메뉴 건너뛰기




Volumn 4, Issue 1, 2006, Pages 39-46

Cancer pharmacogenetics: The move from pharmacokinetics to pharmacodynamics

Author keywords

Anemia; Chemotherapy; Microsatellite instability; Polymorphism; Tandem repeat in the enhancer region (TSER)

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; ANTIARRHYTHMIC AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; CAPECITABINE; CL 387785; DEBRISOQUINE; DIHYDROPYRIMIDINE DEHYDROGENASE; DNA; DRUG METABOLIZING ENZYME; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GLUCURONOSYLTRANSFERASE 1A1; IMATINIB; IRINOTECAN; ISONIAZID; MERCAPTOPURINE; PRIMAQUINE; PROTEIN TYROSINE KINASE INHIBITOR; SPARTEINE; SUXAMETHONIUM; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33646152560     PISSN: 15701603     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016006776055400     Document Type: Review
Times cited : (8)

References (67)
  • 3
    • 0018874242 scopus 로고
    • Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine
    • Bertilsson, L.; Dengler, H. J.; Eichelbaum, M. and Schulz, H. U. (1980) Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine. Eur. J. Clin. Pharmacol. 17, 153-155.
    • (1980) Eur. J. Clin. Pharmacol. , vol.17 , pp. 153-155
    • Bertilsson, L.1    Dengler, H.J.2    Eichelbaum, M.3    Schulz, H.U.4
  • 5
    • 0030883212 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of irinotecan
    • Chabot, G. G. (1997) Clinical pharmacokinetics of irinotecan. Clin. Pharmacokinet. 33, 245-259.
    • (1997) Clin. Pharmacokinet. , vol.33 , pp. 245-259
    • Chabot, G.G.1
  • 6
    • 10944232621 scopus 로고    scopus 로고
    • The current clinical value of genomic instability
    • Diaz, L. A., Jr. (2005) The current clinical value of genomic instability. Semin. Cancer Biol. 15, 67-71.
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 67-71
    • Diaz Jr., L.A.1
  • 9
    • 0018900001 scopus 로고
    • A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population
    • Evans, D. A.; Mahgoub, A.; Sloan, T. P.; Idle, J. R. and Smith, R. L. (1980) A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. J. Med. Genet. 17, 102-105.
    • (1980) J. Med. Genet. , vol.17 , pp. 102-105
    • Evans, D.A.1    Mahgoub, A.2    Sloan, T.P.3    Idle, J.R.4    Smith, R.L.5
  • 10
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans, W. E. and Mcleod, H. L. (2003) Pharmacogenomics - drug disposition, drug targets, and side effects. N. Engl. J. Med. 348, 538-549.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    Mcleod, H.L.2
  • 11
    • 2642570170 scopus 로고    scopus 로고
    • Moving towards individualized medicine with pharmacogenomics
    • Evans, W. E. and Relling, M. V. (2004) Moving towards individualized medicine with pharmacogenomics. Nature 429, 464-468.
    • (2004) Nature , vol.429 , pp. 464-468
    • Evans, W.E.1    Relling, M.V.2
  • 12
    • 0141731323 scopus 로고    scopus 로고
    • Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer
    • Fallik, D.; Borrini, F.; Boige, V.; Viguier, J.; Jacob, S.; Miquel, C.; Sabourin, J. C.; Ducreux, M. and Praz, F. (2003) Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer. Cancer Res. 63, 5738-5744.
    • (2003) Cancer Res. , vol.63 , pp. 5738-5744
    • Fallik, D.1    Borrini, F.2    Boige, V.3    Viguier, J.4    Jacob, S.5    Miquel, C.6    Sabourin, J.C.7    Ducreux, M.8    Praz, F.9
  • 14
    • 18144425093 scopus 로고    scopus 로고
    • HER1/EGFR-targeted agents: Predicting the future for patients with unpredictable outcomes to therapy
    • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16, 538-548.
    • (2005) Ann. Oncol. , vol.16 , pp. 538-548
    • Giaccone, G.1
  • 16
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre, M. E.; Mohammed, M.; Ellwood, K.; Hsu, N.; Paquette, R.; Rao, P. N. and Sawyers, C. L. (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Rao, P.N.6    Sawyers, C.L.7
  • 19
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
    • Horie, N.; Aiba, H.; Oguro, K.; Hojo, H. and Takeishi, K. (1995) Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct. Funct. 20, 191-197.
    • (1995) Cell Struct. Funct. , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3    Hojo, H.4    Takeishi, K.5
  • 20
    • 19944426858 scopus 로고    scopus 로고
    • High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan
    • Huang, S. F.; Liu, H. P.; Li, L. H.; Ku, Y. C.; Fu, Y. N.; Tsai, H. Y.; Chen, Y. T.; Lin, Y. F.; Chang, W. C.; Kuo, H. P.; Wu, Y. C.; Chen, Y. R. and Tsai, S. F. (2004) High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. Clin. Cancer Res. 10, 8195-8203.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8195-8203
    • Huang, S.F.1    Liu, H.P.2    Li, L.H.3    Ku, Y.C.4    Fu, Y.N.5    Tsai, H.Y.6    Chen, Y.T.7    Lin, Y.F.8    Chang, W.C.9    Kuo, H.P.10    Wu, Y.C.11    Chen, Y.R.12    Tsai, S.F.13
  • 21
    • 0035860142 scopus 로고    scopus 로고
    • A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
    • Iacopetta, B.; Grieu, F.; Joseph, D. and Elsaleh, H. (2001) A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br. J. Cancer 85, 827-830.
    • (2001) Br. J. Cancer , vol.85 , pp. 827-830
    • Iacopetta, B.1    Grieu, F.2    Joseph, D.3    Elsaleh, H.4
  • 24
    • 0036868961 scopus 로고    scopus 로고
    • Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity
    • Kawakami, K.; Ishida, Y.; Danenberg, K. D.; Omura, K.; Watanabe, G. and Danenberg, P. V. (2002) Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity. Jpn. J. Cancer Res. 93, 1221-1229.
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 1221-1229
    • Kawakami, K.1    Ishida, Y.2    Danenberg, K.D.3    Omura, K.4    Watanabe, G.5    Danenberg, P.V.6
  • 25
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • Kawakami, K.; Omura, K.; Kanehira, E. and Watanabe, Y. (1999) Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res. 19, 3249-3252.
    • (1999) Anticancer Res. , vol.19 , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 26
    • 0141507954 scopus 로고    scopus 로고
    • Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    • Kawakami, K. and Watanabe, G. (2003) Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res. 63, 6004-6007.
    • (2003) Cancer Res. , vol.63 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 28
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: Biological and clinical implications
    • Kosaka, T.; Yatabe, Y.; Endoh, H.; Kuwano, H.; Takahashi, T. and Mitsudomi, T. (2004) Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 64, 8919-8923.
    • (2004) Cancer Res. , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6
  • 31
    • 11144333540 scopus 로고    scopus 로고
    • Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer
    • Lee, J. W.; Soung, Y. H.; Kim, S. Y.; Park, W. S.; Nam, S. W.; Lee, J. Y.; Yoo, N. J. and Lee, S. H. (2005) Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer. Int. J. Cancer 113, 510-511.
    • (2005) Int. J. Cancer , vol.113 , pp. 510-511
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3    Park, W.S.4    Nam, S.W.5    Lee, J.Y.6    Yoo, N.J.7    Lee, S.H.8
  • 33
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola, M. V.; Stoehlmacher, J.; Muller-Weeks, S.; Cesarone, G.; Yu, M. C.; Lenz, H. J. and Ladner, R. D. (2003) A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res. 63, 2898-2904.
    • (2003) Cancer Res. , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.J.6    Ladner, R.D.7
  • 34
    • 2442480694 scopus 로고    scopus 로고
    • A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    • Mandola, M. V.; Stoehlmacher, J.; Zhang, W.; Groshen, S.; Yu, M. C.; Iqbal, S.; Lenz, H. J. and Ladner, R. D. (2004) A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 14, 319-327.
