Human carboxylesterase 1: From drug metabolism to drug discovery

Biochemical Society Transactions

Volumn 31, Issue 3, 2003, Pages 620-624

  Redinbo, M R ^a,b,e   Bencharit, S ^a,c   Potter, P M ^a,d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e University of North Carolina at Chapel Hill   (United States)

Author keywords

Cholesterol metabolism; Cocaine; Heroin; Human carboxylesterase 1 inhibitor; X ray crystallography

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; BENZOYLECGONINE; CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 1 INHIBITOR; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTERASE; COCAINE; DIAMORPHINE; ENZYME INHIBITOR; HOMOCOCAINE; IRINOTECAN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MORPHINE; MORPHINE 6 ACETATE; NALOXONE; PALMITOYL COENZYME A HYDROLASE; SARIN; SOMAN; UNCLASSIFIED DRUG;

CATALYSIS; CHOLESTEROL METABOLISM; CONFERENCE PAPER; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL;

CARBOXYLIC ESTER HYDROLASES; COCAINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HEROIN; HUMANS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 0037526833     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0310620     Document Type: Conference Paper

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