Effect of the umami peptides on the ligand binding and function of rat mGlu4a receptor might implicate this receptor in the monosodium glutamate taste transduction

British Journal of Pharmacology

Volumn 128, Issue 5, 1999, Pages 1027-1034

  Monastyrskaia, Katherine ^c   Lundstrom, Kenneth ^a   Plahl, Doris ^c   Acuna, Gonzalo ^b   Schweitzer, Christophe ^a   Malherbe, Pari ^a   Mutel, Vincent ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

35S GTP binding; 3h L AP4; Metabotropic glutamate receptor; Radioligand binding; Rat mGlu(4a) receptor; Taste transduction; Umami peptide

Indexed keywords

ASPARTIC ACID; GLUTAMATE SODIUM; GLUTAMIC ACID; GUANOSINE PHOSPHATE; INOSINE PHOSPHATE; LIGAND; METABOTROPIC RECEPTOR; PEPTIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CHO CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; TASTE;

ADULT; ANIMALS; BRAIN CHEMISTRY; FEMALE; FLAVORING AGENTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; HUMANS; KINETICS; LIGANDS; MALE; MEMBRANES; MIDDLE AGED; OLIGOPEPTIDES; PROPIONIC ACIDS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SODIUM GLUTAMATE; TASTE;

EID: 0032734779     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702885     Document Type: Article

References (36)

