Dynein structure and power stroke

Nature

Volumn 421, Issue 6924, 2003, Pages 715-718

  Burgess, Stan A ^a   Walker, Matt L ^a   Sakakibara, Hitoshi ^b   Knight, Peter J ^a   Oiwa, Kazuhiro ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ELECTRON MICROSCOPY; ENZYMES; IMAGE PROCESSING;

MICROTUBULE MOTORS;

MOLECULAR STRUCTURE;

ADENOSINE DIPHOSPHATE; DYNEIN ADENOSINE TRIPHOSPHATASE; ISOPROTEIN; NUCLEOTIDE; VANADIC ACID;

BIOLOGY;

ARTICLE; CELL VACUOLE; CHLAMYDOMONAS REINHARDTII; ELECTRON MICROSCOPY; FLAGELLUM; FORCE; IMAGE PROCESSING; MICROTUBULE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPERMATOZOON TAIL;

ADENOSINE DIPHOSPHATE; ANIMALS; CHLAMYDOMONAS REINHARDTII; DYNEIN ATPASE; FLAGELLA; MICROSCOPY, ELECTRON; MOVEMENT; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VANADATES;

CHLAMYDOMONAS REINHARDTII;

EID: 0037434697     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01377     Document Type: Article

References (41)

1. Gibbons, I. R. Dynein family of motor proteins: present status and future questions. Cell Motil. Cytoskel. 32, 136-144 (1995).
2. Gibbons, I. R. & Rowe, A. Dynein: a protein with adenosine triphosphatase activity from cilia. Science 149, 424-426 (1965).
3. Vernon, G. G. & Woolley, D. M. The propagation of a zone of activation along groups of flagellar doublet microtubules. Exp. Cell Res. 220, 482-494 (1995).
4. Woolley, D. M. The molecular motors of cilia and flagella. Essays Biochem. 35, 103-115 (2000).
5. DiBella, L. M. & King, S. M. Dynein motors of the Chlamydomonas flagellum. Int. Rev. Cytol. 210, 227-268 (2001).
6. Karki, S. & Holzbaur, L. F. Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11, 45-53 (1999).
7. King, S. M. The dynein microtubule motor. Biochim. Biophys. Acta 1496, 60-75 (2000).
8. Koonce, M. P. & Samso, M. Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium. Mol. Biol. Cell 7, 935-948 (1996).
9. Goodenough, U. W. & Heuser, J. Structural comparison of purified dynein proteins with in situ dynein arms. J. Mol. Biol. 180, 1083-1118 (1984).
10. Goodenough, U. W. et al. High-pressure liquid chromatography fractionation of Chlamydomonas dynein extracts and characterization of inner-arm dynein subunits. J. Mol. Biol. 194, 481-494 (1987).
11. Goodenough, U. W. & Heuser, J. E. in Cell Movement: the Dynein ATPases Vol. 1 (eds, Warner, F. D., Satir, P. & Gibbons, I. R.) 121-140 (Alan Liss, New York, 1989).
12. King, S. M. AAA domains and organization of the dynein motor unit. J. Cell Sci. 113, 2521-2526 (2000).
13. Asai, D. J. & Koonce, M. P. The dynein heavy chain: structure, mechanics and evolution. Trends Cell Biol. 11, 196-202 (2001).
14. Gee, M. A., Heuser, J. E. & Vallee, R. B. An extended microtubule-binding structure within the dynein motor domain. Nature 390, 636-639 (1997).
15. Vallee, R. B. & Gee, M. A. Make room for dynein. Trends Cell Biol. 8, 490-494 (1998).
16. Koonce, M. P. & Tikhonenko, I. Functional elements within the dynein microtubule-binding domain. Mol. Biol. Cell 11, 523-529 (2000).
17. Samsó, M., Radermacher, M., Frank, J. & Koonce, M. P. Structural characterization of a dynein motor domain. J. Mol. Biol. 276, 927-937 (1998).