    • (2004) Pharmacogenetics , vol.14 , pp. 319-327
    • Mandola, M.V.1    Stoehlmacher, J.2    Zhang, W.3    Groshen, S.4    Yu, M.C.5    Iqbal, S.6    Lenz, H.J.7    Ladner, R.D.8
  • 35
    • 4344632633 scopus 로고    scopus 로고
    • UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer
    • Marcuello, E.; Altes, A.; Menoyo, A.; Del Rio, E.; Gomez-Pardo, M. and Baiget, M. (2004) UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer. Br. J. Cancer 91, 678-682.
    • (2004) Br. J. Cancer , vol.91 , pp. 678-682
    • Marcuello, E.1    Altes, A.2    Menoyo, A.3    Del Rio, E.4    Gomez-Pardo, M.5    Baiget, M.6
  • 38
    • 6344231838 scopus 로고    scopus 로고
    • Pharmacogenetics of irinotecan toxicity
    • Marsh, S. and Mcleod, H. L. (2004) Pharmacogenetics of irinotecan toxicity. Pharmacogenomics 5, 835-843.
    • (2004) Pharmacogenomics , vol.5 , pp. 835-843
    • Marsh, S.1    Mcleod, H.L.2
  • 39
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics - Five decades of therapeutic lessons from genetic diversity
    • Meyer, U. A. (2004) Pharmacogenetics - five decades of therapeutic lessons from genetic diversity. Nat. Rev. Genet. 5, 669-676.
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 669-676
    • Meyer, U.A.1
  • 40
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi, T.; Kosaka, T.; Endoh, H.; Horio, Y.; Hida, T.; Mori, S.; Hatooka, S.; Shinoda, M.; Takahashi, T. and Yatabe, Y. (2005) Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J. Clin. Oncol. 23, 2513-2520.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3    Horio, Y.4    Hida, T.5    Mori, S.6    Hatooka, S.7    Shinoda, M.8    Takahashi, T.9    Yatabe, Y.10
  • 45
    • 18244371651 scopus 로고    scopus 로고
    • Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain
    • Pao, W.; Miller, V. A.; Politi, K. A.; Riely, G. J.; Somwar, R.; Zakowski, M. F.; Kris, M. G. and Varmus, H. (2005) Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain. PLoS Med. 2, e73.
    • (2005) PLoS Med. , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 47
    • 12744255161 scopus 로고    scopus 로고
    • Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer
    • Perez-Soler, R. (2004) Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer. Clin. Lung Cancer 6(Suppl 1), S20-S23.
    • (2004) Clin. Lung Cancer , vol.6 , Issue.SUPPL. 1
    • Perez-Soler, R.1
  • 48
    • 4344604014 scopus 로고    scopus 로고
    • Pharmacogenomics in cancer therapy: Is host genome variability important?
    • Petros, W. P. and Evans, W. E. (2004) Pharmacogenomics in cancer therapy: is host genome variability important? Trends Pharmacol. Sci. 25, 457-464.
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 457-464
    • Petros, W.P.1    Evans, W.E.2
  • 49
    • 0038745780 scopus 로고    scopus 로고
    • An introduction to cost-effectiveness and cost-benefit analysis of pharmacogenomics
    • Phillips, K. A.; Veenstra, D.; Van Bebber, S. and Sakowski, J. (2003) An introduction to cost-effectiveness and cost-benefit analysis of pharmacogenomics. Pharmacogenomics 4, 231-239.
    • (2003) Pharmacogenomics , vol.4 , pp. 231-239
    • Phillips, K.A.1    Veenstra, D.2    Van Bebber, S.3    Sakowski, J.4
  • 50
    • 0035369825 scopus 로고    scopus 로고
    • Genetic susceptibility to adverse drug reactions
    • Pirmohamed, M. and Park, B. K. (2001) Genetic susceptibility to adverse drug reactions. Trends Pharmacol. Sci. 22, 298-305.
