Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin

Journal of Biological Chemistry

Volumn 272, Issue 23, 1997, Pages 14769-14775

  Pindel, Evgenia V ^a   Kedishvili, Natalia Y ^a   Abraham, Trent L ^a   Brzezinski, Monica R ^a   Zhang, Jing ^a   Dean, Robert A ^a,b   Bosron, William F ^a  

^a INDIANA UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; COCAINE; COMPLEMENTARY DNA; DIAMORPHINE; HYMECROMONE; LIVER ENZYME; MORPHINE 6 ACETATE;

AMINO ACID SEQUENCE; ARTICLE; DRUG HYDROLYSIS; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; CHROMATOGRAPHY, DEAE-CELLULOSE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CLONING, MOLECULAR; COCAINE; CRICETINAE; DNA PRIMERS; DNA, COMPLEMENTARY; HEROIN; HUMANS; HYDROLYSIS; KINETICS; LIVER; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; RABBITS; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

CRICETINAE; ORYCTOLAGUS CUNICULUS;

EID: 0030965160     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.23.14769     Document Type: Article

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