On the role of methacrylic acid copolymers in the intracellular delivery of antisense oligonucleotides

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 1, 2006, Pages 1-10

  Yessine, Marie Andrée ^a   Meier, Christian ^b   Petereit, Hans Ulrich ^b   Leroux, Jean Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Rohm GmbH   (Germany)

Author keywords

Drug delivery; Endosomal release; Intracellular delivery; Methacrylic acid copolymers; Oligonucleotides

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COPOLYMER; LIPID; METHACRYLIC ACID; POLYELECTROLYTE; PROTEIN KINASE C ALPHA;

ACIDIFICATION; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CONFOCAL MICROSCOPY; CYTOPLASM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOSOME; FLUORESCENCE; HUMAN; HUMAN CELL; INCUBATION TIME; LUNG CARCINOMA; MACROMOLECULE; PH MEASUREMENT; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; ZETA POTENTIAL;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE, TUMOR; CELL NUCLEUS; CYTOPLASM; ENDOCYTOSIS; FATTY ACIDS, MONOUNSATURATED; FLOW CYTOMETRY; FLUORESCENT DYES; GENE SILENCING; HEMOLYSIS; HUMANS; LIPOSOMES; MICROSCOPY, CONFOCAL; MOLECULAR WEIGHT; OLIGONUCLEOTIDES, ANTISENSE; POLYMETHACRYLIC ACIDS; PROTEIN KINASE C-ALPHA; QUATERNARY AMMONIUM COMPOUNDS;

EID: 33646482849     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.10.010     Document Type: Article

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