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Volumn 90, Issue 3, 2006, Pages 799-810

An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR; WATER;

EID: 33646187879     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.067868     Document Type: Article
Times cited : (62)

References (44)
  • 1
    • 0029593370 scopus 로고
    • Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
    • Karlin, A., and M. H. Akabas. 1995. Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron. 15:1231-1244.
    • (1995) Neuron. , vol.15 , pp. 1231-1244
    • Karlin, A.1    Akabas, M.H.2
  • 2
    • 0036480194 scopus 로고    scopus 로고
    • Emerging structure of the nicotinic acetylcholine receptors
    • Karlin, A. 2002. Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3:102-114.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 102-114
    • Karlin, A.1
  • 3
    • 1642383081 scopus 로고    scopus 로고
    • Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure
    • Absalom, N. L., T. M. Lewis, and P. R. Scholfield. 2004. Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure. Exp. Physiol. 89:145-153.
    • (2004) Exp. Physiol. , vol.89 , pp. 145-153
    • Absalom, N.L.1    Lewis, T.M.2    Scholfield, P.R.3
  • 4
    • 0025678678 scopus 로고
    • Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction
    • Toyoshima, C., and N. Unwin. 1990. Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction. J. Cell Biol. 111:2623-2635.
    • (1990) J. Cell Biol. , vol.111 , pp. 2623-2635
    • Toyoshima, C.1    Unwin, N.2
  • 5
    • 0027506299 scopus 로고
    • Nicotinic acetylcholine receptor at 9 Å resolution
    • Unwin, N. 1993. Nicotinic acetylcholine receptor at 9 Å resolution. J. Mol. Biol. 229:1101-1124.
    • (1993) J. Mol. Biol. , vol.229 , pp. 1101-1124
    • Unwin, N.1
  • 6
    • 0027057058 scopus 로고
    • The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis
    • Changeux, J. P., J. I. Galzi, A. Devillers-Thiry, and D. Bertrand. 1992. The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis. Q. Rev. Biophys. 25:395-432.
    • (1992) Q. Rev. Biophys. , vol.25 , pp. 395-432
    • Changeux, J.P.1    Galzi, J.I.2    Devillers-Thiry, A.3    Bertrand, D.4
  • 7
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca, C., M. W. Nowak, H. Zhang, L. Tang, P. Deshpande, and H. A. Lester. 1995. Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature. 376:514-516.
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 9
    • 0026684455 scopus 로고
    • The permeation pathway of neurotransmitter-gated ion channels
    • Lester, H. 1992. The permeation pathway of neurotransmitter-gated ion channels. Annu. Rev. Biophys. Biomol. Struct. 21:267-292.
    • (1992) Annu. Rev. Biophys. Biomol. Struct. , vol.21 , pp. 267-292
    • Lester, H.1
  • 10
    • 0028921479 scopus 로고
    • Acetylcholine receptor channel imaged in the open state
    • Unwin, N. 1995. Acetylcholine receptor channel imaged in the open state. Nature. 373:37-43.
    • (1995) Nature , vol.373 , pp. 37-43
    • Unwin, N.1
  • 11
    • 0038112088 scopus 로고    scopus 로고
    • Structure and gating mechanism of the acetylcholine receptor pore
    • Miyazawa, A., Y. Fujiyoshi, and N. Unwin. 2003. Structure and gating mechanism of the acetylcholine receptor pore. Nature. 423:949-955.
    • (2003) Nature , vol.423 , pp. 949-955
    • Miyazawa, A.1    Fujiyoshi, Y.2    Unwin, N.3
  • 12
    • 13444271681 scopus 로고    scopus 로고
    • Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
    • Unwin, N. 2005. Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution. J. Mol. Biol. 346:967-989.
    • (2005) J. Mol. Biol. , vol.346 , pp. 967-989
    • Unwin, N.1
  • 14
    • 0034677524 scopus 로고    scopus 로고
    • Mapping the conformational wave of acetylcholine receptor channel gating
    • Grosman, C., M. Zhou, and A. Auerbach. 2000. Mapping the conformational wave of acetylcholine receptor channel gating. Nature. 403:773-776.
