Recent progress in dynein structure and mechanism

Current Opinion in Cell Biology

Volumn 17, Issue 1, 2005, Pages 98-103

  Oiwa, Kazuhiro ^a   Sakakibara, Hitoshi ^a  

^a National Institute of Information and Communications Technology   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DYNEIN ADENOSINE TRIPHOSPHATASE;

AMINO ACID SEQUENCE; CELL FUNCTION; HYDROLYSIS; MICROTUBULE; MOLECULAR MODEL; MOTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGY; CHLAMYDOMONAS; DYNEIN ATPASE; FLAGELLA; HYDROLYSIS; MICROTUBULES; MODELS, BIOLOGICAL; NORMAL DISTRIBUTION; PEPTIDES; PROTEIN CONFORMATION; TETRAHYMENA;

EID: 12344266732     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2004.12.006     Document Type: Review

References (62)

1. I.R. Gibbons, and A.J. Rowe Dynein: a protein with adenosine triphosphatase activity from cilia Science 149 1965 424 426
2. I.R. Gibbons Cilia and flagella of eukaryotes J Cell Biol 91 1981 107s 124s
3. L.M. Di Bella, and S.M. King Dynein motors of the Chlamydomonas flagellum Int Rev Cytol 210 2001 227 268
4. R. Kamiya Functional diversity of axonemal dyneins as studied in Chlamydomonas mutants Int Rev Cytol 219 2002 115 155
5. O. Kagami, and R. Kamiya Translocation and rotation of microtubules caused by multiple species of Chlamydomonas inner-arm dynein J Cell Sci 103 1992 653 664
6. R.D. Vale, and Y.Y. Toyoshima Rotation and translocation of microtubules in vitro induced by dynein from Tetrahymena cilia Cell 52 1988 459 469
7. C. Shingyoji, H. Higuchi, M. Yoshimura, E. Katayama, and T. Yanagida Dynein arms are oscillating force generators Nature 393 1998 711 714
8. R.B. Vallee, J.C. Williams, D. Varma, and L.E. Barnhart Dynein: An ancient motor protein involved in multiple modes of transport J Neurobiol 58 2004 189 200
9. N. Hirokawa Kinesin and dynein superfamily proteins and the mechanism of organelle transport Science 279 1998 519 526
10. R.D. Vale The molecular motor toolbox for intracellular transport Cell 112 2003 467 480
11. M.A. Gee, J.E. Heuser, and R.B. Vallee An extended microtubule-binding structure within the dynein motor domain Nature 390 1997 636 639
12. M.P. Koonce, and I. Tikhonenko Functional elements within the dynein microtubule-binding domain Mol Biol Cell 11 2000 523 529
13. M. Nishiura, T. Kon, K. Shiroguchi, R. Ohkura, T. Shima, Y.Y. Toyoshima, and K. Sutoh A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules J Biol Chem 279 2004 22799 22802 The authors establish a method to express and purify the recombinant dynein while maintaining full motor activity.
14. +: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes Genome Res 9 1999 27 43
15. + superfamily ATPases: common structure - diverse function Genes Cells 6 2001 575 597
16. M. Samso, M. Radermacher, J. Frank, and M.P. Koonce Structural characterization of a dynein motor domain J Mol Biol 276 1998 927 937
17. M. Samso, and M.P. Koonce 25-Å resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring J Mol Biol 340 2004 1059 1072 Using negative-stain electron microscopy, the authors provide 3D reconstructions of a cytoplasmic dynein motor domain at 25 Å resolution. Specific Fab tags were used to localize the microtubule-binding domain.
18. S.A. Burgess, M.L. Walker, H. Sakakibara, P.J. Knight, and K. Oiwa Dynein structure and power stroke Nature 421 2003 715 718 The authors provide detailed images of an axonemal dynein obtained with negative-stain electron microscopy followed by single-particle image processing. This give the first demonstration of a conformational change accompanying product release from single dynein molecules, and propose a structural mechanism for the power stroke.
19. ••]) of the axonemal dynein by electron microscopy followed by single-particle image processing, revealing details of dynein structure and flexibility.
