The integrin family of cell adhesion molecules has multiple functions within the CNS

Journal of Neuroscience Research

Volumn 69, Issue 3, 2002, Pages 286-291

  Milner, Richard ^a   Campbell, Iain L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Endothelial cell; Extracellular matrix (ECM); Integrins; Microglia; Synaptic plasticity

Indexed keywords

INTEGRIN;

BLOOD BRAIN BARRIER; CELL ADHESION; CELL DEATH; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM FUNCTION; CYTOPLASM; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; LEUKOCYTE ACTIVATION; MICROGLIA; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; SHORT SURVEY; SYNAPTOGENESIS;

ANIMALS; CELL ADHESION MOLECULES, NEURON-GLIA; CENTRAL NERVOUS SYSTEM; HUMANS; INFLAMMATION; INTEGRINS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 0036682158     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10321     Document Type: Short Survey

References (44)

1. Brain microglia constitutively express beta-2 integrins
2. Distinct functions of alpha 3 and alpha v integrin receptors in neuronal migration and laminar organization of the cerebral cortex
3. The role of integrins in immune-mediated diseases of the nervous system
4. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
5. Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: Pharmacological studies and the characterization of a candidate matrix receptor
6. Making memories stick: Cell-adhesion molecules in synaptic plasticity
7. Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in mutiple sclerosis lesions
8. Fibronectin and laminin regulate the in vitro differentiation of microglial cells
9. Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse
10. Reelin binds alpha3beta1 integrin and inhibits neuronal migration
11. The role of αv integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
12. Retrovirally introduced antisense integrin RNA inhibits neuroblast migration in vivo
13. Essential role of alpha 6 integrins in cortical and retinal lamination
14. β1-class integrins regulate the development of laminae and folia in the cerebral cortex
15. Integrin-mediated short-term memory in Drosophila
16. Resting microglial cells in vitro: Analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures
17. Adhesion molecule expression on phagocytic microglial cells following anterograde degeneration of perforant path axons
18. Central nervous system neuronal migration
19. Integrins
20. Integrins: Versatility, modulation and signaling in cell adhesion
21. Targeted mutations in cell adhesion genes: What have we learned from them?
22. Integrins: Possible functions in the adult CNS
23. Integrin family of cell adhesion molecules in the injured brain: Regulation and cellular localization in the normal and regenerating mouse facial motor nucleus
24. Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture
25. Decrease in vascular integrin immunoreactivity and selective loss of capillaries during focal cerebral ischemia and reperfusion
26. Microglia: A sensor for pathological events in the CNS
27. Laminin is induced in astrocytes of adult brain by injury
28. Cytokines regulate microglial adhesion to laminin and astrocyte extracellular matrix via protein kinase C-dependent activation of the α6β1 integrin
29. Developmental regulation of β1 integrins during angiogenesis in the central nervous system
30. Merosin and congential muscular dystrophy
31. Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia
32. Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells
33. Integrin subunit gene expression is regionally differentiated in adult brain
34. Role of the Reelin signaling pathway in central nervous system development
35. Integrin-mediated regulation of synaptic morphology, transmission, and plasticity
36. The cell biology of the blood-brain barrier
37. Endothelial cell integrin laminin receptor expression in multiple sclerosis lesions
38. Adhesion receptors of the immune system
39. Time-dependent reversal of long-term potentiation by an integrin antagonist
40. Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury
41. Regulation of microglial expression of integrins by poly (ADP-ribose, polymerase-1
42. Phagocytic clearance of apoptotic neurons by microglia/brian macrophages in vitro: Involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition
43. IL-1-alpha and TNF-alpha differentially regulate CD4 and Mac-I expression in mouse microglia
44. Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain