Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion

Journal of Biological Chemistry

Volumn 281, Issue 8, 2006, Pages 5042-5049

  Song, Gang ^a   Lazar, Greg A ^b   Kortemme, Tanja ^c,d   Shimaoka, Motomu ^a   Desjarlais, John R ^b   Baker, David ^c   Springer, Timothy A ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Xencor Inc   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CENTER FOR BLOOD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; AMINO ACIDS; ANTIGENS; CELLS; GENETIC ENGINEERING; MOLECULAR STRUCTURE; MONOMERS; REACTION KINETICS;

INFLAMMATORY REACTIONS; INTERCELLULAR ADHESION; LIGAND BINDING; RATIONAL DESIGN;

MOLECULAR BIOLOGY;

INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAGNESIUM ION; MUTANT PROTEIN; COMPLEMENTARY DNA; LIGAND; MAGNESIUM;

AMINO ACID SUBSTITUTION; ARTICLE; CELL ADHESION; HYDROPHOBICITY; LIGAND BINDING; PRIORITY JOURNAL; BIOLOGY; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE VECTOR; GENETIC ENGINEERING; GENETIC VARIABILITY; HUMAN; INFLAMMATION; KINETICS; METABOLISM; METHODOLOGY; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE;

CELL ADHESION; CELL LINE; COMPUTATIONAL BIOLOGY; DNA, COMPLEMENTARY; FLOW CYTOMETRY; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; INFLAMMATION; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; KINETICS; LIGANDS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MAGNESIUM; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; SOFTWARE; VARIATION (GENETICS);

EID: 33646173276     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510454200     Document Type: Article

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