20. I.R. Gibbons, B.H. Gibbons, G. Mocz, and D.J. Asai Multiple nucleotide-binding sites in the sequence of dynein β heavy chain Nature 352 1991 640 643
21. K. Ogawa Four ATP-binding sites in the midregion of the β heavy chain of dynein Nature 352 1991 643 645
22. M.P. Koonce, P.M. Grissom, and J.R. McIntosh Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein J Cell Biol 119 1992 1597 1604
23. A. Mikami, B.M. Paschal, M. Mazumdar, and R.B. Vallee Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C) Neuron 10 1993 787 796
24. G. Mocz, and I.R. Gibbons Phase partition analysis of nucleotide binding to axonemal dynein Biochemistry 35 1996 9204 9211
25. G. Mocz, M.K. Helms, D.M. Jameson, and I.R. Gibbons Probing the nucleotide binding sites of axonemal dynein with the fluorescent nucleotide analogue 2′(3′)-O-(-N-Methylanthraniloyl)- adenosine 5′-triphosphate Biochemistry 37 1998 9862 9869
26. I.R. Gibbons, A. Lee-Eiford, G. Mocz, C.A. Phillipson, W.J. Tang, and B.H. Gibbons Photosensitized cleavage of dynein heavy chains. Cleavage at the 'V1 site' by irradiation at 365 nm in the presence of ATP and vanadate J Biol Chem 262 1987 2780 2786
27. T. Kon, M. Nishiura, R. Ohkura, Y. Toyoshima, and K. Sutoh Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein Biochemistry 43 2004 11266 11274 By detailed biochemical analyses of expressed and purified P-loop mutants of the Dictyostelium dynein heavy chain, the authors show that four nucleotide-binding/hydrolysis sites have distinct functional roles in dynein motor activity.
28. A. Silvanovich, M.G. Li, M. Serr, S. Mische, and T.S. Hays The third P-loop domain in cytoplasmic dynein heavy chain is essential for dynein motor function and ATP-sensitive microtubule binding Mol Biol Cell 14 2003 1355 1365 The first mutational analysis of P-loop functions within the first and third AAA domains of the Drosophila cytoplasmic dynein heavy chain, revealing that mutations in the third P-loop disrupt the communication pathway between the hydrolytic site in first AAA and the microtubule-binding domain.
29. T. Yagi ADP-dependent microtubule translocation by flagellar inner-arm dyneins Cell Struct Funct 25 2000 263 267
30. K. Shiroguchi, and Y.Y. Toyoshima Regulation of monomeric dynein activity by ATP and ADP concentrations Cell Motil Cytoskeleton 49 2001 189 199
31. G. Mocz, and I.R. Gibbons Model for the motor component of dynein heavy chain based on homology to the AAA family of oligomeric ATPases Structure(Camb) 9 2001 93 103
32. Y. Takahashi, M. Edamatsu, and Y.Y. Toyoshima Multiple ATP-hydrolyzing sites that potentially function in cytoplasmic dynein Proc Natl Acad Sci USA 101 2004 12865 12869 A molecular dissection of the function of multiple ATP binding sites in cytoplasmic dynein. The authors examine ATPase activities of truncated dynein fragments and their mutants expressed in E coli and show that multiple ATP-binding sites have the ability to hydrolyse ATP.
33. R.B. Vallee, and M.A. Gee Make room for dynein Trends Cell Biol 8 1998 490 494
34. D.J. Asai, and M.P. Koonce The dynein heavy chain: structure, mechanics and evolution Trends Cell Biol 11 2001 196 202
35. N. Mizuno, S. Toba, M. Edamatsu, J.W. Nishii, N. Hirokawa, Y.Y. Toyoshima, and M. Kikkawa Dynein and kinesin share an overlapping microtubule-binding site EMBO J 23 2004 2459 2467 The biochemical and structural properties of a recombinant dynein stalk head protein are studied using cryoelectron microscopy and helical three-dimensional image reconstruction.
36. P. Burkhard, J. Stetefeld, and S.V. Strelkov Coiled coils: a highly versatile protein folding motif Trends Cell Biol 11 2001 82 88
37. B. Berger, D.B. Wilson, E. Wolf, T. Tonchev, M. Milla, and P.S. Kim Predicting coiled coils by use of pairwise residue correlations Proc Natl Acad Sci USA 92 1995 8259 8263
