A simple theoretical model explains Dynein's response to load

Biophysical Journal

Volumn 90, Issue 3, 2006, Pages 811-821

  Yi, Qin Gao ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DYNEIN ADENOSINE TRIPHOSPHATASE;

ARTICLE; CONFORMATIONAL TRANSITION; ENERGY; FORCE; HYDROLYSIS; MATHEMATICAL COMPUTING; MICROTUBULE; PREDICTION; PROTEIN CONFORMATION; THEORETICAL MODEL; VELOCITY;

EID: 33646171262     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.105.073189     Document Type: Article

References (36)

1. Mallik, R., and S. P. Gross. 2004. Molecular motors: Strategies to get along. Curr. Biol. 14:R971-R982.
2. Burgess, S. A., and P. J. Knight. 2004. Is the dynein motor a winch? Curr. Opin. Struct. Biol. 14:138-146.
3. Welte, M. A. 2004. Bidirectional transport along microtubules. Curr. Biol. 14:R525-R537.
4. Samso, M., and M. P. Koonce. 2004. 25 angstrom resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring. J. Mol. Biol. 340:1059-1072.
5. Oiwa, K., and H. Sakakibara. 2005. Recent progress in dynein structure and mechanism. Curr. Opin. Cell Biol. 17:98-103.
6. Cross, R. A. 2004. Molecular motors: Dynein's gearbox. Curr. Biol. 14:R355-R356.
7. Koonce, M. P., and M. Samso. 2004. Of rings and levers: the dynein motor comes of age. Trends Cell Biol. 14:612-619.
8. Burgess, S. A., M. L. Walker, H. Sakakibara, K. Oiwa, and P. J. Knight. 2004. The structure of dynein-c by negative stain electron microscopy J. Struct. Biol. 146:205-216.
9. Burgess, S. A., M. L. Walker, H. Sakakibara, P. J. Knight, and O. Kazuhiro. 2003. Dynein structure and power stroke. Nature. 421:715-718.
10. Kon, T., M. Nishiura, R. Ohkura, R. Ohkura, Y. Y. Toyoshima, and K. Sutoh. 2004. Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein. Biochemistry. 43:11266-11274.
11. Takahashi, Y., M. Edamatsu, and Y. Y. Toyoshima. 2004. Multiple ATP-hydrolyzing sites that potentially function in cytoplasmic dynein. Proc. Natl. Acad. Sci. USA. 101:12865-12869.
12. Kikushima, K., T. Yagi, and R. Kamiya. 2004. Slow ADP-dependent acceleration of microtubule translocation produced by an axonemal dynein. FEBS Lett. 563:119-122.
13. Yildiz, A., M. Tomishige, R. D. Vale, and P. R. Selvin. 2004. Kinesin walks hand-over-hand. Science. 303:676-678.
14. Yildiz, A., J. N. Forkey, S. A. McKinney, T. Ha, Y. E. Goldman, and P. R. Selvin. 2003. Myosin V walks hand-over-hand: Single fluorophore imaging with 1.5-nm localization. Science. 300:2061-2065.
15. Schnitzer, M. J., K. Visscher, and S. M. Block. 2000. Force production by single kinesin motors. Nat. Cell Biol. 2:718-723.
16. Visscher, K., M. J. Schnitzer, and S. M. Block. 1999. Single kinesin molecules studied with a molecular force clamp. Nature. 400:184-189.
17. Nishiyama, M., H. Higuchi, and T. Yanagida. 2002. Chemomechanical coupling of the forward and backward steps of single kinesin molecules. Nat. Cell Biol. 4:790-797.
18. Sakakiara, H., H. Kojima, Y. Sakai, E. Katayama, and K. Oiwa. 1999. Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor. Nature. 400:586-589.
19. Hirakawa, E., H. Higuchi, and Y. Y. Toyoshima. 2000. Processive movement of single 22S dynein molecules occurs only at low ATP concentrations. Proc. Natl. Acad. Sci. USA. 97:2533-2537.
20. Iyadurai, S. J., M. G. Li, S. P. Gilbert, and T. S. Hays. 1999. Evidence for cooperative interactions between the two motor domains of cytoplasmic dynein. Curr. Biol. 9:771-774.
21. Mallik, R., Carter, Lex, S. A., King, S., J. & Gross, S.P. 2004. Cytoplasmic dynein functions as a gear in response to load. Nature 427: 649-652.
22. Karplus, M., and Y. Q. Gao. 2004. Biomolecular motors: the F-1-ATPase paradigm. Curr. Opin. Struct. Biol. 14:250-259.
23. Mizuno, N., S. Toba, M. Edamatsu, J. Watai-Nishii, N. Hirokawa, Y. Y. Toyoshima, and M. Kikkawa. 2004. Dynein and kinesin share an overlapping microtubule-binding site. EMBO J. 23:2459-2467.
24. 1 motor of ATP synthase. Nature. 396:279-282.
25. Xing, J. H., H. Y. Wang, C. von Ballmoos, P. Dimroth, and G. Oster. 2004. Torque generation by the Fo motor of the sodium ATPase. Biophys. J. 87:2148-2163.
26. Astumian, R. D., and I. Derenyi. 1999. A chemically reversible Brownian motor: application to kinesin and ncd. Biophys. J. 77:993-1002.
27. Inaba, K. 1995. ATP-dependent conformational-changes of dynein - evidence for changes in the interaction of dynein heavychain with the intermediate chain-1. J. Biochem. (Tokyo). 117:903-907.
28. Shingyoji, C., H. Higuchi, M. Yoshimura, E. Katayama, and T. Yanagida. 1998. Dynein arms are oscillating force generators. Nature. 393:711-714.
29. Wang, Z. H., and M. P. Sheetz. 1999. One-dimensional diffusion on microtubules of particles coated with cytoplasmic dynein an immunoglobulins. Cell Struct. Funct. 24:373-383.
30. Levy, R. M., M. Karplus, and J. A. Mccammon. 1979. Diffusive Langevin dynamics of model alkanes. Chem. Phys. Lett. 65:4-11.
31. Toba, S., and Y. Y. Toyoshima. 2004. Dissociation of double-headed cytoplasmic dynein into single-headed species and its motile properties. Cell Motil. Cytoskeleton. 58:281-289.
32. Shiroguchi, K., and Y. Y. Toyoshima. 2001. Regulation of monomeric dynein activity by ATP and ADP concentrations. Cell Motil. Cytoskeleton. 49:189-199.
33. Kojima, H., M. Kikumoto, H. Sakakibara, and K. Oiwa. 2002. Mechanical properties of a single-headed processive motor, inner-arm dynein subspecies-c of Chlamydomonas studied at the single molecule level. J. Biol. Phys. 28:335-345.
34. Tinoco, I., and C. Bustamante. 2002. The effect of force on thermodynamics and kinetics of single molecule reactions. Biophys. Chem. 101:513-533.
35. Ligon, L. A., M. Tokito, J. M. Finklestein, F. E. Grossman, and E. L. F. Holzbaur. 2004. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. J. Biol. Chem. 279:19201-19208.
36. Mocz, G., M. K. Helms, D. M. Jameson, and I. R. Gibbons. 1998. Probing the nucleotide binding sites of axonemal dynein with the fluorescent nucleotide analogue 2′ (3′)-O-(-N-methylanthraniloyl)-adenosine 5′-triphosphate. Biochemistry. 37:9862-9869.