Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome

Diabetes

Volumn 51, Issue 4, 2002, Pages 1066-1075

  Trost, Susanne U ^a   Belke, Darrell D ^a   Bluhm, Wolfgang F ^a   Meyer, Markus ^a   Swanson, Eric ^a   Dillmann, Wolfgang H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOSE; HYDROCORTISONE; INSULIN; MIFEPRISTONE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY FAT; BODY MASS; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; METABOLIC DISORDER; MUSCLE CELL; MYOBLAST; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SKELETAL MUSCLE;

EID: 0036230286     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.4.1066     Document Type: Article

References (45)

1. Do non-insulin-dependent diabetes mellitus and cardiovascular disease share common antecedents?
2. Lilly lecture 1987: The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM
3. Role of insulin resistance in human disease
4. Neuroendocrine abnormalities in human obesity
5. Genetic and nongenetic determinants of regional fat distribution
6. Endocrine aspects of obesity
7. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
8. Intracellular glucose oxidation and glycogen synthase activity are reduced in noninsulin-dependent (type II) diabetes independent of impaired glucose uptake
9. Insulin action and glucose metabolism in non-diabetic control and NIDDM subjects: Comparison using human skeletal muscle cell cultures
10. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: Biochemical and molecular mechanisms
11. Role of glucocorticoids and fatty acids in the impairment of lipid metabolism observed in the metabolic syndrome
12. Glucocorticoids and insulin resistance: Old hormones, new targets
13. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism in rat skeletal muscle
14. Control of glycaemia
15. The effect of cortisol on glucose/glucose-6-phospate cycle activity and insulin action
16. Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells
17. Elevated plasma cortisol concentrations: A link between low birthweight and the insulin resistance syndrome?
18. Hyper-activity of the hypothalamic-pituitary-adrenal axis may mediate the link between impaired fetal growth and the insulin resistance syndrome
19. Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males
20. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus
21. Primary cortisol resistance accompanied by a reduction in glucocorticoid receptors in two members of the same family
22. A patient with hypocortisolism and Cushing's syndrome-like manifestations: Cortisol hyperreactive syndrome
23. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
24. 11β-hydroxysteroid dehydrogenase
25. The human glucocorticoid receptor β isoform
26. Inreased glucocorticoid activity in men with cardiovacular risk factors
27. Does central obesity reflect "Cushing's disease of the omentum"?
28. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
29. Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity
30. 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity and stress
31. Regulation of glucocorticoid receptor isoforms and 11β-hydroxysteroid dehydrogenase in human skeletal muscle
32. Insulin action in cultured human myoblasts: Contribution of different signalling pathways to regulation of glycogen synthesis
33. Epithelial cell localisation of type 2 11β hydroxysteroid dehydrogenase in rat and human colon
34. Detection of human 11β hydroxysteroid dehydrogenase isoforms using reverse-transciptase-polymerase chain reaction and localisation of the type 2 isoform to renal collecting ducts
35. Primary structure and expression of a functional human glucocorticoid receptor cDNA
36. The human gene for 11β-hydroxysteroid dehydrogenase: Structure, tissue distribution, and chromosomal localization
37. The nucleotide sequence of a rat 18S ribosomal ribonucleic acid gene and a proposal of the secondary structure of 18S ribosomal ribonucleic acid
38. Evaluation of the role of ligand and thermal activation on specific DNA binding by in vitro synthesized human glucocorticoid receptor
39. Regulation of glucocorticoid receptor (GR) α and β by cytokines and glucocorticoids in skeletal myocytes from men with contrasting levels of insulin resistance and obesity
40. Glucocorticoids induced down-regulation of glucocorticoid receptor mRNA expression in asthma
41. Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
42. Tumour necrosis factor α and interleukin 1β enhance the cortisone/cortisol shuttle
43. Elevated serum tumor necrosis factor-alpha levels can contribute to the insulin resistance in type II (non-insulin-dependent) diabetes and in obesity
44. The expression of TNF by human muscle: Relationship to insulin resistance
45. Glucocorticiod receptor messenger ribonucleic acid in different regions of human adipose tissue