    • (2000) Nature , vol.403 , pp. 773-776
    • Grosman, C.1    Zhou, M.2    Auerbach, A.3
  • 15
    • 0037197654 scopus 로고    scopus 로고
    • Structure of the transition state of gating in the acetylcholine receptor channel pore: A phi-value analysis
    • Cymes, G. D., C. Grosman, and A. Auerbach. 2002. Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry. 41:5548-5555.
    • (2002) Biochemistry , vol.41 , pp. 5548-5555
    • Cymes, G.D.1    Grosman, C.2    Auerbach, A.3
  • 17
    • 0029123899 scopus 로고
    • The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
    • Filatov, G. N., and M. M. White. 1995. The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating. Mol. Pharmacol. 48:379-384.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 379-384
    • Filatov, G.N.1    White, M.M.2
  • 18
    • 0032102496 scopus 로고    scopus 로고
    • The location of the gate in the acetylcholine receptor channel
    • Wilson, G. G., and A. Karlin. 1998. The location of the gate in the acetylcholine receptor channel. Neuron. 20:1269-1281.
    • (1998) Neuron. , vol.20 , pp. 1269-1281
    • Wilson, G.G.1    Karlin, A.2
  • 19
    • 0031781630 scopus 로고    scopus 로고
    • State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor: Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit
    • Pascual, J. M., and A. Karlin. 1998. State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor: inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit. J. Gen. Physiol. 111:717-739.
    • (1998) J. Gen. Physiol. , vol.111 , pp. 717-739
    • Pascual, J.M.1    Karlin, A.2
  • 20
    • 33748573642 scopus 로고    scopus 로고
    • The influence of geometry, surface character, and flexibility on the permeation of ions through biological pores
    • Beckstein, O., and M. S. P. Sansom. 2004. The influence of geometry, surface character, and flexibility on the permeation of ions through biological pores. Phys. Biol. 1:42-52.
    • (2004) Phys. Biol. , vol.1 , pp. 42-52
    • Beckstein, O.1    Sansom, M.S.P.2
  • 21
    • 2442548865 scopus 로고    scopus 로고
    • Theoretical conformation of the closed and open states of the acetylcholine receptor channel
    • Corry, B. 2004. Theoretical conformation of the closed and open states of the acetylcholine receptor channel. Biochim. Biophys. Acta. 1663:2-5.
    • (2004) Biochim. Biophys. Acta , vol.1663 , pp. 2-5
    • Corry, B.1
  • 22
    • 2142715470 scopus 로고    scopus 로고
    • Water dynamics and dewetting transitions in the small mechanosensitive channel MscS
    • Anishkin, A., and S. Sukharev. 2004. Water dynamics and dewetting transitions in the small mechanosensitive channel MscS. Biophys. J. 86:2883-2895.
    • (2004) Biophys. J. , vol.86 , pp. 2883-2895
    • Anishkin, A.1    Sukharev, S.2
  • 23
    • 13544256698 scopus 로고    scopus 로고
    • Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS
    • Sotomayor, M., and K. Schulten. 2004. Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS. Biophys. J. 87:3050-3065.
    • (2004) Biophys. J. , vol.87 , pp. 3050-3065
    • Sotomayor, M.1    Schulten, K.2
  • 24
    • 0033813781 scopus 로고    scopus 로고
    • The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel
    • Wilson, G. G., J. M. Pascual, N. Brooijmans, D. Murray, and A. Karlin. 2000. The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel. J. Gen. Physiol. 115:93-106.
    • (2000) J. Gen. Physiol. , vol.115 , pp. 93-106
    • Wilson, G.G.1    Pascual, J.M.2    Brooijmans, N.3    Murray, D.4    Karlin, A.5
  • 25
    • 13644270375 scopus 로고    scopus 로고
    • Conformational dynamics of the nicotinic acetylcholine receptor channel: A 35-ns molecular dynamics simulation study
    • Xu, Y., F. J. Barrantes, X. Luo, K. Chen, J. Shen, and H. Jiang. 2005. Conformational dynamics of the nicotinic acetylcholine receptor channel: a 35-ns molecular dynamics simulation study. J. Am. Chem. Soc. 127:1291-1299.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 1291-1299
    • Xu, Y.1    Barrantes, F.J.2    Luo, X.3    Chen, K.4    Shen, J.5    Jiang, H.6
  • 26
    • 21244436322 scopus 로고    scopus 로고
    • The transmembrane domain of the acetylcholine receptor: Insights from simulations and synthetic peptide models
    • Saiz, L., and M. L. Klein. 2005. The transmembrane domain of the acetylcholine receptor: insights from simulations and synthetic peptide models. Biophys. J. 88:959-970.
