Transrepression of c-jun Gene Expression by the Glucocorticoid Receptor Requires Both AP-1 Sites in the c-jun Promoter

Molecular Endocrinology

Volumn 12, Issue 9, 1998, Pages 1322-1333

  Wei, Ping ^a   Inamdar, Nilufar ^a   Vedeckis, Wayne V ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL; ARTICLE; BINDING SITE; CELL CULTURE; DOWN REGULATION; DRUG EFFECT; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; ONCOGENE; PROMOTER REGION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CELLS, CULTURED; DEXAMETHASONE; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENES, JUN; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS; RNA, MESSENGER; SEQUENCE DELETION; TRANSCRIPTION FACTOR AP-1;

EID: 0032161917     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.9.0158     Document Type: Article

References (61)

1. Curran T, Franza Jr BR 1988 Fos and Jun: the AP-1 connection. Cell 55 55:395-397
2. Angel P, Karin M 1991 The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129-157
3. Quantin B, Breathnach R 1988 Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature 334:538-539
4. 1 transition in mouse fibroblasts. Nature 334:535-537
5. Angel P, Hattori K, Smeal T, Karin M 1988 The jun protooncogene is positively autoregulated by its product, Jun/ AP-1. Cell 55:875-885
6. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M 1989 Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature 337:661-663
7. van Dam H, Offringa R, Meijer I, Stein B, Smits AM, Herrlich P, Bos JL, van der Eb AJ 1990 Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family. Mol Cell Biol 10: 5857-5864
8. Devary Y, Gottlieb RA, Lau LF, Karin M 1991 Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11:2804-2811
9. Vig E, Barrett TJ, Vedeckis WV 1994 Coordinate regulation of the glucocorticoid receptor and c-jun mRNA levels: evidence for cross-talk between two signaling pathways at the transcriptional level. Mol Endocrinol 8:1336-1346
10. Barrett TJ, Vedeckis WV 1996 Coordinate regulation of glucocorticoid and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down- and up-regulation. Biochemistry 35:9746-9753
11. Lee H, Shaw Y-T, Chiou S-T, Chang W-C, Lai M-D 1991 The effects of glucocorticoid hormone on the expression of c-jun. FEBS Lett 280:134-136
12. Stein B, Angel P, van Dam H, Ponta H, Herrlich P, van der Eb A, Rahmsdorf HJ 1992 Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. Photochem Photobiol 55:409-415
13. van Dam H, Duyndam M, Rottier R, Bosch A, de Vries-Smits L, Herrlich P, Zantema A, Angel P, van der Eb AJ 1993 Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J 12:479-487
14. Cato AC, Ponta H, Herrlich P 1992 Regulation of gene expression by steroid hormones. Prog Nucleic Acid Res Mol Biol 43:1-36
15. Ponta H, Cato ACB, Herrlich P 1992 Interference of pathway specific transcription factors. Biochim Biophys Acta 1129:255-261
16. Lamph WW, Wamsley P, Sassone-Corsi P, Verma IM 1988 Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature 334:629-631
17. Herschman HR 1991 Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281-319
18. Kovary K, Bravo R 1991 The Jun and Fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol 9:4466-4472
19. Meyuhas O, Perry RP 1980 Construction and identification of cDNA clones for mouse ribosomal proteins: application for the study of r-protein gene expression. Gene 10 10:113-129
20. Hattori K, Angel P, Le Beau MM, Karin K 1988 Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci USA 85:9148-9152
21. Unlap T, Franklin CC, Wagner F, Kraft AS 1992 Upstream regions of the c-jun promoter regulate phorbol ester-induced transcription in U937 leukemic cells. Nucleic Acids Res 20:897-902
22. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M 1987 Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739
23. Housley PR, Forshoefel AM 1989 Isolation and characterization of a mouse L cell variant deficient in glucocorticoid receptors. Biochem Biophys Res Commun 164: 480-487
24. Gossen M, Bujard H 1992 Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551
25. Wei P, Ahn YI, Housley PR, Alam J, Vedeckis WV 1998 Modulation of hormone-dependent glucocorticoid receptor function using a tetracycline-regulated expression system. J Steroid Biochem Mol Biol 64:1-12
26. Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P 1990 Antitumor promotion and anti-inflamation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62:1189-1204
27. Lucibello FC, Slater EP, Jooss KU, Beato M, Muller R 1990 Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO J 9:2827-2834
28. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans RM 1990 Functional antagonism between the oncoprotein c-jun and the glucocorticoid receptor. Cell 62:1217-1226
29. Yang-Yen HF, Chambard JC, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M 1990 Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215
30. Shemshedini L, Knauthe R, Sassone-Corsi P, Pornon A, Gronemeyer H 1991 Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors. EMBO J 10:3839-3849
31. Kerppola TK, Luk D, Curran T 1993 Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro. Mol Cell Biol 13:3782-3791
32. Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, Cato AC 1994 A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13:4087-4095
33. A gene. Nature 308:513-519
34. Mordacq JC, Linzer DIH 1989 Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes Dev 3:760-769
35. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR 1990 Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272
36. Zhou F, Thompson EB 1996 Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts. Mol Endocrinol 10:306-316
37. Brinckerhoff CE, Plucinska IM, Sheldon LA, O'Connor GT 1986 Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone. Biochemistry 25:6378-6384
38. Frisch SM, Ruley HE 1987 Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone. J Biol Chem 262:3535-3542
39. Muller D, Quantin B, Gesnel M-C, Millon-Collard R, Abecasis J, Breathnach R 1988 The collagenase gene family in humans consists of at least four members. Biochem J 235:187-192
40. Whitham SE, Murphy G, Angel P, Rahmsdorf HJ, Smith BJ, Lyons A, Harris TJ, Reynolds JJ, Herrlich P, Docherty AP 1988 Comparisons of human stromelysin and collagenase genes by cloning and sequence analysis. Biochem J 240:913-916
41. Breslin MB, Vedeckis WV 1996 The glucocorticoid receptor and c-jun promoters contain AP-1 sites that bind different AP-1 transcription factors. Endocrine 5:15-22
42. Wei P, Vedeckis WV 1997 Regulation of the glucocorticoid receptor gene by the AP-1 transcription factor. Endocrine 7:303-310
43. Hadman M, Loo M, Bos TJ 1993 In vivo viral and cellular Jun complexes exhibit differential interactions with a number of in vitro generated "AP-1 and CREB-like" target sequences. Oncogene 8:1895-1903
44. Herr I, van Dam H, Angel P 1994 Binding of promoter-associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation. Carcinogenesis 15:1105-1113
45. Rozek D, Pfeifer GP 1995 In vivo protein-DNA interactions at the c-jun promoter in quiescent and serum-stimulated fibroblasts. J Cell Biochem 57:479-487
46. König H, Ponta H, Rahmsdorf HJ, Herrlich P 1992 Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO J 11:2241-2246
47. Barrett TJ, Vedeckis WV 1996 Occupancy and composition of proteins bound to the AP-1 sites in the glucocorticoid and c-jun promoters after glucocorticoid treatment and in different cell types. Receptors Signal Transduction 6:179-193
48. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG 1996 A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414
49. Ruhmann AG, Berliner DL 1965 Effect of steroids on growth of mouse fibroblasts in vitro. Endocrinology 76:916-927
50. Hackney JF, Gross SR, Aronow L, Pratt WB 1970 Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. Mol Pharmacol 6:500-512
51. Kelly W, Harris Jr E, Ruddy S, Sledge C 1985 Textbook of Rheumatology. WB Saunders Co, Philadelphia
52. Gilman AG, Goodman LS, Rail TW, Murad F 1985 Goodman and Gilman's The Pharmacological Basis of Therapeutics. Macmillan Publishing, New York
53. Ryder K, Nathans D 1988 Induction of protooncogene c-jun by serum growth-factors. Proc Natl Acad Sci USA 85:8464-8467
54. 1 and S. Oncogene 6:229-235
55. 1 transition in mouse fibroblasts: in vitro and in vivo associations. Mol Cell Biol 11:2451-2459
56. Smith MJ, Prochownik EV 1992 Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle. Blood 79:2107-2115
57. Berko-Flint Y, Levkowitz G, Vardimon L 1994 Involvement of c-Jun in the control of glucocorticoid receptor transcriptional activity during development of chicken retinal tissue. EMBO J 13:646-654
58. Jain V, Magrath I 1991 A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: application to quantitation of β-galactosidase in lacZ-transfected cells. Anal Biochem 199:119-124
59. Graham FL, van der Eb AJ 1973 A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-457
60. Gametchu B, Harrison RW 1984 Characterization of a monoclonal antibody to the rat liver glucocorticoid receptor. Endocrinology 114:274-279
61. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual, ed. 2. Cold Spring Harbor Press, Cold Spring Harbor, NY