Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility

Chemical Research in Toxicology

Volumn 14, Issue 12, 2001, Pages 1563-1572

  Wheelock, C E ^a   Severson, T F ^a   Hammock, B D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,1 TRIFLUORO 3 (DECANE 1 SULFONYL)PROPAN 2,2 DIOL; 1,1,1 TRIFLUORO 3 (OCTANE 1 SULFONYL)PROPAN 2,2 DIOL; 1,1,1 TRIFLUORO 3 OCTYLSULFANYLPROPAN 2 ONE; ALIPHATIC COMPOUND; CARBOXYLESTERASE; CARBOXYLESTERASE INHIBITOR; ESTERASE INHIBITOR; IRINOTECAN; KETONE; ORGANOPHOSPHATE INSECTICIDE; SULFIDE; SULFONE DERIVATIVE; TRIFLUOROMETHYLKETONE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL TISSUE; ARTICLE; CATALYSIS; DETOXIFICATION; DRUG POTENCY; DRUG SOLUBILITY; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; EQUILIBRIUM CONSTANT; EVALUATION; HEMOLYMPH; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; ENZYME INHIBITORS; HYDROCARBONS, FLUORINATED; MICROSOMES, LIVER; RATS; SOLUBILITY; SWINE; WATER;

ANIMALIA; BRASSICA OLERACEA VAR. CAPITATA; SUIDAE; TRICHOPLUSIA NI;

EID: 0035659708     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx015508+     Document Type: Article

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