1. ARAMORI, I. & NAKANISHI, S. (1992). Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron, 8, 757-765.
2. BERGLUND, P., SJOBERG, M., GAROFF, H., ATKINS, G.J., SHEAHAN, B.J. & LILJESTRÖM, P. (1993). Semliki Forest virus expression system: production of conditionally infectious recombinant particles. Bio/Technology, 11, 916-920.
3. CHAUDHARI, N., YANG, H., LAMP, C., DELAY, E., CARTFORD, C., THAN, T. & ROPER S. (1996). The taste of monosodium glutamate: membrane receptors in taste buds. J. Neurosci., 16, 3817-3826.
4. CONN, P.J. & PIN, J.-P. (1997). Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol., 37, 205-237.
5. DOHERTY, A.J., PALMER, M.J., HENLEY, J.M., COLLINGRIDGE, G.L., & JANE, D.E. (1997). (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 36, 265-267.
6. 3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br. J. Pharmacol., 116, 3279-3287.
7. FAURION, A. (1991). Are umami taste receptor sites structurally related to glutamate CNS receptor sites? Physiol. Behav., 49, 905-912.
8. FEDOROV, A. & CHAUDHARI, N. (1997). Characterization of metabotropic glutamate receptor cDNA expressed in rat taste buds. Soc. Neurosci. abstr. 408. 13.
9. FLOR, P.J., LUKIC, S., RUEGG, D., LEONHARDT, T., KNOPFEL, T. & KUHN, R. (1995). Molecular cloning, functional expression and pharmacological characterisation of the human metabotropic glutamate receptor type 4. Neuropharmacalogy, 34, 149-155.
10. FREROT, E.M (1997). Firmenich patent, WO 97/04667.
11. αq,i proteins: characterization of new antagonists. Mol. Pharmacol., 50, 923-930.
12. HAN, G. & HAMPSON, D.R. (1999). Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J. Biol. Chem., 274, 10008-10013.
13. HOON, M.A., ADLER, E., LINDEMEIER, J., BATTEY, J.F., RYBA, N.J.P. & ZUKER, C.S. (1999). Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell, 96, 541-551.
14. HOON, M.A., NORTHUP, J-K., MARGOLSKEE, R.F. & RYBA, N.J.P. (1995). Functional expression of the taste specific G protein, α-gustducin. Biochem. J., 309, 629-636.
15. IKEDA, K. (1909). On a new seasoning. J. Tokyo Chem. Soc., 30, 820-836.
16. ITO, I., KOHDA, A., TANABE, S., HIROSE, E., HAYASHI, M., MITSUNAGA, S. & SUGIYAMA, H. (1992). 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport, 3, 1013-1016.
17. KINGSTON, A.E., ORNSTEIN, P.L., WRIGHT, R.A., JOHNSON, B.G., MAYNE, N.G., BURNETT, J.P., BELAGAJE, R., WU, S. & SCHOEPP, D.D. (1998). LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology, 37, 1-12.
18. 35SGTPγS binding assessment of metabotropic glutamate receptor standards in Chinese hamster ovary cell lines expressing the human metabotropic receptor subtypes 2 and 4. Neuropharmacology, 37, 179-187.
19. 35S binding assays. Soc. Neurosci Abstr. 229. 19.
20. KURAMITSU, R., TAKAHASHI, M., TAHARA, K., NAKAMURA, K. & OKAI, H. (1996). Tastes produced by peptides containing ionic groups and by related compounds. Biosci. Biotechnol. Biochem., 60, 1637-1642.
21. LINDEMANN, B. (1995). Sweet and salty: transduction in taste. News Physiol. Sci., 10, 166-170.
22. LUNDSTROM, K., MILLS, A., BUELL, G., ALLET, E., ADAMI, N. & LILJESTROM, P. (1994). High-level expression of the human neurokinin-1 receptor in mammalian cell lines using the Semliki Forest virus expression system. Eur. J. Biochem., 224, 917-921.
23. MCLAUGHLIN, S.K., MCKINNON, P.J. & MARGOLSKEE, R.F. (1992). Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature, 357, 563-569.
24. MING, D., RUIZ-AVILA, L. & MARGOLSKEE, R.F. (1998). Characterization and solubilisation of bitter-responsive receptors that couple to gustducin. Proc. Natl. Acad. Sci. U.S.A., 95, 8933-8938.
25. NAKATA, T., TAKAHASHI, M., NAKATANI, M., KURAMITSU, R., TAMURA, M. & OKAI, H. (1995). Role of basic and acidic fragments in delicious peptides (Lys-Gly-Glu-Glu-Ser-Leu-Ala) and the taste behaviour of sodium and potassium salts in acidic oligopeptides. Biosci. Biotechnol. Biochem., 59, 689-693.
26. RUIZ-AVILA, L., MCLAUGHLIN, S.K., WILDMAN, D., MCKINNON, P.J., ROBLCHON, A., SPICKOFSKY, N. & MARGOLSKEE, R.F. (1995). Coupling of bitter receptor to phosphodiestease through transducin in taste receptor cells. Nature, 376, 80-85.
27. SALT, T.E. & TURNER, J.P. (1998). Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonist S-2-methyl-4-carboxy-phenylglycine. Neuroscience, 85, 655-658.
28. SCHOEPP, D.D., JOHNSON, B.C., WRIGHT, R A., SALHOFF, C.R. MAYNE, N.G., WU, S., COCKERMAN, S.L., BURNETT, J.P., BELEGAJE, R., BLEAKMAN, D. & MONN, J.A. (1997). LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology, 36, 1-11.
29. TANABE, Y., MASU, M., ISHII, T., SHIGEMOTO, R. & NAKANISHI, S. (1992). A family of metabotropic glutamate receptors. Neuron, 8, 169-179.
30. TANABE, Y., NOMURA, A., MASU, N., SHIGEMOTO, R. & NAKANISHI, S. (1993). Signal transduction, pharmacological properties, and expression of two rat metabotropic glutamate receptors, mGluR3 and mGluR4a. J. Neurosci., 13, 1372-1378.
31. THOMSEN, C., PEKHLETSKI, R., HELDEMAN, B., GILBERT, T.A., O'HARA, P.O. & HAMPSON, D.R. (1997). Cloning and characterisation of a metabotropic glutamate receptor, mGluR4b. Neuropharmacology, 36, 21-30.
32. VAN DEN OORD, A.H.A. & VAN WASSENAAR, P.D. (1997). Umami peptides: assessment of this alleged taste properties. Z. Lebensm. Unters. Forsch. A., 205, 125-130.
33. WROBLEWSKA, B., WROBLEWSKI, J.T., PSHENICHKIN, S., SURIN, A., SULLIVAN, S.E. & NEALE, J.H. (1997). N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J. Neurochem., 69, 174-181.
34. WU, S., WRIGHT, R.A., ROCKEY, P.K., BURGETT, S.G., ARNOLD, J.S., ROSTECK, P.R., JOHNSON, B.G., SCHOEPP, D.D. & BELAGAJE, R.M. (1998). Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression and comparison of pharmacological properties in RGT cells. Mol. Brain Res., 53, 88-97.
35. YAMAGUCHI, S. (1991). Basic properties of umami and its effect on humans. Physiol Behav., 49, 833-841.
36. YAMAMOTO, T., MATSUO, R., FUJIMOTO, Y., FUKUNAGA, I., MIYASAKA, A. & IMOTO, T. (1991). Electrophysiological and behavioural studies on the taste of umami substances in the rat. Physiol Behav., 49, 919-925.