Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps

Biochemistry

Volumn 45, Issue 17, 2006, Pages 5631-5640

  Tosha, Takehiko ^a   Kagawa, Norio ^b   Ohta, Takehiro ^a,c   Yoshioka, Shiro ^a,b   Waterman, Michael R ^b   Kitagawa, Teizo ^a  

^a OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CARBON MONOXIDE; CHEMICAL ACTIVATION; OXYGEN; PORPHYRINS; PURIFICATION; RAMAN SCATTERING; SUBSTRATES;

19-HYDROXYANDROSTENEDIONE; FERRIC PEROXO SPECIES; HUMAN CYTOCHROME P450 AROMATASE (P450AROM); PROXIMAL SITES;

ENZYMES;

19 HYDROXYANDROSTENEDIONE; ANDROSTENEDIONE; ANDROSTENEDIONE 19 ALDEHYDE; AROMATASE; HEME; IRON; OXYGEN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR STABILITY; PRIORITY JOURNAL; RAMAN SPECTROMETRY; REGULATORY MECHANISM;

ANDROSTENEDIONE; AROMATASE; CARBON MONOXIDE; FERROUS COMPOUNDS; HEME; HUMANS; MODELS, CHEMICAL; OXYGEN; SPECTROPHOTOMETRY; SPECTRUM ANALYSIS, RAMAN;

EID: 33646343223     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060094a     Document Type: Article

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