38. U.W. Goodenough, and J.E. Heuser Outer and inner dynein arms of cilia and flagella Cell 41 1985 341 342
39. U. Goodenough, and J. Heuser Structural comparison of purified dynein proteins with in situ dynein arms J Mol Biol 180 1984 1083 1118
40. J. Howard, and J.A. Spudich Is the lever arm of myosin a molecular elastic element? Proc Natl Acad Sci USA 93 1996 4462 4464
41. C.B. Lindemann, and A.J. Hunt Does axonemal dynein push, pull, or oscillate? Cell Motil Cytoskeleton 56 2003 237 244
42. E. Hirakawa, H. Higuchi, and Y.Y. Toyoshima Processive movement of single 22S dynein molecules occurs only at low ATP concentrations Proc Natl Acad Sci USA 97 2000 2533 2537
43. H. Sakakibara, H. Kojima, Y. Sakai, E. Katayama, and K. Oiwa Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor Nature 400 1999 586 590
44. R.D. Vale AAA proteins: lords of the ring J Cell Biol 150 2000 F13 F19
45. R. Mallik, B.C. Carter, S.A. Lex, S.J. King, and S.P. Gross Cytoplasmic dynein functions as a gear in response to load Nature 427 2004 649 652 Single-molecule nanometry of cytoplasmic dynein using an optical trap technique shows that its step size decreases with increasing load. The authors propose a model in which the stepping distance per ATP is changed by the load-induced binding of ATP at secondary sites in the dynein head.
46. Z. Wang, S. Khan, and M.P. Sheetz Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin Biophys J 69 1995 1011 1023
47. Y. Okada, and N. Hirokawa A processive single-headed motor: kinesin superfamily protein KIF1A Science 283 1999 1152 1157
48. Y. Okada, H. Higuchi, and N. Hirokawa Processivity of the single-headed kinesin KIF1A through biased binding to tubulin Nature 424 2003 574 577
49. M. Kikkawa, Y. Okada, and N. Hirokawa 15 Å resolution model of the monomeric kinesin motor, KIF1A Cell 100 2000 241 252
50. R.D. Vale, D.R. Soll, and I.R. Gibbons One-dimensional diffusion of microtubules bound to flagellar dynein Cell 59 1989 915 925
51. R.D. Vale Myosin V motor proteins: marching stepwise towards a mechanism J Cell Biol 163 2003 445 450
52. W.R. Schief, and J. Howard Conformational changes during kinesin motility Curr Opin Cell Biol 13 2001 19 28
53. Z. Okten, L.S. Churchman, R.S. Rock, and J.A. Spudich Myosin VI walks hand-over-hand along actin Nat Struct Mol Biol 11 2004 884 887
54. T.J. Purcell, C. Morris, J.A. Spudich, and H.L. Sweeney Role of the lever arm in the processive stepping of myosin V Proc Natl Acad Sci USA 99 2002 14159 14164
55. T. Sakamoto, F. Wang, S. Schmitz, Y. Xu, Q. Xu, J.E. Molloy, C. Veigel, and J.R. Sellers Neck length and processivity of myosin V J Biol Chem 278 2003 29201 29207
56. S. Kamimura, and R. Kamiya High-frequency nanometre-scale vibration in 'quiescent' flagellar axonemes Nature 340 1989 476 478
57. H.M. Sakakibara, Y. Kunioka, T. Yamada, and S. Kamimura Diameter oscillation of axonemes in sea-urchin sperm flagella Biophys J 86 2004 346 352
58. C.J. Brokaw Computer simulation of flagellar movement VIII: coordination of dynein by local curvature control can generate helical bending waves Cell Motil Cytoskeleton 53 2002 103 124
59. R.H. Dillon, and L.J. Fauci An integrative model of internal axoneme mechanics and external fluid dynamics in ciliary beating J Theor Biol 207 2000 415 430
60. C.B. Lindemann Structural-functional relationships of the dynein, spokes, and central-pair projections predicted from an analysis of the forces acting within a flagellum Biophys J 84 2003 4115 4126
61. S. Gueron, and K. Levit-Gurevich A three-dimensional model for ciliary motion based on the internal 9+2 structure Proc R Soc Lond B Biol Sci 268 2001 599 607
62. K.A. Johnson Pathway of the microtubule-dynein ATPase and the structure of dynein: a comparison with actomyosin Annu Rev Biophys Biophys Chem 14 1985 161 188