    • (2001) Trends Pharmacol. Sci. , vol.22 , pp. 298-305
    • Pirmohamed, M.1    Park, B.K.2
  • 53
    • 0022871780 scopus 로고
    • The metabolism of debrisoquine in man: (1) Regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis
    • Ritchie, J. C.; Crothers, M. J.; Shah, R. R.; Idle, J. R. and Smith, R. L. (1986) The metabolism of debrisoquine in man: (1) regioselectivity of hydroxylation and (2) aberrant oxidative metabolism in two sibling patients with carbimazole-induced agranulocytosis. Xenobiotica 16, 503-509.
    • (1986) Xenobiotica , vol.16 , pp. 503-509
    • Ritchie, J.C.1    Crothers, M.J.2    Shah, R.R.3    Idle, J.R.4    Smith, R.L.5
  • 54
    • 4143101374 scopus 로고    scopus 로고
    • Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: A molecular and clinical study of 75 patients
    • Rouits, E.; Boisdron-Celle, M.; Dumont, A.; Guerin, O.; Morel, A. and Gamelin, E. (2004) Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin. Cancer Res. 10, 5151-5159.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5151-5159
    • Rouits, E.1    Boisdron-Celle, M.2    Dumont, A.3    Guerin, O.4    Morel, A.5    Gamelin, E.6
  • 55
    • 0028364014 scopus 로고
    • Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase
    • Satoh, T.; Hosokawa, M.; Atsumi, R.; Suzuki, W.; Hakusui, H. and Nagai, E. (1994) Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase. Biol. Pharm. Bull. 17, 662-664.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 662-664
    • Satoh, T.1    Hosokawa, M.2    Atsumi, R.3    Suzuki, W.4    Hakusui, H.5    Nagai, E.6
  • 56
    • 22044454824 scopus 로고    scopus 로고
    • EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer
    • Shih, J. Y.; Gow, C. H. and Yang, P. C. (2005) EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer. N. Engl. J. Med. 353, 207-208.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 207-208
    • Shih, J.Y.1    Gow, C.H.2    Yang, P.C.3
  • 59
    • 3042728674 scopus 로고    scopus 로고
    • Pharmacogenetics - Expectations and reality
    • Tucker, G. (2004) Pharmacogenetics - expectations and reality. BMJ 329, 4-6.
    • (2004) BMJ , vol.329 , pp. 4-6
    • Tucker, G.1
  • 60
    • 0842268401 scopus 로고    scopus 로고
    • Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene
    • Uchida, K.; Hayashi, K.; Kawakami, K.; Schneider, S.; Yochim, J. M.; Kuramochi, H.; Takasaki, K.; Danenberg, K. D. and Danenberg, P. V. (2004) Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin. Cancer Res. 10, 433-439.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 433-439
    • Uchida, K.1    Hayashi, K.2    Kawakami, K.3    Schneider, S.4    Yochim, J.M.5    Kuramochi, H.6    Takasaki, K.7    Danenberg, K.D.8    Danenberg, P.V.9
  • 61
    • 0034518362 scopus 로고    scopus 로고
    • Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    • Ulrich, C. M.; Bigler, J.; Velicer, C. M.; Greene, E. A.; Farin, F. M. and Potter, J. D. (2000) Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol. Biomarkers Prev. 9, 1381-1385.
    • (2000) Cancer Epidemiol. Biomarkers Prev. , vol.9 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3    Greene, E.A.4    Farin, F.M.5    Potter, J.D.6
  • 62
    • 0032868050 scopus 로고    scopus 로고
    • Thymidylate synthase: A target for combination therapy and determinant of chemotherapeutic response in colorectal cancer
    • Van Triest, B. and Peters, G. J. (1999) Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. Oncology 57, 179-194.
    • (1999) Oncology , vol.57 , pp. 179-194
    • Van Triest, B.1    Peters, G.J.2
  • 66
    • 0023684586 scopus 로고
    • Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man
    • Zanger, U. M.; Vilbois, F.; Hardwick, J. P. and Meyer, U. A. (1988) Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man. Biochemistry 27, 5447-5454.
    • (1988) Biochemistry , vol.27 , pp. 5447-5454
    • Zanger, U.M.1    Vilbois, F.2    Hardwick, J.P.3    Meyer, U.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.