Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations

Journal of Biological Chemistry

Volumn 281, Issue 12, 2006, Pages 8205-8215

  Yi, MinKyung ^a,b   Tong, Xiao ^c   Skelton, Angela ^c   Chase, Robert ^c   Chen, Tong ^c   Prongay, Andrew ^c   Bogen, Stephane L ^c   Saksena, Anil K ^c   George Njoroge, F ^c   Veselenak, Ronald L ^a,b   Pyles, Richard B ^a,b   Bourne, Nigel ^a,b   Malcolm, Bruce A ^c   Lemon, Stanley M ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DRUG THERAPY; GENES; MOLECULAR BIOLOGY; MUTAGENESIS; RNA; VIRUSES;

ANTIVIRAL THERAPIES; DRUG RESISTANCE; GENOTYPE; HEPATITIS C VIRUS; MUTATIONS;

ENZYME INHIBITION;

AMIDE; ANTIBIOTIC G 418; CILUPREVIR; INTERFERON; KETOAMIDE; NONSTRUCTURAL PROTEIN 3; POLYPROTEIN; PROTEINASE INHIBITOR; SCH 503034; SCH 6; UNCLASSIFIED DRUG; VIRUS RNA; VX 950; CARRIER PROTEIN; COMPLEMENTARY DNA; ENZYME INHIBITOR; NS3 PROTEIN, HEPATITIS C VIRUS; NS4A COFACTOR PEPTIDE, HEPATITIS C VIRUS; OLIGOPEPTIDE; RECOMBINANT PROTEIN; RNA; SCH6; VIRUS PROTEIN;

ARTICLE; CATALYSIS; CELL LINE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; GENOME; GENOTYPE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; REPLICON; RNA REPLICATION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; VIRUS MUTATION; VIRUS STRAIN; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG RESISTANCE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; IC 50; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

HEPATITIS C VIRUS;

BINDING SITES; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ENZYME INHIBITORS; GENETIC VECTORS; GENOTYPE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; OLIGOPEPTIDES; POLYPROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS;

EID: 33646369669     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510246200     Document Type: Article

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