Hypoallergenic variants of the Parietaria judaica major allergen par j 1: A member of the non-specific lipid transfer protein plant family

International Archives of Allergy and Immunology

Volumn 126, Issue 1, 2001, Pages 32-40

  Bonura, Angela ^a   Amoroso, Saverio ^a   Locorotondo, Giovanni ^a   Di Felice, Gabriella ^b   Tinghino, Raffaella ^b   Geraci, Domenico ^a   Colombo, Paolo ^a,c  

^a Ospedale Civile Di Vicenza   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c CNR   (Italy)

Author keywords

Hypoallergenic recombinant Par j 1 mutants; Immunoglobulin E; Par j 1 recombinant allergen; Parietaria judaica; Peripheral blood mononuclear cell proliferation; Skin prick test

Indexed keywords

ALLERGEN; BRIDGED PEPTIDE; DISULFIDE; IMMUNOGLOBULIN E ANTIBODY; LIPID TRANSFER PROTEIN; MUTANT PROTEIN;

ALLERGENICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFORMATIONAL TRANSITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOBLOTTING; IMMUNOTHERAPY; MONONUCLEAR CELL; NUCLEOTIDE SEQUENCE; PARIETARIA JUDAICA; PLANT; PRICK TEST; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE;

ALLERGENS; ANIMALS; ANTIGENS, PLANT; BASE SEQUENCE; CARRIER PROTEINS; DESENSITIZATION, IMMUNOLOGIC; DISULFIDES; DNA, PLANT; GLYCOPROTEINS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; LYMPHOCYTE ACTIVATION; PLANT PROTEINS; RABBITS; T-LYMPHOCYTES; URTICACEAE; VARIATION (GENETICS);

EID: 0034774462     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000049492     Document Type: Article

References (43)

1. Induction and regulation of the IgE response
2. IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE
3. Serum-IgE-facilitated allergen presentation in atopic disease
4. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation
5. Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants
6. Allergen immunotherapy: Therapeutic vaccines for allergic diseases. A WHO position paper
7. Long-term clinical efficacy of grass-pollen immunotherapy
8. Bee venom immuno-therapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures
9. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals
10. Recombinant allergens for diagnosis and therapy of allergic disease
11. Pollen-related allergy in Europe
12. Parietariaas a cause of asthma
13. Purification and characterization of allergens fromParietaria officinalis pollen
14. Identification and characterization of Parietaria judaica allergens
15. Isolation and purification of a major allergen from Parietaria officinalis pollen
16. Purification of Parj I, a major allergen from Parietaria judaica pollen
17. cDNA cloning, expression and primary structure of Par jI, a major allergen of Parietaria judaica pollen
18. cDNA cloning, sequence analysis and allergological characterization of Par j 2.0101, a new major allergen of the Parietaria judaica pollen
19. An update on allergens. Parietaria pollen allergens
20. Isolation and characterization of two cDNA clones coding for isoforms of the Parietaria judaica major allergen Par j 1.0101
21. Solution structure of a lipid transfer protein extracted from rice seeds. Comparison with homologous proteins
22. Identification of an immunodominant IgE epitope of the Parietaria judaica major allergen
23. DNA sequencing with chain-terminating inhibitors
24. Interleu-kin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type
25. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations
26. Studies on 'allergoids' prepared from naturally occurring allergens. I. Assay of allergenicity and antigenicity of formalinized rye group I component
27. Anti-interferon gamma treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses
28. The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells
29. 'Allergen engineering': Variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity
30. B cell epitopes of the major timothy grass pollen allergen, Phl p 1, revealed by gene fragmentation as candidates for immunotherapy
31. Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: Contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2
32. Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy
33. Epitope mapping of the house-dust-mite allergen Der p 2 by means of site-directed mutagenesis
34. The IgE-binding epitopes of rPar j 2, a major allergen of Parietaria judaica pollen, are heterogeneously recognized among allergic subjects
35. Mechanisms of allergen-specific immunotherapy
36. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I
37. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
38. Heterogeneity in the polyclonal T cell response to birch pollen allergens
39. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
40. Lipid transfer protein: A pan-allergen in plant-derived foods that is highly resistant to pepsin digestion
41. Evidence for a lipid transfer protein as the major allergen of apricot
42. Complete amino acid sequence determination of the major allergen of peach (Prunus persica) Pru p 1
43. Lipid-transfer proteins are relevant allergens in fruit allergy