Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy

Clinical Cancer Research

Volumn 5, Issue 4, 1999, Pages 917-924

  Danks, Mary K ^a   Morton, Christopher L ^a   Krull, Erik J ^a   Cheshire, Pamela J ^a   Richmond, Lois B ^a   Naeve, Clayton W ^a   Pawlik, Cynthia A ^a   Houghton, Peter J ^a   Potter, Philip M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CARBOXYLESTERASE; IRINOTECAN; PRODRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TARGETING; RABBIT; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOTRANSFORMATION; CAMPTOTHECIN; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NITROBENZENES; PHENYLACETATES; PRODRUGS; RABBITS; TUMOR CELLS, CULTURED;

EID: 0032929154     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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