    • (2005) Biophys. J. , vol.88 , pp. 959-970
    • Saiz, L.1    Klein, M.L.2
  • 27
    • 21244436719 scopus 로고    scopus 로고
    • Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor
    • Saladino, A. C., Y. Xu, and P. Tang. 2005. Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor. Biophys. J. 88:1009-1017.
    • (2005) Biophys. J. , vol.88 , pp. 1009-1017
    • Saladino, A.C.1    Xu, Y.2    Tang, P.3
  • 28
    • 17844364634 scopus 로고    scopus 로고
    • Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: Structure and collective motions
    • Hung, A., K. Tai, and M. S. P. Sansom. 2005. Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions. Biophys. J. 88:3321-3333.
    • (2005) Biophys. J. , vol.88 , pp. 3321-3333
    • Hung, A.1    Tai, K.2    Sansom, M.S.P.3
  • 29
    • 18744363916 scopus 로고    scopus 로고
    • A gating mechanism proposed from a simulation of a human 7 nicotinic acetylcholine receptor
    • Law, R. J., R. H. Henchman, and J. A. McCammon. 2005. A gating mechanism proposed from a simulation of a human 7 nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA. 102:6813-6818.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 6813-6818
    • Law, R.J.1    Henchman, R.H.2    McCammon, J.A.3
  • 32
    • 0030404988 scopus 로고    scopus 로고
    • Hole: A program for the analysis of the pore dimensions of ion channel structural models
    • Smart, O. S., J. G. Neduvelil, X. Wang, B. A. Wallace, and M. S. P. Sansom. 1996. Hole: a program for the analysis of the pore dimensions of ion channel structural models. J. Mol. Graph. 14:354-360.
    • (1996) J. Mol. Graph. , vol.14 , pp. 354-360
    • Smart, O.S.1    Neduvelil, J.G.2    Wang, X.3    Wallace, B.A.4    Sansom, M.S.P.5
  • 33
    • 0002786541 scopus 로고    scopus 로고
    • Brownian dynamics study of ion transport in the vestibule of membrane channels
    • Li, S. C., M. Hoyles, S. Kuyucak, and S. H. Chung. 1998. Brownian dynamics study of ion transport in the vestibule of membrane channels. Biophys. J. 74:37-47.
    • (1998) Biophys. J. , vol.74 , pp. 37-47
    • Li, S.C.1    Hoyles, M.2    Kuyucak, S.3    Chung, S.H.4
  • 34
    • 0036151669 scopus 로고    scopus 로고
    • Conducting state properties of the KcsA potassium channel from molecular and Brownian dynamics simulations
    • Chung, S. H., T. W. Allen, and S. Kuyucak. 2002. Conducting state properties of the KcsA potassium channel from molecular and Brownian dynamics simulations. Biophys. J. 82:628-645.
    • (2002) Biophys. J. , vol.82 , pp. 628-645
    • Chung, S.H.1    Allen, T.W.2    Kuyucak, S.3
  • 35
    • 0035132981 scopus 로고    scopus 로고
    • Mechanisms of permeation and selectivity in calcium channels
    • Corry, B., T. W. Allen, S. Kuyucak, and S. H. Chung. 2001. Mechanisms of permeation and selectivity in calcium channels. Biophys. J. 80:195-214.
    • (2001) Biophys. J. , vol.80 , pp. 195-214
    • Corry, B.1    Allen, T.W.2    Kuyucak, S.3    Chung, S.H.4
  • 36
    • 0035575826 scopus 로고    scopus 로고
    • Brownian dynamics study of an open-state KcsA potassium channel
    • Allen, T. W., and S. H. Chung. 2001. Brownian dynamics study of an open-state KcsA potassium channel. Biochim. Biophys. Acta. 1515:83-91.
