Distinct clinicopathologic and genetic profiles in sporadic gastric cancer with different mutator phenotypes

Genes Chromosomes and Cancer

Volumn 27, Issue 4, 2000, Pages 403-411

  Wu, Ming Shiang ^a   Lee, Chung Wei ^a   Shun, Chia Tung ^a   Wang, Hsiu Po ^a   Lee, Wei Jei ^a   Chang, Ming Chu ^a   Sheu, Jin Chuan ^a   Lin, Jaw Town ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER;

CARRIER PROTEINS; DNA MUTATIONAL ANALYSIS; DNA-BINDING PROTEINS; FEMALE; GENES, P53; GENETIC MARKERS; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHENOTYPE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS; STOMACH NEOPLASMS;

EID: 0034006762     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(200004)27:4<403::AID-GCC10>3.0.CO;2-1     Document Type: Article

References (40)

1. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powel SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle. 1993. Clues to the pathogenesis of familial colorectal cancer. Science 260:812-816.
2. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. 1998. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72:141-196.
3. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani N, Srivastava S. 1998. A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58:5248-5257.
4. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JKV, Markowitz SD, Kinzler KW, Vogelstein B. 1998. Mutations of the mitotic checkpoint genes in human cancers. Nature 392:300-303.
5. Chung DC, Rustgi AK. 1995. DNA mismatch and cancer. Gastroenterology 109:1685-1699.
6. Chung YJ, Song JM, Lee JY, Jung YT, Seo EJ, Choi SW, Rhyu MG. 1996. Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. Cancer Res 56:4662-4665.
7. Cottu PH, Muzeau F, Estreicher A, Flejou JF, Iggo R, Thomas G, Hamelin R. 1996. Inverse correlation between RER+ status and P53 mutation in colorectal cell lines. Oncogene 13:2727-2730.
8. Cunningham JM, Christensen ER, Tester DJ, Kim CY, Roche PC, Burgart LJ, Thibodeau SN. 1998. Hypermethylation of the MLH1 promoter in colon cancer with microsatellite instability. Cancer Res 58:3455-3460.
9. Dietmaier W, Wallinger S, Bocker T, Kullmann F, Fishel R, Rushoff J. 1997. Diagnostic microsatellite instability: definition and correlation with mismatch repair expression. Cancer Res 57:4749-4756.
10. Dos Santos NR, Seruca R, Constancia M, Seixas M, Sobrinho-Simoes M. 1996. Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 110:38-14.
11. Eshleman JR, Markowitz SD. 1996. Mismath repair defects in human carcinogenesis. Hum Mol Genet 5:1489-1494.
12. Eshleman JR, Casey G, Kochera ME, Sedwick WD, Swinler SE, Veigl ML, Wilson JKV, Schwartz S, Markowitz SD. 1998. Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of P53. Oncogcne 17:719-725.
13. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ. 1999. Hypermethylation of the MLH1 gene promoter in human gastric cancer with microsatellite instability. Cancer Res 59:1090-1095.
14. Fuchs CS, Mayer RJ. 1995. Gastric carcinoma. N Engl J Med 333:32-41.
15. Fujiwara T, Stolker JM, Watanabe T, Rashid A, Longo P, Eshleman JR, Booker S, Lynch HT, Jass JR, Green JS, Kim H, Jen J, Vogelstein B, Hamilton SR. 1998. Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences. Am J Pathol 153:1063-1078.
16. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93:9821-9826.
17. Ikeda M, Orimo H, Moriyama H, Nakajima E, Matsubara N, Mibu R, Tanaka N, Shimada T, Kimura A, Shimizu K. 1998. Close correlation between mutations of E2F4 and MSH3 genes in colorectal cancer with microsatellite instability. Cancer Res 58-594-598.
18. Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup J, Kolodner R. 1997. Methylation of the MLH1 promoter correlates with lack of expression of MLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57:808-811.
19. Kim H, Jen J, Vogelstein B, Hamilton SR. 1994. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 145:148-156.
20. Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87:159-170.
21. Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M, Ushino K, Chiba M, Nomizu S, Konishi F, Utsunomiya J, Miyaki M. 1996. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 111:307-317.
22. Lauren P. 1965. The two histological main types of gastric carcinoma diffuse and so-called intestinal type carcinoma. Acta Pathol Microbiol Scand 64:31-49.
23. Leung SY, Yuen ST, Chung LP, Chu KM, Chan ASY, Ho JCI. 1999. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 59:159-164.
24. Lin JT, Wu MS, Shun CT, Lee WJ, Sheu JC, Wang TH. 1995. Occurrence of microsatellite instability in gastric cancer is associated with enhanced expression of erbB-2 oncoprotein. Cancer Res 55:1428-1430.
25. Loeb LA. 1991. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3079.
26. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom-Lahti M, Pylkkanen L, Heimdal K, Andersen TI, Moller P, Ragnum TO, Fossa SD, Haldorsen T, Langmark F, Brogger A, de la Chapelle A, Borresen A. 1993. Genomic instability in colorectal cancer: relationship to clinicopathologic variables and family history. Cancer Res 53:5849-5852.
27. Luinetti O. Fiocca R, Villani L, Alberizzi P, Ranzani GN, Solocia E. 1998. Genetic pattern, histologic structure, and cellular phenotype in early and advanced gastric cancers: evidence for structure-related genetic subsets and for loss of glandular structure during progression of some tumors. Hum Pathol 29:702-709.
28. Markowitz S, Wang J, Myeroff L, Parson R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV. 1995. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338.
29. Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J, Park K, Bang YJ, Lee HW, Park JG, Lynch HT, Roberts AB, Vogelstein B, Markowitz SD. 1995. A transforming growth factor β type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55:5545-5547.
30. Palombo F, Gallinari P, Iaccarino I, Lettieri T, Hughes M, D'Arrigo A, Truong O, Hsuan JJ, Jiricny J. 1995. GTB P, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science 268:1912-1914.
31. Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S. Willson JKV, Kinzler KW, Jiricny J, Vogelstein B. 1995. Mutations of GTBP in genetically unstable cells. Science 268:1915-1917.
32. Perucho M. 1996. Microsatellite instability: the mutator that mutates the other mutator. Nat Med 2:630-631.
33. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M. 1997. Somatic frameshift mutations in the BAX gene in colon cancer of the microsatellite mutator phenotype. Science 275:967-969.
34. Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J, Meltzer SJ. 1996. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumors. Nat Genet 14:255-257.
35. Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D. 1994. P53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res 54:4750-4755.
36. Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslein G, Baker SM, Liskay RM, Burgart JJ, Honchel R, Halling KC. 1996. Altered expression of MSH2 and MLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 56:4836-4840.
37. Yamamo H, Perez-Piteira J, Yoshida T, Terada M, Itoh F, Imai K, Perucho M. 1999. Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features. Gastroenterology 116:1348-1357.
38. Wu MS, Sheu JC, Shun CT, Lee WJ, Wang JT, Wang TH, Cheng AL, Lin JT 1997a. Infrequent MSH2 mutations in sporadic gastric adenocarcinoma with microsatellite instability. Cancer Lett 112: 161-166.
39. Wu MS, Shun CT, Wang HP, Sheu JC, Lee WJ, Wang TH, Lin JT. 1997b. Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage and Helicobacter pylori infection. Gastroenterology 112:1457-1465.
40. Wu MS, Lee CW, Shun CT, Wang Hp, Lee WJ, Sheu JC, Lin JT. 1998. Clinicopathological significance of altered loci of replication error and microsatellite-instability-associated mutations in gastric cancer. Cancer Res 58:1494-1497.