18. Gibbons, I. R., Gibbons, B. H., Mocz, G. & Asai, D. Multiple nucleotide-binding sites in the sequence of dynein β heavy chain. Nature 352, 640-643 (1991).
19. Ogawa, K. Four ATP-binding sites in the midregion of the β heavy chain of dynein. Nature 352, 643-645 (1991).
20. Neuwald, A. F., Aravind, L., Spouge, J. L. & Koonin, E. V. AAA +: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 9, 27-43 (1999).
21. Vale, R. D. AAA proteins: lords of the ring. J. Cell Biol. 150, F13-F19 (2000).
22. Mocz, G. & Gibbons, I. R. Phase partition analysis of nucleotide binding to axonemal dynein. Biochemistry 35, 9204-9211 (1996).
23. Gibbons, I. R. et al. Photosensitized cleavage of dynein heavy chains. J. Biol. Chem. 262, 2780-2786 (1987).
24. Yagi, T. ADP-dependent microtubule translocation by flagellar inner-arm dyneins. Cell Struct. Funct. 25, 263-267 (2000).
25. Shiroguchi, K. & Toyoshima, Y. Regulation of monomeric dynein activity by ATP and ADP concentrations. Cell Motil. Cytoskel. 49, 189-199 (2001).
26. Johnson, K. A. Pathway of the microtubule-dynein ATPase and the structure of dynein: a comparison with actomyosin. Annu. Rev. Biophys. Biophys. Chem. 14, 161-188 (1985).
27. Goodenough, U. W. & Heuser, J. E. Substructure of the outer dynein arm. J. Cell Biol. 95, 798-815 (1982).
28. Burgess, S. A. Rigor and relaxed outer dynein arms in replicas of cryofixed motile flagella. J. Mol. Biol. 250, 52-63 (1995).
29. Vale, R. D. & Milligan, R. A. The way things move: looking under the hood at molecular motor proteins. Science 288, 88-95 (2000).
30. Sakakibara, H., Kojima, H., Sakai, Y., Katayama, E. & Oiwa, K. Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor. Nature 400, 586-590 (1999).
31. Frank, J. Three-dimensional Electron Microscopy of Macromolecular Assemblies (Academic, New York, 1996).
32. Gee, M. A. & Vallee, R. B. The role of the dynein stalk in cytoplasmic and flagellar motility. Eur. Biophys. J. 27, 466-473 (1998).
33. Mocz, G. & Gibbons, I. R. Model of the motor component of dynein heavy chain based on homology to the AAA family of oligomeric ATPases. Structure 9, 93-103 (2001).
34. Fan, J. & Amos, L. A. Antibodies to cytoplasmic dynein heavy chain map the surface and inhibit motility. J. Mol. Biol. 307, 1317-1327 (2001).
35. Okuno, M. Inhibition and relaxation of sea urchin sperm flagella. J. Cell Biol. 85, 712-725 (1980).
36. Vale, R. D., Soll, D. R. & Gibbons, I. R. One-dimensional diffusion of microtubules bound to flagellar dynein. Cell 59, 915-925 (1989).
37. Omoto, C. K. & Johnson, K. Activation of the dynein adenosine triphosphatase by microtubules. Biochemistry 25, 419-427 (1986).
38. Gibbons, I. R. & Mocz, G. Photocatalytic cleavage of proteins with vanadate and other transition metal complexes. Methods Enzymol. 196, 428-442 (1991).
39. Walker, M. L. et al. Two-headed binding of a processive myosin to F-actin. Nature 405, 804-807 (2000).
40. Elliot, A., Offer, G. & Burridge, K. Electron microscopy of myosin molecules from muscle and nonmuscle sources. Proc. R. Soc. Lond. B 193, 45-53 (1976).
41. Burgess, S. A., Walker, M. L., White, H. D. & Trinick, J. Flexibility within myosin heads revealed by negative stain and single-particle analysis. J. Cell Biol. 139, 675-681 (1997).