Brownian dynamics study of ion transport in the vestibule of membrane channels

Biophysical Journal

Volumn 74, Issue 1, 1998, Pages 37-47

  Li, Siu Cheung ^a   Hoyles, Matthew ^a   Kuyucak, Serdar ^a   Chung, Shin Ho ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CALCULATION; ELECTRIC POTENTIAL; ION TRANSPORT; MEMBRANE CHANNEL; MEMBRANE POTENTIAL; PROTEIN BINDING; VESTIBULE;

EID: 0002786541     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(98)77764-1     Document Type: Article

References (21)

1. Bek, S., and E. Jakobsson. 1994. Brownian dynamics study of a multiply occupied cation channel: application to understanding permeation in potassium channel. Biophys. J. 66:1028-1038.
2. Chen, D., J. Lear, and R. Eisenberg. 1997. Permeation through an open channel: Poisson-Nernst-Planck theory of a synthetic ion channel. Biophys. J. 72:97-116.
3. Chiu, S.-W., and E. Jakobsson. 1989. Stochastic theory of singly occupied ion channels. II. Effects of access resistance and potential gradients extending into the bath. Biophys. J. 55:147-157.
4. Chiu, S.-W., S. Subramaniam, E. Jakobsson, and J. A. McCammon. 1989. Water and polypeptide conformations in the gramicidin channel. Biophys. J. 56:253-261.
5. Chung, S. H., and S. Kuyucak. 1995. Temperature-dependent changes in the characteristics of NMDA-activated channels in hippocampal neurons. Neurosci. Lett. 187:181-184.
6. Cooper, K., E. Jakobsson, and P. Wolynes. 1985. The theory of ion transport through membrane channels. Prog. Biophys. Mol. Biol. 46: 51-96.
7. Hille, B. 1992. Ionic Channels of Excitable Membranes, 2nd Ed. Sinauer Associates, Sunderland, MA.
8. Hoyles, M., S. Kuyucak, and S. H. Chung. 1996. Energy barrier presented to ions by the vestibule of the biological membrane channel. Biophys. J. 70:1628-1642.
9. Jakobsson, E., and S.-W. Chiu. 1987. Stochastic theory of singly occupied ion channels. Biophys. J. 52:33-46.
10. Jordan, P. C. 1987. How pore mouth charge distributions alter the permeability of transmembrane ionic channels. Biophys. J. 51:297-311.
11. Jordan, P. C., R. J. Bacquet, J. A. McCammon, and P. Tran. 1989. How electrolyte shielding influences the electrical potential in transmembrane ion channels. Biophys. J. 55:1041-1052.
12. Kuyucak, S., and S. H. Chung. 1994. Temperature dependence of conductivity in electrolyte solutions and ionic channels of biological membranes. Biophys. Chem. 52:15-24.
13. Kuyucak, S., M. Hoyles, and S.-H. Chung. 1997. Analytical solutions of Poisson's equation for realistic geometrical shapes of membrane ion channels. Biophys. J. 74:000-000.
14. Mackay, D. H. J., P. H. Berens, K. R. Wilson, and A. T. Hagler. 1984. Structure and dynamics of ion transport through gramicidin A. Biophys. J. 46:229-248.
15. Milburn, T., D. A. Saint, and S. H. Chung. 1995. The conductance of the cardiac sodium channel: implications for mechanisms of ion permeation. Receptors Channels. 3:201-211.
16. Pauling, L. 1942. The Nature of the Chemical Bond. Cornell University Press, Ithaca, NY.
17. Reif, F. 1965. Fundamentals of Statistical and Thermal Physics. McGraw-Hill Kogakusha, Tokyo.
18. Roux, B., and M. Karplus. 1991. Ion transport in a model gramicidin channel: structure and thermodynamics. Biophys. J. 59:961-981.
19. Toyoshima, C., and N. Unwin. 1988. Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes. Nature. 336: 247-250.
20. van Gunsteren, W. F., and H. J. C. Berendsen. 1982. Algorithms for Brownian dynamics. Mol. Phys. 45:637-647.
21. van Gunsteren, W. F., H. J. C. Berendsen, and J. A. Rullmann. 1981. Stochastic dynamics for molecules with constraints: Brownian dynamics of n-alkanes. Mol. Phys. 44:69-95.