TGF-β-induced cell-cycle arrest through the p21(WAF1/CIP1)-G1 cyclin/CDKS-p130 pathway in gastric-carcinoma cells

International Journal of Cancer

Volumn 83, Issue 4, 1999, Pages 512-517

  Yoo, Young D ^a   Choi, Ju Youn ^a   Lee, Su Jae ^a   Kim, Jun S ^b   Min, Byung Re ^c   Lee, Young I ^d   Kang, Yoon Koo ^a  

^a Korea Cancer Center Hospital   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Sangmyung University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PROTEIN P21; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL CYCLE; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STOMACH CARCINOMA;

CARCINOMA; CELL CYCLE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; G1 PHASE; HUMANS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; UP-REGULATION;

EID: 0032852135     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19991112)83:4<512::AID-IJC13>3.0.CO;2-Z     Document Type: Article

References (24)

1. AKAGI, M., YASUI, W., AKAMA, Y., YOKOZAKI, H., TAMARA, H., HARUMA, K., KAJIYAMA, G. and TAMARA, E., Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric-carcinoma cells. Jap. J. Cancer Res., 87, 377-384 (1996).
2. CUI, W., FOWLIS, D.J., BRYSON, S., DUFFIE, E., IRELAND, H., BALMAIN, A. and AKHURST, R.J., TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell. 86, 531-542 (1996).
3. DATTO, M.B. and WANG, X.-F., Functional analysis of the transforming-growth-factor-beta-responsive elements in the WAF1/Cip1/p21 promoter. J. biol. Chem., 270, 28623-28628 (1995).
4. 1 arrest. Cell, 76, 1013-1024 (1994).
5. ELBENDARY, A., BERCHUCK, A., DAVIS, P., HAVRILESKY, L., BAST, R.C. JR., IGLEHART, J.D. and MARKS, J.R., Transforming growth factor beta I can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian-cancer cells. Cell Growth Differ., 5, 1301-1307 (1994).
6. EWEN, M.E., XING, Y.G., LAWRENCE, J.B. and LIVINGSTON, D.M., Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma-gene-product-related protein. Cell, 66, 1155-1164 (1991).
7. GARTENHAUS, R.B., WANG, P. and HOFFMANN, P., Induction of the WAF1/ CIP1 protein and apoptosis in human T-cell-leukemia-virus-type-I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway. Proc. nat. Acad Sci. (Wash.), 93, 265-268 (1996).
8. 1 cyclins and cyclin-dependent protein kinases. Proc. nat. Acad. Sci. (Wash.), 90, 10315-10319 (1993).
9. GOMYO, Y., IKEDA, M., OSAKI, M., TATEBE, S., TSUJITANI, S., IKEGUCHI, M., KAIBARA, N. and ITO, H., Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma. Cancer, 79, 2067-2072 (1997).
10. INK4B is a potential effector of TGF-β-induced cell-cycle arrest. Nature (Lond), 371, 257-261 (1994).
11. HERZINGER, T., WOLF, D.A., EICK, D. and KIND, P., The pRb-related protein p130 is a possible effector of transforming-growth-factor-β1-induced cell-cycle arrest in keratinocytes. Oncogene, 10, 2079-2084 (1995).
12. LAIHO, M., DECAPRIO, J.A., LUDLOW, J.W., LIVINGSTON, D.M. and MASSAGUÉ, J., Growth inhibition by TGF-β linked to suppression of retinoblastoma-protein phosphorylation. Cell, 62, 175-185 (1990).
13. LI, J.-M., Hu, P.P.-C., SHEN, X., Yu, Y. and WANG, X.-F., E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor β through E2F-binding sites. Proc. nat. Acad. Sci. (Wash.), 94, 4948-4953 (1997).
14. INK4B through an SpI consensus site. J. biol. Chem., 270, 26750-26753 (1995).
15. LI, Y., GRAHAM, C., LACY, S., DUNCAN, A.M.W. and WHYTE, P., The adenovirus-E1A-associated 130-kD protein is encoded by a member of the retinoblastoma-gene family and physically interacts with cyclins A and E. Genes Dev., 7, 2366-2377 (1993).
16. 0 lead to its association with E2F-4. Oncogene, 13, 237-246 (1996).
17. WAF1/CIP1 expression correlates with disease progression in gastric carcinoma. Brit. J. Cancer, 75, 1617-1620 (1997).
18. Cip1 in muscle and other terminally differentiating cells. Science, 267, 1024-1027 (1995).
19. PARK, K., KIM, S.-J., BANG, Y.-J., PARK, J.-G., KIM, N.K., ROBERTS, A.B. and SPORN, M.B., Genetic changes in the transforming-growth-factor-β (TGF-β)-type-II-receptor gene in human gastric-cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc. nat. Acad. Sci. (Wash.), 91, 8772-8776 (1994).
20. REYNISDOTTIR, I., POLYAK, K., IAVARONE, A. and MASSAGUÉ, J., Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell-cycle arrest in response to TGF-beta. Genes Dev., 9, 1831-1845 (1995).
21. ROBERTS, A.B. and SPORN, M.B., Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors, 8, 1-9 (1993).
22. WEINBERG, R.A., The retinoblastoma protein and cell-cycle control. Cell, 81, 323-330 (1995).
23. 1 arrest in gastric-cancer cells. Clin. Cancer Res., 4, 3063-3068 (1998).
24. YOO, Y.D., UEDA, H., PARK, K., FLANDERS, K.C., LEE, Y.I., JAY, G. and KIM, S.-J., Regulation of transforming-growth-factor-β1 expression by the hepatitis-B-virus (HBV)-X transactivator. J. clin. Invest., 97, 388-395 (1996).