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Volumn 6, Issue 4, 2006, Pages 779-782

Fast DNA sequencing via transverse electronic transport

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRONIC TRANSPORT; HUMAN GENOME; PARALLELIZATION; SINGLE-STRANDED DNA;

EID: 33646400831     PISSN: 15306984     EISSN: None     Source Type: Journal    
DOI: 10.1021/nl0601076     Document Type: Article
Times cited : (387)

References (44)
  • 24
    • 33646400532 scopus 로고    scopus 로고
    • note
    • We have used the program YAeHMOP (http://yaehmop.sourceforge.net/) to generate the tight-binding parameters used in this work. These parameters reproduce the states near the highest occupied and the lowest unoccupied molecular orbitals quite well compared to density-functional (DFT) calculations on the passivated nucleotide. In solution though, the nucleotides are charged. We have performed DFT calculations on charged nucleotides and found that the complex chemical environment with water molecules, counterions, and the gold electrodes passivates the charge on the nucleotides effectively. This finding allows us to use the same tight-binding parameters as in the passivated case. However, water only lowers the electrical current by a few percent on average, and its effect on the distributions is negligible. We will discuss these issues in more detail in a future publication.
  • 27
    • 33646390920 scopus 로고    scopus 로고
    • note
    • BTΔf)/R = 0.4 pA at room temperature. The effect of shot noise is comparable or less.
  • 28
    • 33646411463 scopus 로고    scopus 로고
    • note
    • These effects are also very important for charge transport in DNA along the longitudinal direction, see, for example
  • 29
  • 32
    • 33646416436 scopus 로고    scopus 로고
    • note
    • 32 were used for the interaction between the device itself and other elements.
  • 39
    • 33646437463 scopus 로고    scopus 로고
    • note
    • We stress again that for the conclusions of our paper we are only interested in the current of mutually opposite electrodes. In any case, the current between two neighboring electrodes would require inelastic scattering events, and hence is expected to be small.
  • 41
    • 33646391182 scopus 로고    scopus 로고
    • note
    • While collecting these distributions, the transverse field of strength 1.84 kcal/(mol Å e), which generates the current, is on during the molecular dynamics simulations. During a time span of 75 ps, we record 1500 values of the current. The switch-off of the driving field is dictated by the molecular dynamics time scales: we cannot slow the translocation to a regime accessible experimentally.
  • 44
    • 24044455869 scopus 로고    scopus 로고
    • Margulies, M. et al. Nature 2005, 437, 376.
    • (2005) Nature , vol.437 , pp. 376
    • Margulies, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.