Regulation of ion transport by the NHERF family of PDZ proteins

Physiology

Volumn 19, Issue 6, 2004, Pages 362-369

  Shenolikar, Shirish ^a   Voltz, James W ^a   Cunningham, Rochelle ^b   Weinman, Edward J ^b,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRIDGED COMPOUND; MEMBRANE PROTEIN; PDZ PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1;

BENIGN TUMOR; COVALENT BOND; CYSTIC FIBROSIS; HORMONAL REGULATION; ION TRANSPORT; NEUROFIBROMATOSIS; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW;

EID: 10444286035     PISSN: 15489213     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiol.00020.2004     Document Type: Review

References (68)

1. + exchanger isoform 3 in a renal polarized epithelial cell model. J Biol Chem 277: 21480-21488, 2002.
2. Bernardo AA, Kear FT, Santos AV, Ma J, Steplock D, Robey RB, and Weinman EJ. Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor. J Clin Invest 104: 195-201, 1999.
3. Breton S, Wiederhold T, Marshansky V, Nsumu NN, Ramesh V, and Brown D. The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells. J Biol Chem 275: 18219-18224, 2000.
4. Cao TT, Deacon HW, Reczek D, Bretscher A, and von Zastrow M. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor. Nature 401: 286-290, 1999.
5. Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, and Guggino WB. A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression. J Biol Chem 277: 3520-3529, 2002.
6. Custer M, Spindler B, Verrey F, Murer H, and Biber J. Identification of a new gene product (diphor-1) regulated by dietary phosphate. Am J Physiol Renal Physiol 273: F801-F806, 1997.
7. + exchanger regulatory factor 2 in apical plasma membranes. J Biol Chem 277: 10506-10511, 2002.
8. Fanning AS and Anderson JM. Protein modules as organizers of membrane structure. Curr Opin Cell Biol 11: 432-439, 1999.
9. Fouassier L, Yun CC, Fitz JG, and Doctor RB. Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions. J Biol Chem 275: 25039-25045, 2000.
10. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, and Murer H. PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int 64: 1733-1745, 2003.
11. i cotransporter with PDZ proteins. J Biol Chem 276: 9206-9213, 2001.
12. Glynne PA, Darling KE, Picot J, and Evans TJ. Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output. J Biol Chem 277: 33132-33138, 2002.
13. + exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci USA 95: 8496-8501, 1998.
14. + exchange. Nature 392: 626-630, 1998.
15. Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, and Lefkowitz RJ. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. J Biol Chem 274: 24328-24334, 1999.
16. + exchanger regulatory factor-1 by Cdc2 kinase. J Biol Chem 276: 41559-41565, 2001.
17. Hegedus T, Sessler T, Scott R, Thelin W, Bakos E, Varadi A, Szabo K, Homolya L, Milgram SL, and Sarkadi B. C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun 302: 454-461, 2003.
18. + exchanger regulatory factor 2. J Biol Chem 275: 16632-16637, 2000.
19. Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, and Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J 19: 6778-6791, 2000.
20. + exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 276: 19683-19686, 2001.
21. + exchanger regulatory factor interaction with the β2 adrenergic and platelet-derived growth factor receptors. J Biol Chem 277: 18973-18978, 2002.
22. + exchanger 3 (NHE3) requires an NHE3-E3KARP-α-actinin-4 complex for oligomerization and endocytosis. J Biol Chem 277: 23714-23724, 2002.
23. Kishi M, Liu X, Hirakawa T, Reczek D, Bretscher A, and Ascoli M. Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat Ih receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway. Mol Endocrinol 15: 1624-1635, 2001.
24. Kocher O, Pal R, Roberts M, Cirovic C, and Gilchrist A. Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol 23: 1175-1180, 2003.
25. + exchange. Biochemistry 41: 12336-12342, 2002.
26. Lamprecht G, Weinman EJ, and Yun CH. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem 273: 29972-29978, 1998.
27. Lau AG and Hall RA. Oligomerization of NHERF-1 and NHERF-2 PDZ domains: differential regulation by association with receptor carboxyl-termini and by phosphorylation. Biochemistry 40: 8572-8580, 2001.
28. Lederer ED, Khundmiri SJ, and Weinman EJ. Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol 14: 1711-1719, 2003.
29. + exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. J Biol Chem 278: 16494-16501, 2003.
30. + exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. J Biol Chem 277: 27545-27552, 2002.
31. + exchange regulatory factor-2. Am J Physiol Renal Physiol 282: F1129-F1139, 2002.
32. + exchange regulatory factor. J Biol Chem 277: 22925-22933, 2002.
33. + exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endocrinol 17: 2355-2364, 2003.
34. + exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 417: 858-861, 2002.
35. + exchanger regulatory factor potentiates receptor activity. Mol Cell Biol 20: 8352-8363, 2000.
36. Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, and Milgram SL. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J Cell Biol 147: 879-890, 1999.
37. Moyer BD, Denton J, Karlson KH, Reynolds D, Wang S, Mickle JE, Milewski M, Cutting GR, Guggino WB, Li M, and Stanton BA. A PDZ-interacting domain in CFTR is an apical membrane polarization signal. J Clin Invest 104: 1353-1361, 1999.
38. Nawrot M, West K, Huang J, Possin DE, Bretscher A, Crabb JW, and Saari JC. Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium. Invest Ophthalmol Vis Sci 45: 393-401, 2004.
39. Nourry C, Grant SG, and Borg JP. PDZ domain proteins: plug and play! Sci STKE 2003: RE7, 2003.
40. Ogura T, Furukawa T, Toyozaki T, Yamada K, Zheng YJ, Katayama Y, Nakaya H, and Inagaki N. CIC-3B, a novel CIC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC. FASEB J 16: 863-865, 2002.
41. Poulat F, Barbara PS, Desclozeaux M, Souiller S, Moniot B, Bonneaud N, Boizet B, and Berta P. The human testis determining factor SRY binds a nuclear factor containing PDZ protein interaction domains. J Biol Chem 272: 7167-7172, 1997.
42. +-ATPase subunit are PDZ motifs involved in their interaction. Am J Physiol Cell Physiol 284: C667-C673, 2003.
43. Raghuram V, Hormuth H, and Foskett JK. A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions. Proc Natl Acad Sci USA 100: 9620-9625, 2003.
44. Raghuram V, Mak DD, and Foskett JK. Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. Proc Natl Acad Sci USA 98: 1300-1305, 2001.
45. Reczek D, Berryman M, and Bretscher A. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J Cell Biol 139: 169-179, 1997.
46. Reczek D and Bretscher A. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol 153: 191-206, 2001.
47. Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, and Parent JL. Regulation of GTP-binding protein αq (Gαq) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50). J Biol Chem 277: 40751-40759, 2002.
48. Shenolikar S, Minkoff CM, Steplock DA, Evangelista C, Liu M, and Weinman EJ. N-terminal PDZ domain is required for NHERF dimerization. FEBS Lett 489: 233-236, 2001.
49. Shenolikar S, Voltz JW, Minkoff CM, Wade JB, and Weinman EJ. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci USA 99: 11470-11475, 2002.
50. Shibata T, Chuma M, Kokubu A, Sakamoto M, and Hirohashi S. EBP50, a β-catenin-associating protein, enhances Wnt signaling and is overexpressed in hepatocellular carcinoma. Hepatology 38: 178-186, 2003.
51. Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, Boucher RC, Stutts MJ, and Milgram SL. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 273: 19797-19801, 1998.
52. Sitaraman SV, Wang L, Wong M, Bruewer M, Hobert M, Yun CH, Merlin D, and Madara JL. The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J Biol Chem 277: 33188-33195, 2002.
53. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, and Cantley LC. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275: 73-77, 1997.
54. Stokowski RP and Cox DR. Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations. Am J Hum Genet 66: 873-891, 2000.
55. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, and Zhu MX. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 275: 37559-37564, 2000.
56. Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Citterich MH, Cesareni G, and Dente L. Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster. J Biol Chem 276: 42122-42130, 2001.
57. Van Ham M and Hendriks W. PDZ domains-glue and guide. Mol Biol Rep 30: 69-82, 2003.
58. Wade JB, Liu J, Coleman RA, Cunningham R, Steplock DA, Lee-Kwon W, Pallone TL, Shenolikar S, and Weinman EJ. Localization and interaction of NHERF isoforrns in the renal proximal tubule of the mouse. Am J Physiol Cell Physiol 285: C1494-C1503, 2003.
59. Wang S, Raab RW, Schatz PJ, Guggino WB, and Li M. Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett 427: 103-108, 1998.
60. Weinman EJ, Minkoff C, and Shenolikar S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol 279: F393-F399, 2000.
61. + exchanger requires a dissociable phosphoprotein cofactor. J Clin Invest 92: 1781-1786, 1993.
62. Weinman EJ, Steplock D, and Shenolikar S. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett 536: 141-144, 2003.
63. Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, and Shenolikar S. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). J Clin Invest 101: 2199-2206, 1998.
64. Weinman EJ, Wang Y, Wang F, Greer C, Steplock D, and Shenolikar S. A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. Biochemistry 42: 12662-12668, 2003.
65. Yoo D, Flagg TP, Olsen O, Raghuram V, Foskett JK, and Welling PA. Assembly and trafficking of a multiprotein ROMK (Kir1.1) channel complex by PDZ interactions. J Biol Chem 279: 6863-6873, 2003.
66. + exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1. J Am Soc Nephrol 13: 2823-2830, 2002.
67. + exchanger NHE3 and the cytoskeletal protein ezrin. J Biol Chem 273: 25856-25863, 1998.
68. + exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci USA 94: 3010-3015, 1997.