.D.2    Lucocq, L.M.3    Alessi, D.R.4
  • 34
    • 0035869333 scopus 로고    scopus 로고
    • Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
    • Solomou EE, Juang YT, Gourley MF, Kammer GM, Tsokos GC. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunol. 2001;166:4216-4222.
    • (2001) J Immunol , vol.166 , pp. 4216-4222
    • Solomou, E.E.1    Juang, Y.T.2    Gourley, M.F.3    Kammer, G.M.4    Tsokos, G.C.5
  • 35
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-433.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 36
    • 9644257195 scopus 로고    scopus 로고
    • Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
    • Watford WT, Hissong BD, Bream JH, et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 2004;202:139-156.
    • (2004) Immunol Rev , vol.202 , pp. 139-156
    • Watford, W.T.1    Hissong, B.D.2    Bream, J.H.3
  • 37
    • 0030250114 scopus 로고    scopus 로고
    • Complex complexes: Signaling at the TCR
    • Wange RL, Samelson LE. Complex complexes: signaling at the TCR. Immunity. 1996;5:197-205.
    • (1996) Immunity , vol.5 , pp. 197-205
    • Wange, R.L.1    Samelson, L.E.2
  • 38
    • 0034129629 scopus 로고    scopus 로고
    • Signaling and transcription in T helper development
    • Murphy KM, Ouyang W, Farrar JD, et al. Signaling and transcription in T helper development. Annu Rev Immunol. 2000;18:451-494.
    • (2000) Annu Rev Immunol , vol.18 , pp. 451-494
    • Murphy, K.M.1    Ouyang, W.2    Farrar, J.D.3
  • 39
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-theta during T-cell activation
    • Monks CR, Kupfer H, Tamir I, Barlow A, Kupfer A. Selective modulation of protein kinase C-theta during T-cell activation. Nature. 1997;385:83-86.
    • (1997) Nature , vol.385 , pp. 83-86
    • Monks, C.R.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 40
    • 0032938157 scopus 로고    scopus 로고
    • Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: Proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction
    • Meller N, Elitzur Y, Isakov N. Protein kinase C-theta (PKCtheta) distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKCtheta in the particulate fraction. Cell Immunol. 1999;193:185-193.
    • (1999) Cell Immunol , vol.193 , pp. 185-193
    • Meller, N.1    Elitzur, Y.2    Isakov, N.3
  • 41
    • 0018933246 scopus 로고
    • Immune suppression of hematopoiesis in aplastic anemia: Activity of T-gamma lymphocytes
    • Bacigalupo A, Podesta M, Mingari MC, et al. Immune suppression of hematopoiesis in aplastic anemia: activity of T-gamma lymphocytes. J Immunol. 1980;125:1449-1453.
    • (1980) J Immunol , vol.125 , pp. 1449-1453
    • Bacigalupo, A.1    Podesta, M.2    Mingari, M.C.3
  • 42
    • 0036931853 scopus 로고    scopus 로고
    • T-bet as a possible therapeutic target in autoimmune disease
    • Weigmann B, Neurath MF. T-bet as a possible therapeutic target in autoimmune disease. Expert Opin Ther Targets. 2002;6:619-622.
    • (2002) Expert Opin Ther Targets , vol.6 , pp. 619-622
    • Weigmann, B.1    Neurath, M.F.2
  • 43
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002;195:1129-1143.
    • (2002) J Exp Med , vol.195 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 44
    • 0141860068 scopus 로고    scopus 로고
    • T-bet expression is upregulated in active Behcet's disease
    • Li B, Yang P, Zhou H, et al. T-bet expression is upregulated in active Behcet's disease. Br J Ophthalmol. 2003;87:1264-1267.
    • (2003) Br J Ophthalmol , vol.87 , pp. 1264-1267
    • Li, B.1    Yang, P.2    Zhou, H.3
  • 45
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • U S A
    • Peng SL, Szabo SJ, Glimcher LH. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A. 2002;99:5545-5550.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 5545-5550
    • Peng, S.L.1    Szabo, S.J.2    Glimcher, L.H.3
  • 46
    • 4344626455 scopus 로고    scopus 로고
    • Identification of a novel type 1 diabetes susceptibility gene, T-bet
    • Sasaki Y, Ihara K, Matsuura N, et al. Identification of a novel type 1 diabetes susceptibility gene, T-bet. Hum Genet. 2004;115:177-184.
    • (2004) Hum Genet , vol.115 , pp. 177-184
    • Sasaki, Y.1    Ihara, K.2    Matsuura, N.3
  • 48
    • 0037307394 scopus 로고    scopus 로고
    • The role of Tec family kinases in T cell development and function
    • Lucas JA, Miller AT, Atherly LO, Berg LJ. The role of Tec family kinases in T cell development and function. Immunol Rev. 2003;191:119-138.
    • (2003) Immunol Rev , vol.191 , pp. 119-138
    • Lucas, J.A.1    Miller, A.T.2    Atherly, L.O.3    Berg, L.J.4
  • 49
    • 0033597440 scopus 로고    scopus 로고
    • Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
    • Schaeffer EM, Debnath J, Yap G, et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999;284:638-641.
    • (1999) Science , vol.284 , pp. 638-641
    • Schaeffer, E.M.1    Debnath, J.2    Yap, G.3
  • 50
    • 19944431032 scopus 로고    scopus 로고
    • Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton
    • Dombroski D, Houghtling RA, Labno CM, et al. Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol. 2005;174:1385-1392.
    • (2005) J Immunol , vol.174 , pp. 1385-1392
    • Dombroski, D.1    Houghtling, R.A.2    Labno, C.M.3
  • 51
    • 10744228513 scopus 로고    scopus 로고
    • Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP
    • Labno CM, Lewis CM, You D, et al. Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol. 2003;13:1619-1624.
    • (2003) Curr Biol , vol.13 , pp. 1619-1624
    • Labno, C.M.1    Lewis, C.M.2    You, D.3
  • 52
    • 3142700652 scopus 로고    scopus 로고
    • Engagement of protein kinase C-theta in interferon signaling in T-cells
    • Srivastava KK, Batra S, Sassano A, et al. Engagement of protein kinase C-theta in interferon signaling in T-cells. J Biol Chem. 2004;279:29911-29920.
    • (2004) J Biol Chem , vol.279 , pp. 29911-29920
    • Srivastava, K.K.1    Batra, S.2    Sassano, A.3
  • 53
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005;5:521-531.
    • (2005) Nat Rev Immunol , vol.5 , pp. 521-531
    • Hunter, C.A.1
  • 54
    • 22144456041 scopus 로고    scopus 로고
    • The promise of molecular targeted therapies: Protein kinase inhibitors in the treatment of cutaneous malignancies
    • Kondapalli L, Soltani K, Lacouture ME. The promise of molecular targeted therapies: protein kinase inhibitors in the treatment of cutaneous malignancies. J AmAcad Dermatol. 2005;53:291-302.
    • (2005) J AmAcad Dermatol , vol.53 , pp. 291-302
    • Kondapalli, L.1    Soltani, K.2    Lacouture, M.E.3
  • 55
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med. 2005;353:172-187.
    • (2005) N Engl J Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2


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