α1 Integrin Activation: A Link between β-Amyloid Deposition and Neuronal Death in Aging Hippocampal Neurons

Journal of Neuroscience Research

Volumn 75, Issue 5, 2004, Pages 688-697

  Anderson, Kelsi L ^a   Ferreira, Adriana ^a,b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Cell death; Fibrillar A ; Focal adhesion kinase; Integrins; Neurite degeneration

Indexed keywords

ALPHA1 INTEGRIN; AMYLOID BETA PROTEIN; BETA1 INTEGRIN; FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; TAU PROTEIN; ECHISTATIN; ENZYME INHIBITOR; PEPTIDE; VERY LATE ACTIVATION ANTIGEN 1;

AGING; ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; HIPPOCAMPUS; IN VITRO STUDY; MOLECULAR MECHANICS; NERVE CELL DEGENERATION; NEURITE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; METABOLISM; NERVE CELL; NEUROFILAMENT; PATHOLOGY; PHYSIOLOGY;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; CELL DEATH; ENZYME INHIBITORS; HIPPOCAMPUS; INTEGRIN ALPHA1; INTEGRIN ALPHA1BETA1; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROFIBRILS; NEURONS; PEPTIDES; RATS; SIGNAL TRANSDUCTION;

EID: 1442274909     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20018     Document Type: Article

References (54)