    • (2001) Biochim. Biophys. Acta , vol.1515 , pp. 83-91
    • Allen, T.W.1    Chung, S.H.2
  • 37
    • 0036213027 scopus 로고    scopus 로고
    • Reservoir boundaries in Brownian dynamics simulations of ion channels
    • Corry, B., M. Hoyles, T. W. Allen, M. Walker, S. Kuyucak, and S. H. Chung. 2002. reservoir boundaries in Brownian dynamics simulations of ion channels. Biophys. J. 82:1975-1982.
    • (2002) Biophys. J. , vol.82 , pp. 1975-1982
    • Corry, B.1    Hoyles, M.2    Allen, T.W.3    Walker, M.4    Kuyucak, S.5    Chung, S.H.6
  • 38
    • 0035902009 scopus 로고    scopus 로고
    • Crystal structure of an Achbinding protein reveals the ligand binding domain of nicotinic receptors
    • Brejc, K., W. J. van Dijk, R. V. Klaassen, M. Schuurmans, J. van Der Oost, A. B. Smit, T. K. Sixma. 2001. Crystal structure of an Achbinding protein reveals the ligand binding domain of nicotinic receptors. Nature. 411:269-276.
    • (2001) Nature , vol.411 , pp. 269-276
    • Brejc, K.1    Van Dijk, W.J.2    Klaassen, R.V.3    Schuurmans, M.4    Van Der Oost, J.5    Smit, A.B.6    Sixma, T.K.7
  • 39
    • 0032158469 scopus 로고    scopus 로고
    • Computer simulation of ion conductance in membrane channels
    • Hoyles, M., S. Kuyucak, and S. H. Chung. 1998. Computer simulation of ion conductance in membrane channels. Phys. Rev. E. 58:3654-3661.
    • (1998) Phys. Rev. E , vol.58 , pp. 3654-3661
    • Hoyles, M.1    Kuyucak, S.2    Chung, S.H.3
  • 40
    • 0036040016 scopus 로고    scopus 로고
    • Linear free-energy relationships and the dynamics of gating in the acetylcholine receptor channel: A phi-value analysis of an allosteric transition at the single-molecule level
    • Grosman, C. 2002. Linear free-energy relationships and the dynamics of gating in the acetylcholine receptor channel: a phi-value analysis of an allosteric transition at the single-molecule level. J. Biol. Phys. 28:267-277.
    • (2002) J. Biol. Phys. , vol.28 , pp. 267-277
    • Grosman, C.1
  • 41
    • 0019820754 scopus 로고
    • Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells
    • Hamill, O. P., and B. Sakmann. 1981. Multiple conductance states of single acetylcholine receptor channels in embryonic muscle cells. Nature. 294:462-464.
    • (1981) Nature , vol.294 , pp. 462-464
    • Hamill, O.P.1    Sakmann, B.2
  • 42
    • 0001736094 scopus 로고
    • Perfection of a synaptic receptor: Kinetics and energetics of the acetylcholine receptor
    • Jackson, M. B. 1982. Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor. Proc. Natl. Acad. Sci. USA. 86:2199-2203.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2199-2203
    • Jackson, M.B.1
  • 43
    • 0035961071 scopus 로고    scopus 로고
    • A hydrophobic gating mechanism for nanopores
    • Beckstein, O., P. C. Biggin, and M. S. P. Sansom. 2001. A hydrophobic gating mechanism for nanopores. J. Phys. Chem. B. 105:12902-12905.
    • (2001) J. Phys. Chem. B , vol.105 , pp. 12902-12905
    • Beckstein, O.1    Biggin, P.C.2    Sansom, M.S.P.3
  • 44
    • 0038472282 scopus 로고    scopus 로고
    • Liquid-vapor oscillations of water in hydrophobic nanopores
    • Beckstein, O., and M. S. P. Sansom. 2003. Liquid-vapor oscillations of water in hydrophobic nanopores. Proc. Natl. Acad. Sci. USA. 100:7063-7068.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7063-7068
    • Beckstein, O.1    Sansom, M.S.P.2


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