Role of 11-beta-hydroxysteroid dehydrogenase type 1 in differentiation of 3T3-L1 cells and in rats with diet-induced obesity

Acta Pharmacologica Sinica

Volumn 27, Issue 5, 2006, Pages 588-596

  Liu, Yun ^a   Sun, Wen Lan ^a   Sun, Yan ^a   Hu, Gang ^a   Ding, Guo Xian ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

11 beta hydroxysteroid dehydrogenase type 1; Adipocytes; Cell differentiation; Glucocorticoids; Obesity

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; BIOCHEMICAL MARKER; CHOLESTEROL; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; DIETARY INTAKE; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; MARKER GENE; NONHUMAN; OBESITY; PROADIPOCYTE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; CHOLESTEROL; FATTY ACID SYNTHETASE COMPLEX; INSULIN; LIPOPROTEIN LIPASE; MALE; MICE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; TRIGLYCERIDES;

EID: 33646258748     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00316.x     Document Type: Article

References (34)

1. Wake DJ Walker BR. 11beta-Hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome Mol Cell Endocrinol 2004 215 45 54
2. Kotelevtsev YV Holmes MC Burchell A. 11beta-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid inducible responses and resist hyperglycaemia on obesity or stress Proc Natl Acad Sci USA 1997 94 14924 9
3. Morton NM Holmes MC Fievet C. Improved lipid, lipoprotein profile, hepatic insulin sensitivity, and glucosetolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice J Biol Chem 2001 276 41293 300
4. Walker BR. beta-Hydroxysteroid dehydrogenase type 1 in obesity Obes Res 2004 12 1 3
5. Masuzaki H Paterson J Shinyama H Morton NM Mullins JJ Seckl J R et al. A transgenic model of visceral obesity and the metabolic syndrome Science 2001 294 2166 70
6. Masuzaki H Yamamoto H Kenyon CJ Elmquist JK Morton NM Paterson JM et al. Transgenic amplification of glucocor-ticoid action in adipose tissue causes high blood pressure in mice J Clin Invest 2003 112 83 90
7. Nicholas MM Lyner R Jonathan RS. Down-regulation of adipose 1 1beta-hydroxysteroid dehydrogenase type 1 by high-fat feeding in mice: a potential adaptive mechanism counteracting metabolic disease Endocrinology 2004 145 2707 12
8. Drake AJ Livingstone DE Andrew R Seckl JR Morton NM Walker BR. Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in wistar rats Endocrinology 2005 146 913 9
9. Reaven GM Hoffman BB. A role for insulin in the aetiology and course of hypertension Lancet 1987 2 435 7
10. Waldhäusl WK Roden MD. The effects of free fatty acids on glucose transport and phosphorylation in human skeletal muscle Curr Opin Endocrinol Metabol 2000 7 211 6
11. Felmer RN Clark JA. The gene suicide system ntr/cb1954 causes ablation of differentiated 3t311 adipocytes by apoptosis Biol Res 2004 37 449 60
12. Blagoev B Kratchmarova I Nielsen MM Fernandez M M Voldby J Andersen J S et al. Inhibition of adipocyte differentiation by resistin-like molecule alpha. Biochemical characterization of its oligomeric nature J Biol Chem 2002 277 42011 6
13. Sahai A Patel MS Zavosh AS Tannen RL. Chronic hypoxia impairs the differentiation of 3t3-11 fibroblast in culture: role of sustained protein kinase c activation J Cell Physiol 1994 160 107 12
14. Tomlinson JW Walker EA Bujalska IJ Draper N La very GG Cooper M S et al. 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response Endocr Rev 2004 25 831 66
15. Rabbitt EH Lavery GG Walker EA Cooper MS Stewart PM Hewison M. Prereceptor regulation of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation FASEB J 2002 16 36 44
16. Mangelsdorf DJ Thummel C Beato M Herrlich P Schutz G Umesono K et al. The nuclear receptor superfamily: the second decade Cell 1995 83 835 9
17. Reichardt HM Schutz G. Glucocorticoid signalling: multiple variations of a common theme Mol Cell Endocrinol 1998 146 1 6
18. Konig H Ponta H Rahmsdorf HJ Herrlich P. Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced ap-1 activity without altering ap-1 site occupation in vivo. EMBO J 1992 11 2241 6
19. Wei P Inamdar N Vedeckis WV. Transrepression of c-jun gene expression by the glucocorticoid receptor requires both ap-1 sites in the c-jun promoter Mol Endocrinol 1998 12 1322 33
20. Eijken M Hewison M Cooper MS de Jong FH Chiba H Stewart PM et al. 11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation Mol Endocrinol 2005 19 621 31
21. Bujalska IJ Walker EA Hewison M Stewart PM. A switch in dehydrogenase to reductase activity of 11 beta-hydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells J Clin Endocrinol Metab 2002 87 1205 10
22. Bujalska IJ Kumar S Hewison M Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 1 1beta-hydroxysteroid dehydrogenase Endocrinology 1999 140 3188 96
23. Draper N Walker EA Bujalska IJ Tomlinson JW Chalder SM Arlt W et al. Mutations in the genes encoding 1 1beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency Nat Genet 2003 34 434 9
24. Lindsay RS Wake DJ Nair S Bunt J Livingstone DE Permana PA et al. Subcutaneous adipose 11beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in pima Indians and Caucasians J Clin Endocrinol Metab 2003 88 2738 44
25. Engeli S Bohnke J Feldpausch M Gorzelniak K Heintze U Janke J et al. Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss Obes Res 2004 12 9 17
26. Draper N Echeald SM Lavery GG. Association studies between microsatellite markers within the gene encoding human 11 beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism J Clin Endocrinol Metab 2002 87 4984 90
27. Kotelevtsev Y Holmes MC Burchell A Houston PM Schmoll D Jamieson P et al. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress Proc Natl Acad Sci USA 1997 94 14924 9
28. Asensio C Muzzin P Rohner-Jeanrenaud F. Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance Int J Obes Relat Metab Disord 2004 28 Suppl 4 S45 52
29. DeFronzo RA Ferrannini E. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease Diabetes Care 1991 14 173 94
30. Whorwood CB Donovan SJ Flanagan D Phillips DI Byrne CD. Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome Diabetes 2002 51 1066 75
31. Velkoska E Cole TJ Morris MJ. Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers Am J Physiol Endocrinol Metab 2005 288 E1236 43
32. Seckl JR Walker BR. Minireview: 11beta-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action Endocrinology 2001 142 1371 6
33. Yau JL Noble J Kenyon CJ Hibberd C Kotelevtsev Y Mullins JJ et al. Lack of tissue glucocorticoid reactivation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments Proc Natl Acad Sci USA 2001 98 4716 21
34. Seckl JR Dow RC Low SC Edwards CR Fink G. The 11beta-hydroxysteroid dehydrogenase inhibitor glycyrrhetinic acid affects corticosteroid feedback regulation of hypothalamic corticotrophin-releasing peptides in rats J Endocrinol 1993 136 471 7