1. Akiyama H, Kawamata T, Dedhar S, McGeer PL. 1991. Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue. J Neuroimmunol 32:19-28.
2. Alvarez A, Toro R, Caceres A, Maccioni RB. 1999. Inhibition of tau phosphorylating protein kinase CDK5 prevents β-amyloid induced neuronal death. FEBS Lett 459:421-426.
3. Axmann A, Seidel D, Reimann T, Hempel U, Wenzel KW. 1998. Transforming growth factor-β1-induced activation of the Raf-MEK-MAPK signaling pathway in rat lung fibroblasts via a PKC-dependent mechanism. Biochem Biophys Res Commun 249:456-460.
4. Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE, 2003. A cell surface receptor complex for fibrillar b-amyloid mediates microglial activation. J Neurosci 23:2665-2674.
5. Bi X, Gall CM, Zhou J, Lynch G. 2002. Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists. Neuroscience 112:827-840.
6. Black L Berenbaum MC. 1964. Factors affecting the dye exclusion test for cell viability. Exp Cell Res 35:9-13.
7. Bottenstein JE, Sato G. 1979. Growth of a rat neuroblastoma cell line in serum-free supplemented media. Proc Natl Acad Sci USA 76:514-517.
8. Busciglio J, Lorenzo A, Yeh J, Yankner BA. 1995. β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14:879-888.
9. Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El Khoury JB. 2002. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta amyloid fibrils. Am J Pathol 160:101-112.
10. Cukierman E, Pankov R, Stevens DK, Yamada KM. 2001. Taking cell-matrix adhesions to the third dimension. Science 294:1708-1712.
11. Dabrowski A, Groblewski GE, Schafer C, Guan KL, Williams JA. 1997. Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. Am J Physiol 273:1472-1479.
12. Dineley KT, Westerman M, Bui D, Bell K, Ashe KH, Sweatt JD. 2001. β-amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's Disease. J Neurosci 21:4125-4133.
13. Eikelenboom P, Zhan SS, Kamphorst W, van der Valk P, Rozemuller JM. 1994. Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. Virchows Arch 424:421-427.
14. Ekinci FJ, Malik KU, Shea TB. 1999. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration. J Biol Chem 274:30322-30327.
15. Fabbri M, Castellani P, Gotwals PJ, Kotelianski V, Zardi L, Zocchi MR. 1996. A functional monoclonal antibody recognizing the human alpha 1-integrin I domain. Tissue Antigens 48:47-51.
16. Ferreira A, Busciglio J, Caceres A. 1989. Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP-2 and tau. Brain Res Dev Brain Res 49:215-228.
17. Ferreira A, Lu Q, Orecchio L, Kosik KS. 1997. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ. Mol Cell Neurosci 9:220-234.
18. Glenner GG, Wong CW. 1984. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885-890.
19. Goslin K, Banker GA. 1998. Rat hippocampal neurons in low-density culture. In: Banker GA, Goslin K, editors. Culturing nerve cells. Cambridge: MIT Press. p 339-370.
20. Grace EA, Busciglio J. 2003. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid b-induced neuronal dystrophy. J Neurosci 23:493-502.
21. Greenberg SM, Koo EH, Selkoe DJ, Qui WQ, Kosik KS. 1994. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci USA 91:7104-7108.
22. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. 1986. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089.
23. Haass C, Selkoe DJ. 1993. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75:1039-1042.
24. Imahori K, Uchida T. 1997. Physiology and pathology of tau protein kinases in relation to Alzheimer's disease. J Biochem 121:179-188.
25. Kosik KS, Joachim CL, Selkoe DJ. 1986. Microtubule-associated protein (tau) is a major antigenic component of paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 83:4044-4048.
26. Laemmli UK. 1970. Cleavage of structural protein during the assembly of the head of the bacteriophage T4. Nature 227:680-685.
27. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. 2000. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405:360-364.
28. Lorenzo A, Yankner BA. 1994. β-Amyloid neurotoxicity requires fibril formation and it is inhibited by Congo red. Proc Natl Acad Sci USA 91:12243-12247.
29. 1 integrin mediates elimination of amyloid-b peptide and protects against apoptosis. J Cell Biol 141:1019-1030.
30. Mendrick DL, Kelly DM, du Mont SS, Sandstrom DJ. 1995. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Lab Invest 72:367-375.
31. Mendrick DL, Kelly DM. 1993. Temporal expression of VLA-2 and modulation of its ligand specificity by rat glomerular epithelial cells in vitro. Lab Invest 69:690-702.
32. Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW. 2002. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem 277:47373-47379.
33. Morfini G, DiTella M, Feiguin F, Carri N, Caceres A. 1994. NT-3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons. J Neurosci Res 39:219-232.
34. Pinkstaff JK, Detterich J, Lynch G, Gall C. 1999. Integrin subunit gene expression is regionally differentiated in adult brain. J Neurosci 19:1541-1556.
35. Porras A, Alvarez AM, Valladares A, Benito M. 1998. p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-1/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes. Mol Endocrinol 12:825-834.
36. Porter JC, Hogg N. 1998. Integrins take partners: cross-talk between integrins and other membrane receptors. Trends Cell Biol 8:390-396.
37. Porton B, Ferreira A, De Lisi LE, Kao HT. 2004. A rare polymorphis affects a MAP kinase site in Synapsin III: possible relationship to schizophrenia biological psychiatry. (in press).
38. Rapoport M, Ferreira A. 2000. PD98059 prevents neurite degeneration induced by beta amyloid in mature hippocampal neurons. J Neurochem 74:125-133.
39. Rapoport M, Dawson HN, Binder LI, Vitek M.P, Ferreira A. 2002. Tau is essential to beta-amyloid-induced neurotoxicity. Proc Natl Acad Sci USA 99:6364-6369.
40. Sabo S, Lambert MP, Kessey K, Wade W, Krafft G, Klein WL. 1995. Interaction of beta-amyloid peptides with integrins in a human nerve cell line. Neurosci Lett 184:25-28.
41. Schlaepfer DD, Hunter T. 1996. Signal transduction from the extracellular matrix - a role for the focal adhesion protein-tyrosine kinase FAK. Cell Struct Funct 21:445-450.
42. Schaller MD, Parsons JT. 1994. Focal adhesion kinase and associated proteins. Curr Opin Cell Biol 6:705-710.
43. Selkoe DJ. 1994. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10:373-403.
44. Selkoe DJ. 2001. Alzheimer's disease genes, proteins, and therapy. Physiol Rev 81:741-766.
45. Shea TB, Deargay AN, Ekinci FJ. 1998. beta-Amyloid induced hyperphosphorylation of tau in human neuroblastoma cells involves MAP kinase. Neurosci Res Commun 22:45-49.
46. Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K. 1993. Tau protein kinase I is essential for amyloid β-protein induced neurotoxicity. Proc Natl Acad Sci USA 90:7789-7793.
47. Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
48. Van Gool D, Carmeliet G, Triau E, Cassiman JJ, Dom R. 1994. Appearance of localized immunoreactivity for the α4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls. Neurosci Lett 170:71-73.
49. Williamson R, Scales T, Clark BR, Gibb G, Reynolds CH, Kellie S, Bird IN, Varndell IM, Sheppard PW, Everall I, Anderton BH. 2002. Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases. J Neurosci 22:10-20.
50. Yamazaki T, Koo EH, Selkoe, DJ. 1997. Cell Surface amyloid β-protein precursor colocalizes with β1 integrins at substrate contact sites in neural cells. J Neurosci 17:1004-1010.
51. Yankner BA, Mesulam MM. 1991. Seminars in medicine of the Beth Israel Hospital, Boston. Beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med 325:1849-1857.
52. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, Stork PJ. 1998. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626.
53. Zhang C, Lambert MP, Bunch C, Barber K, Wade WS, Krafft GA, Klein W. 1994. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's Aβ peptide. J Biol Chem 41:25247-25250.
54. Zhu X, Assoian RK. 1995. Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 6:273-282.